Gene signatures

Signatures (59) and Custom Report Builder
Title Organism Platform
1 89508b7ab7
2 30a472dbb6
3 dc1da762a0
4 54aeb6e720
5 8bc82f6956
6 695dc487dd
7 bab95d287b
8 34b5e727f6
9 418cd6361c
10 b19713e269
11 893fa29e3f
12 f863ca6878
13 c352583cb8
14 9f62353840
15 47553ffe98
16 74d48cf8c0
17 27c5fc2a22
18 d513a0f92b
19 94344a7399
20 49852d4608
21 dbd142e887
22 cc634f5d09
23 fa5aad3375
24 66671a31de
25 13b0e2b964
26 0fa1cda885
27 1b82214289
28 25a7dce2f3
29 92e266e8e3
30 e44968cbc5
31 6da0ddaa09
32 21b9571d41
33 258ce48d74
34 ce5188b295
35 1d47ada373
36 3e76d1517a
37 b87d49c361
38 4e6705c5ea
39 a5875f1776
40 6e495d09b5
41 0bd8e9b47d
42 4a1c1ace56
43 7959cbd656
44 a6cd0e90b2
45 b61ef0cb5f
46 98e4bcb28d
47 4482cae789
48 66b5c093de
49 8a83eb7f51
50 2a5ab29358
51 a36a09b459
52 46690951b8
53 9632a65ab4
54 fe72237b2e
55 30a28e73b6
56 ccb7e77786
57 b7b6ecbc48
58 38ab18c265
59 82bffd8219

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.