updated 35 signatures, custom report for SARS

All reports

Gene signatures

Signatures (35) and Custom Report Builder
Title Organism Platform
1 Mouse lung tissue transcriptome response to a mouse-adapted strain of SARS-CoV in wild type C57BL6/NJ mice and TLR3-/- mice Mus musculus Mus musculus
2 Mouse lung tissue transcriptome response to a mouse-adapted strain of SARS-CoV in wild type C57BL6/NJ mice and TLR3-/- mice Mus musculus Mus musculus
3 Mouse lung tissue transcriptome response to a mouse-adapted strain of SARS-CoV in wild type C57BL6/NJ mice and TLR3-/- mice Mus musculus Mus musculus
4 Mouse lung tissue transcriptome response to a mouse-adapted strain of SARS-CoV in wild type C57BL6/NJ mice and TLR3-/- mice Mus musculus Mus musculus
5 Interferon response genes as immunopathogenic correlates of SARS coronavirus infection in mice (129/S6/SvEv) Mus musculus Mus musculus
6 Interferon response genes as immunopathogenic correlates of SARS coronavirus infection in mice (129/S6/SvEv) Mus musculus Mus musculus
7 Interferon response genes as immunopathogenic correlates of SARS coronavirus infection in mice (129/S6/SvEv) Mus musculus Mus musculus
8 Interferon response genes as immunopathogenic correlates of SARS coronavirus infection in mice (129/S6/SvEv) Mus musculus Mus musculus
9 Interferon response genes as immunopathogenic correlates of SARS coronavirus infection in mice (129/S6/SvEv) Mus musculus Mus musculus
10 Interferon response genes as immunopathogenic correlates of SARS coronavirus infection in mice (129/S6/SvEv) Mus musculus Mus musculus
11 Cell host-response to infection with novel human coronavirus EMC predict potential antivirals and important differences with SARS-coronavirus. Homo sapiens Homo sapiens
12 Cell host-response to infection with novel human coronavirus EMC predict potential antivirals and important differences with SARS-coronavirus. Homo sapiens Homo sapiens
13 Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis Chlorocebus aethiops; Homo sapiens Chlorocebus aethiops; Homo sapiens
14 Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis Chlorocebus aethiops; Homo sapiens Chlorocebus aethiops; Homo sapiens
15 Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis Chlorocebus aethiops; Homo sapiens Chlorocebus aethiops; Homo sapiens
16 Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis Chlorocebus aethiops; Homo sapiens Chlorocebus aethiops; Homo sapiens
17 Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis Chlorocebus aethiops; Homo sapiens Chlorocebus aethiops; Homo sapiens
18 Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis Chlorocebus aethiops; Homo sapiens Chlorocebus aethiops; Homo sapiens
19 Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis Chlorocebus aethiops; Homo sapiens Chlorocebus aethiops; Homo sapiens
20 Transcriptomic analysis of host response to mouse-adapted SARS virus in wild type, STAT1 -/-, and IFNAR1 -/- mouse genetic backgrounds Mus musculus Mus musculus
21 Transcriptomic analysis of host response to mouse-adapted SARS virus in wild type, STAT1 -/-, and IFNAR1 -/- mouse genetic backgrounds Mus musculus Mus musculus
22 Transcriptomic analysis of host response to mouse-adapted SARS virus in wild type, STAT1 -/-, and IFNAR1 -/- mouse genetic backgrounds Mus musculus Mus musculus
23 Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells against SARS-CoV and DOHV infection Homo sapiens Homo sapiens
24 Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells against SARS-CoV and DOHV infection Homo sapiens Homo sapiens
25 Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells against SARS-CoV and DOHV infection Homo sapiens Homo sapiens
26 Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells against SARS-CoV and DOHV infection Homo sapiens Homo sapiens
27 Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells against SARS-CoV and DOHV infection Homo sapiens Homo sapiens
28 Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells against SARS-CoV and DOHV infection Homo sapiens Homo sapiens
29 Severe acute respiratory syndrome expression profile Homo sapiens Homo sapiens
30 SHAE003: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures. Homo sapiens Homo sapiens
31 SHAE003: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures. Homo sapiens Homo sapiens
32 SHAE003: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures. Homo sapiens Homo sapiens
33 SHAE003: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures. Homo sapiens Homo sapiens
34 SHAE003: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures. Homo sapiens Homo sapiens
35 SHAE003: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures. Homo sapiens Homo sapiens

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.