ligands, custom report for LIGANDS

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Gene signatures

Signatures (49) and Custom Report Builder
Title Organism Platform
1 Primary keratinocyte response to in vitro cytokine exposure Homo sapiens Homo sapiens
2 BT20_IGF1
3 BT20_IGF1
4 BT20_IGF1
5 BT20_IGF1
6 BT20_IGF1
7 BT20_IGF1
8 BT20_IGF1
9 BT20_IGF1
10 HS578T_IGF1
11 HS578T_IGF1
12 HS578T_IGF1
13 HS578T_IGF1
14 HS578T_IGF1
15 HS578T_IGF1
16 HS578T_IGF1
17 HS578T_IGF1
18 MCF10A_IGF1
19 MCF10A_IGF1
20 MCF10A_IGF1
21 MCF10A_IGF1
22 MCF10A_IGF1
23 MCF10A_IGF1
24 MCF10A_IGF1
25 MCF10A_IGF1
26 MCF7_IGF1
27 MCF7_IGF1
28 MCF7_IGF1
29 MCF7_IGF1
30 MCF7_IGF1
31 MCF7_IGF1
32 MCF7_IGF1
33 MCF7_IGF1
34 MDAMB231_IGF1
35 MDAMB231_IGF1
36 MDAMB231_IGF1
37 MDAMB231_IGF1
38 MDAMB231_IGF1
39 MDAMB231_IGF1
40 MDAMB231_IGF1
41 MDAMB231_IGF1
42 SKBR3_IGF1
43 SKBR3_IGF1
44 SKBR3_IGF1
45 SKBR3_IGF1
46 SKBR3_IGF1
47 SKBR3_IGF1
48 SKBR3_IGF1
49 SKBR3_IGF1

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.