| Title | Organism | Platform | |
|---|---|---|---|
| 1 | Hippocampal gene expression in aged and young HSD1 knockout mice | Mus musculus | Mus musculus |
| 2 | Age effect on normal adult brain: frontal cortical region | Homo sapiens | Homo sapiens |
| 3 | Age effect on normal adult brain: frontal cortical region | Homo sapiens | Homo sapiens |
| 4 | Neurological aging models: retinas and hippocampi | Mus musculus | Mus musculus |
| 5 | Neurological aging models: retinas and hippocampi | Mus musculus | Mus musculus |
| 6 | Age effect on the hippocampus | Mus musculus | Mus musculus |
| 7 | Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior | Mus musculus | Mus musculus |
| 8 | Age-mediated transcriptomic changes in adult mouse substantia nigra and ventral tegmental area | Mus musculus | Mus musculus |
| 9 | Brain_Aging | mouse | mouse |
| 10 | Age effect on the hippocampus | Mus musculus | Mus musculus |
Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.
Hierarchical clustering of genes based on weights from the differential expression method.
Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.
Hierarchical clustering of enriched terms from
L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.
