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Gene signatures

Signatures (24) and Custom Report Builder
Title Organism Platform
1 Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior Mus musculus Mus musculus
2 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
3 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
4 Thiazolidinedione pioglitazone effect on Fischer 344 model of aging: hippocampus Rattus norvegicus Rattus norvegicus
5 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
6 Fisher 344 rat model of aging: parietal cortex Rattus norvegicus Rattus norvegicus
7 Cardiac aging Rattus norvegicus Rattus norvegicus
8 Vitamin E supplementation effect on aged heart Mus musculus Mus musculus
9 Vitamin E supplementation effect on aged brain Mus musculus Mus musculus
10 Age-related aortic vasculopathy model Rattus norvegicus Rattus norvegicus
11 Hippocampal aging and cognitive impairment Rattus norvegicus Rattus norvegicus
12 Age-related aortic vasculopathy model Rattus norvegicus Rattus norvegicus
13 Hippocampal aging and cognitive impairment Rattus norvegicus Rattus norvegicus
14 Age-related aortic vasculopathy model Rattus norvegicus Rattus norvegicus
15 Desmin deficiency effect on young and adult skeletal muscles Mus musculus Mus musculus
16 Skeletal muscles from men and women of various ages Homo sapiens Homo sapiens
17 Skeletal muscles from men and women of various ages Homo sapiens Homo sapiens
18 Skeletal muscles from men and women of various ages Homo sapiens Homo sapiens
19 Young and aged skeletal muscles response to long-term vigorous endurance exercise Homo sapiens Homo sapiens
20 Model of cerebral aging and Alzheimer's disease: temporal cortex Homo sapiens; Microcebus murinus Homo sapiens; Microcebus murinus
21 Model of cerebral aging and Alzheimer's disease: temporal cortex Homo sapiens; Microcebus murinus Homo sapiens; Microcebus murinus
22 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
23 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
24 Caloric restriction effect on aged skeletal muscle Mus musculus Mus musculus

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.