Gene signatures

Signatures (74) and Custom Report Builder
Title Organism Platform
1 fertilizedegg
2 spleen
3 pancreas
4 salivarygland
5 thyroid
6 mammarygland.lact.
7 brownfat
8 heart
9 skeletalmuscle
10 kidney
11 liver
12 oocyte
13 largeintestine
14 smallintestine
15 stomach
16 placenta
17 bladder
18 prostate
19 b220.bcell
20 cd4.Tcell
21 cd8.Tcell
22 lymphnode
23 embryoday10.5
24 thymus
25 macrophage
26 osteoclasts
27 mast cells
28 bone
29 testis
30 cerebralcortex
31 cortex
32 frontalcortex
33 amygdala
34 embryoday9.5
35 hippocampus
36 olfactorybulb
37 hypothalamus
38 spinalcordlower
39 substantianigra
40 preoptic
41 cerebellum
42 spinalcordupper
43 dorsalstriatum
44 dorsalrootganglion
45 embryoday8.5
46 trigeminal
47 retina
48 pituitary
49 M-1
50 c2c12
51 embryonic stem feeder layer
52 embryonic stem no feeder
53 nih 3T3
54 neuro2a
55 adiposetissue
56 embryoday7.5
57 ovary
58 trachea
59 lung
60 uterus
61 umbilicalcord
62 osteoblasts
63 adrenalgland
64 digits
65 snoutepidermis
66 epidermis
67 embryoday6.5
68 tongueepidermis
69 mainolfactoryepithelium.MOE.
70 vomeralnasalorgan.VMO.
71 septal organ
72 septum (resp epith)
73 blastocysts
74 bonemarrow

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.