only_human, custom report for AG

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Gene signatures

Signatures (29) and Custom Report Builder
Title Organism Platform
1 Gene Expression Data in Human Monocyte-derived Dendritic Cell (MoDC) from Young and Aged Donors Homo sapiens Homo sapiens
2 Aging of Human Fibroblast Homo sapiens Homo sapiens
3 Aging of Human Fibroblast Homo sapiens Homo sapiens
4 Muscle function and aging - female (HG-U133B) Homo sapiens Homo sapiens
5 Muscle function and aging - male (HG-U133B) Homo sapiens Homo sapiens
6 Expression data from young and old healthy humans, as well as HGPS patients Homo sapiens Homo sapiens
7 Moderate stage Huntington's disease lymphocytes Homo sapiens Homo sapiens
8 Muscle function and aging - female (HG-U133B) Homo sapiens Homo sapiens
9 The effects of aging on circadian patterns of gene expression in the human prefrontal cortex Homo sapiens Homo sapiens
10 The effects of aging on circadian patterns of gene expression in the human prefrontal cortex Homo sapiens Homo sapiens
11 Effects of Aging and Anatomic Location on Gene Expression in Human Retina Homo sapiens Homo sapiens
12 Aging-induced differential methylation in human PBMCs occurs with but often without change in expression of the associated gene (Expression) Homo sapiens Homo sapiens
13 REST and Stress Resistance in Aging and Alzheimer’s Disease Homo sapiens Homo sapiens
14 Transcriptome Analysis of Human Injured Meniscus Reveals a Distinct Phenotype of Meniscus Degeneration with Aging Homo sapiens Homo sapiens
15 The impact of aging on memory T cell phenotype and function in the human bone marrow Homo sapiens Homo sapiens
16 Resistance Exercise Reverses Aging in Human Skeletal Muscle Homo sapiens Homo sapiens
17 Transcriptional profile of aging human muscle Homo sapiens Homo sapiens
18 Aging effect on bone marrow hematopoietic stem cells Homo sapiens Homo sapiens
19 Williams-Beuren Syndrome: fibroblast cell lines Homo sapiens Homo sapiens
20 Age effect on normal adult brain: frontal cortical region Homo sapiens Homo sapiens
21 Age effect on normal adult brain: frontal cortical region Homo sapiens Homo sapiens
22 Schizophrenia: postmortem anterior prefrontal cortex Homo sapiens Homo sapiens
23 Schizophrenia: postmortem superior temporal cortex Homo sapiens Homo sapiens
24 Skeletal muscles from men and women of various ages Homo sapiens Homo sapiens
25 Skeletal muscles from men and women of various ages Homo sapiens Homo sapiens
26 Young and aged skeletal muscles response to long-term vigorous endurance exercise Homo sapiens Homo sapiens
27 Model of cerebral aging and Alzheimer's disease: temporal cortex Homo sapiens; Microcebus murinus Homo sapiens; Microcebus murinus
28 Model of cerebral aging and Alzheimer's disease: temporal cortex Homo sapiens; Microcebus murinus Homo sapiens; Microcebus murinus
29 Transcriptome analysis of aging muscle progenitors (human myoblasts) Homo sapiens Homo sapiens

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.