DEXAMETHASONE report

Categorized using metadata field Cell

All reports

Gene signatures

Signatures (86) and Custom Report Builder
Title Organism Platform
1 Dexamethasone effect on glucocorticoid-resistant and -sensitive lymphoblastic leukemia cell lines Homo sapiens Homo sapiens
2 Dexamethasone effect on glucocorticoid-resistant and -sensitive lymphoblastic leukemia cell lines Homo sapiens Homo sapiens
3 Dexamethasone effect on fetal chondrocytes in vitro: time course Mus musculus Mus musculus
4 Dexamethasone effect on fetal chondrocytes in vitro: time course Mus musculus Mus musculus
5 Dexamethasone effect on cultured airway smooth muscle cells: time course Homo sapiens Homo sapiens
6 In vivo glucocorticoid effect on non-leukemic peripheral blood lymphocytes Homo sapiens Homo sapiens
7 In vivo glucocorticoid effect on non-leukemic peripheral blood lymphocytes Homo sapiens Homo sapiens
8 In vivo glucocorticoid effect on non-leukemic peripheral blood lymphocytes Homo sapiens Homo sapiens
9 Lung response to chronic and acute exposure to ingested arsenic Mus musculus Mus musculus
10 Cigarette smoke effect on tracheal explants Rattus norvegicus Rattus norvegicus
11 Cigarette smoke effect on tracheal explants Rattus norvegicus Rattus norvegicus
12 Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course Homo sapiens Homo sapiens
13 Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course Homo sapiens Homo sapiens
14 Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course Homo sapiens Homo sapiens
15 Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course Homo sapiens Homo sapiens
16 Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course Homo sapiens Homo sapiens
17 Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course Homo sapiens Homo sapiens
18 Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course Homo sapiens Homo sapiens
19 Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course Homo sapiens Homo sapiens
20 Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course Homo sapiens Homo sapiens
21 Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course Homo sapiens Homo sapiens
22 Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course Homo sapiens Homo sapiens
23 Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course Homo sapiens Homo sapiens
24 Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course Homo sapiens Homo sapiens
25 Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course Homo sapiens Homo sapiens
26 Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course Homo sapiens Homo sapiens
27 Antenatal steroid effect on the placenta Mus musculus Mus musculus
28 CD4/CD8 double positive thymocyte response to glucocorticoid Mus musculus Mus musculus
29 Expression data from glucocorticoid-treated acute lymphoblastic leukemia cell line, RS4;11 Homo sapiens Homo sapiens
30 Expression data from glucocorticoid-treated acute lymphoblastic leukemia cell line, RS4;11 Homo sapiens Homo sapiens
31 Genome-wide analysis of dexamethasone treated substrates in HeLa cell Homo sapiens Homo sapiens
32 Glucocorticoid-induced reversal of IL1b stumulated gene expression in OE-E6/7 cells Homo sapiens Homo sapiens
33 Comparative analysis of gene expression profiles in lymphoma cells after treatment by Dexamethasone or CpdA Homo sapiens Homo sapiens
34 Dexamethasone regulation of mRNAs in astrocytes in vitro Mus musculus Mus musculus
35 Dexamethasone regulation of mRNAs in astrocytes in vitro Mus musculus Mus musculus
36 Dexamethasone regulation of mRNAs in astrocytes in vitro Mus musculus Mus musculus
37 Dexamethasone regulation of mRNAs in astrocytes in vitro Mus musculus Mus musculus
38 Dexamethasone regulation of mRNAs in astrocytes in vitro Mus musculus Mus musculus
39 Dexamethasone regulation of mRNAs in astrocytes in vitro Mus musculus Mus musculus
40 Dexamethasone regulation of mRNAs in astrocytes in vitro Mus musculus Mus musculus
41 Dexamethasone regulation of mRNAs in astrocytes in vitro Mus musculus Mus musculus
42 Drug Matrix Data - Affymetrix Arrays Rattus norvegicus Rattus norvegicus
43 Drug Matrix Data - Affymetrix Arrays Rattus norvegicus Rattus norvegicus
44 Exposure of rat to a variety of toxicants, liver assayed by Affymetrix microarray Rattus norvegicus Rattus norvegicus
45 In vitro exposure of rat hepatocytes to a variety of toxicants, assayed by Affymetrix microarray Rattus norvegicus Rattus norvegicus
46 In vitro exposure of rat hepatocytes to a variety of toxicants, assayed by Affymetrix microarray Rattus norvegicus Rattus norvegicus
47 Exposure of rat to a variety of toxicants, kidney assayed by Affymetrix microarray Rattus norvegicus Rattus norvegicus
48 Exposure of rat to a variety of toxicants, kidney assayed by Affymetrix microarray Rattus norvegicus Rattus norvegicus
