Gene signatures

Signatures (84) and Custom Report Builder
Title Organism Platform
1 pineal_day
2 Lymphoma_burkitts(Daudi)
3 Heart
4 Liver
5 Thyroid
6 Prostate
7 Pituitary
8 PancreaticIslet
9 721_B_lymphoblasts
10 CD34+
11 BDCA4+_DentriticCells
12 pineal_night
13 CD56+_NKCells
14 CD19+_BCells(neg._sel.)
15 CD4+_Tcells
16 CD8+_Tcells
17 CD14+_Monocytes
18 CD33+_Myeloid
19 WholeBlood
20 Adipocyte
21 SmoothMuscle
22 BronchialEpithelialCells
23 PrefrontalCortex
24 colon
25 small_intestine
26 Lung
27 Placenta
28 Colorectaladenocarcinoma
29 Leukemia_chronicMyelogenousK-562
30 Leukemia_promyelocytic-HL-60
31 CD105+_Endothelial
32 CD71+_EarlyErythroid
33 Wholebrain
34 retina
35 Caudatenucleus
36 MedullaOblongata
37 OccipitalLobe
38 GlobusPallidus
39 Cerebellum
40 CingulateCortex
41 ParietalLobe
42 Thalamus
43 SubthalamicNucleus
44 TemporalLobe
45 Amygdala
46 Pons
47 CerebellumPeduncles
48 Fetalbrain
49 Adrenalgland
50 Kidney
51 Ovary
52 Salivarygland
53 Pancreas
54 Trachea
55 AtrioventricularNode
56 Hypothalamus
57 CiliaryGanglion
58 DorsalRootGanglion
59 Skin
60 Fetalliver
61 Fetallung
62 Uterus
63 OlfactoryBulb
64 Lymphnode
65 Thymus
66 Leukemialymphoblastic(MOLT-4)
67 Spinalcord
68 Testis
69 TestisGermCell
70 TestisIntersitial
71 TestisSeminiferousTubule
72 TestisLeydigCell
73 AdrenalCortex
74 Appendix
75 SuperiorCervicalGanglion
76 TrigeminalGanglion
77 SkeletalMuscle
78 CardiacMyocytes
79 Tongue
80 UterusCorpus
81 Bonemarrow
82 Tonsil
83 FetalThyroid
84 Lymphoma_burkitts(Raji)

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.