Gene signatures

Signatures (18) and Custom Report Builder
Title Organism Platform
1 NPC_3,4 DIHDROXYPHENYLACETIC ACID
2 NPC_CYANIDIN-3-O-GLUCOSIDE
3 NPC_HIPPURIC ACID
4 NPC_HOMOVANILLIC ACID
5 NPC_ISOBUTYRIC ACID
6 NPC_ISOVALERIC ACID
7 NPC_L-(+)TARTARIC ACID
8 NPC_MALVIDIN-3-O-GLUCOSIDE
9 NPC_P-DIHYDROCOUMARIC ACID
10 NPC_PYROGALLOL
11 NPC_QUERCETIN-3-O-GLUCORONIDE
12 NPC_RESVERATROL-3-O GLUCURONIDE
13 NPC_RESVERATROL
14 NPC_SODIUM PROPIONATE
15 NPC_VALERIC ACID
16 NPC_VANILLIC ACID
17 NPC_Z154373220
18 NPC_Z221560030

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.