49 Effects of dexamethasone on cultured lung explant Mus musculus Mus musculus
50 Expression data from dexamethasone treated mouse embryonic neural progenitor/stem cells isolated from wild type C57Bl/6 or caveolin-1 knockout mice Mus musculus Mus musculus
51 Expression data from dexamethasone treated mouse embryonic neural progenitor/stem cells isolated from wild type C57Bl/6 or caveolin-1 knockout mice Mus musculus Mus musculus
52 Myeloid cells or lung fibroblasts treated with IL-4 or IL-13 Homo sapiens Homo sapiens
53 Hes1 and Liver Glucocorticoid Signaling Mus musculus Mus musculus
54 Hes1 and Liver Glucocorticoid Signaling Mus musculus Mus musculus
55 SUMOylation Regulates the Anti-Proliferative Gene Signature Programs of Glucocorticoid Receptor (HEK293) Homo sapiens Homo sapiens
56 SUMOylation Regulates the Anti-Proliferative Gene Signature Programs of Glucocorticoid Receptor (HEK293) Homo sapiens Homo sapiens
57 Alveoli septation inhibition and protection Mus musculus Mus musculus
58 Comparative analysis of gene expression profiles in lymphoma cells after treatment by Dexamethasone or CpdA Homo sapiens Homo sapiens
59 Exposure of rat to a variety of toxicants, liver assayed by Affymetrix microarray Rattus norvegicus Rattus norvegicus
60 SUMOylation Regulates the Anti-Proliferative Gene Signature Programs of Glucocorticoid Receptor (U2Os cell line) Homo sapiens Homo sapiens
61 SUMOylation Regulates the Anti-Proliferative Gene Signature Programs of Glucocorticoid Receptor (U2Os cell line) Homo sapiens Homo sapiens
62 Expression of DND41 cell lines treated with 1µM Dexamethasone for 24h after shPTEN infection Homo sapiens Homo sapiens
63 Expression of DND41 cell lines treated with 1µM Dexamethasone for 24h after shPTEN infection Homo sapiens Homo sapiens
64 Expression of DND41 cell lines treated with 1µM Dexamethasone for 24h after shPTEN infection Homo sapiens Homo sapiens
65 Effect of chronic glucocorticoid (GC) treatment on neonatal mouse whole cerebellum and whole lung Mus musculus Mus musculus
66 Effect of chronic glucocorticoid (GC) treatment on neonatal mouse whole cerebellum and whole lung Mus musculus Mus musculus
67 Glucocorticoid Receptor Confers Resistance to Anti-Androgens by Bypassing Androgen Receptor Blockade. Homo sapiens Homo sapiens
68 Glucocorticoid Receptor Confers Resistance to Anti-Androgens by Bypassing Androgen Receptor Blockade. Homo sapiens Homo sapiens
69 Microarray Study Reveals Hormone-Modulated Gene Transcription During Human Podocyte Differentiation Homo sapiens Homo sapiens
70 Characterization of Glucocorticoid Receptor (GR) in Mouse Liver Mus musculus Mus musculus
71 Expression data from a 24h time series of dexamethasone treatment for mouse bone marrow derived macrophages Mus musculus Mus musculus
72 Expression data from a 24h time series of dexamethasone treatment for mouse bone marrow derived macrophages Mus musculus Mus musculus
73 Expression data from a 24h time series of dexamethasone treatment for mouse bone marrow derived macrophages Mus musculus Mus musculus
74 Expression data from a 24h time series of dexamethasone treatment for mouse bone marrow derived macrophages Mus musculus Mus musculus
75 Expression data from a 24h time series of dexamethasone treatment for mouse bone marrow derived macrophages Mus musculus Mus musculus
76 KLF15- and glucocorticoid-dependent transcriptional responses in mouse muscle. Mus musculus Mus musculus
77 KLF15- and glucocorticoid-dependent transcriptional responses in mouse muscle. Mus musculus Mus musculus
78 Distinct genome-wide, gene-specific selectivity patterns of four glucocorticoid receptor coregulators Homo sapiens Homo sapiens
79 Ectopic microRNA-150 transcription mimics GR therapy response in GC sensitive MM1S multiple myeloma cells but fails to overcome GC resistance in MM1R cells Homo sapiens Homo sapiens
80 Ectopic microRNA-150 transcription mimics GR therapy response in GC sensitive MM1S multiple myeloma cells but fails to overcome GC resistance in MM1R cells Homo sapiens Homo sapiens
81 Transcriptional responses of mouse adipocytes during insulin resistance Mus musculus Mus musculus
82 Transcriptional responses of mouse adipocytes during insulin resistance Mus musculus Mus musculus
83 Glucocorticoid-induced reversal of IL1b stumulated gene expression in OE-E6/7 cells Homo sapiens Homo sapiens
84 Transcriptional responses of mouse adipocytes during insulin resistance Mus musculus Mus musculus
85 Genome-wide analysis of dexamethasone treated substrates in HeLa cell Homo sapiens Homo sapiens
86 GR and ER co-activation alters the expression of differentiation genes and associates with improved ER+ breast cancer outcome Homo sapiens Homo sapiens

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.