Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from KEGG_2015 MGI_Mammalian_Phenotype_Level_4 ENCODE_TF_ChIP-seq_2015 Single_Gene_Perturbations_from_GEO_up

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.