Gene signatures

Signatures (49) and Custom Report Builder
Title Organism Platform
1 3-Hydroxy-DL-Kynurenine-5641-1
2 trifluoperazine-2684
3 trifluoperazine-1165
4 thioridazine-2690
5 thioridazine-1986
6 terfenadine-1381
7 sulpiride-4389
8 roxarsone-5051
9 quercetin-2499
10 prochlorperazine-2675
11 practolol-1587
12 PNU-0251126-3692
13 phthalylsulfathiazole-3371
14 phenindione-7289"
15 perhexiline-2410
16 nystatin-2500
17 lasalocid-3021
18 norcyclobenzaprine-2830
19 nifuroxazide-4253
20 niclosamide-1998
21 Nalidixic Acid-2297
22 Nafcillin-3983
23 myricetin-1334
24 moracizine-7297
25 mexiletine-4338
26 minoxidil-1496
27 methocarbamol-2274
28 merbromin-2577
29 asalocid-3021
30 mefloquine-1364
31 labetalol-1550
32 indapamide-2322
33 hydroflumethiazide-7259
34 homochlorcyclizine-2386
35 homatropine-5058
36 harmine-1758
37 guaifenesin-3897
38 genistein-5595
39 furaltadone-4313
40 foliosidine-4295
41 fludrocortisone-2368
42 famprofazone-6029
43 cefoperazone-1627
44 astemizole-1365
45 alpha-yohimbine-5800
46 dexamethasone-5797
47 alimemazine-5881
48 cobalt chloride-379
49 alfuzosin-1586-1

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.