Liver, custom report for AG

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Gene signatures

Signatures (16) and Custom Report Builder
Title Organism Platform
1 Mdr2 knockout model of hepatocellular carcinoma at precancerous stages Mus musculus Mus musculus
2 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
3 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
4 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
5 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
6 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
7 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
8 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
9 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
10 Hepatic gene expression changes in aging and R-α-lipoic acid supplementation: Necroinflammatory phenotype, lipid synthesis regulation and circadian rhythms. Rattus norvegicus Rattus norvegicus
11 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
12 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
13 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
14 Age effect on livers of long-lived Snell dwarf mutants Mus musculus Mus musculus
15 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
16 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.