| Title | Organism | Platform | |
|---|---|---|---|
| 1 | Autophagy effect on the MHC class II antigenic peptide repertoire | Homo sapiens | Homo sapiens |
| 2 | Oncogenic KIT mutations induce STAT3-dependent autophagy to support cell proliferation in acute myeloid leukemia | Homo sapiens | Homo sapiens |
| 3 | Let-7 and induced autophagy | Mus musculus | Mus musculus |
| 4 | Modulation of the ATM/autophagy pathway tips the balance between senescence and apoptosis in response to 20A ligand | Homo sapiens | Homo sapiens |
| 5 | Disruption of autophagic degradation with ROC-325 antagonizes renal cell carcinoma pathogenesis | Homo sapiens | Homo sapiens |
Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.
Hierarchical clustering of genes based on weights from the differential expression method.
Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.
Hierarchical clustering of enriched terms from
L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.
