SCHIZOPHRENIA report

Categorized using metadata field disease

All reports

Gene signatures

Signatures (18) and Custom Report Builder
Title Organism Platform
1 Schizophrenia: postmortem superior temporal cortex Homo sapiens Homo sapiens
2 Schizophrenia: postmortem superior temporal cortex Homo sapiens Homo sapiens
3 Induced pluripotent stem cell-derived neurons from schizophrenia patients Homo sapiens Homo sapiens
4 Induced pluripotent stem cell-derived neurons from schizophrenia patients Homo sapiens Homo sapiens
5 Schizophrenia: endothelial and neuronal cells from postmortem dorsolateral prefrontal cortex tissue Homo sapiens Homo sapiens
6 Schizophrenia: endothelial and neuronal cells from postmortem dorsolateral prefrontal cortex tissue Homo sapiens Homo sapiens
7 Schizophrenia: endothelial and neuronal cells from postmortem dorsolateral prefrontal cortex tissue Homo sapiens Homo sapiens
8 Cerebellar cortex in schizophrenia Homo sapiens Homo sapiens
9 Transcriptomic profiles of skin fibroblasts from patients affected by schizophrenia and controls Homo sapiens Homo sapiens
10 Gene expression profiles of patients with schizophrenia, bipolar disorder and healthy controls Homo sapiens Homo sapiens
11 Microarray profiling of PFC, HPC and STR from subjects with schizophrenia, bipolar, MDD or control Homo sapiens Homo sapiens
12 Microarray profiling of PFC, HPC and STR from subjects with schizophrenia, bipolar, MDD or control Homo sapiens Homo sapiens
13 Microarray profiling of PFC, HPC and STR from subjects with schizophrenia, bipolar, MDD or control Homo sapiens Homo sapiens
14 Comparing Control and Schizophrenic hiPSC-derived NPCs Homo sapiens Homo sapiens
15 Marked Reduction of AKT1 Expression and Deregulation of AKT1-associated Pathways in Peripheral Blood Mononuclear Cells of Schizophrenia Patients Homo sapiens Homo sapiens
16 Marked Reduction of AKT1 Expression and Deregulation of AKT1-associated Pathways in Peripheral Blood Mononuclear Cells of Schizophrenia Patients Homo sapiens Homo sapiens
17 Induced pluripotent stem cell-derived neurons from schizophrenia patients Homo sapiens Homo sapiens
18 Gene Expression Profiles in BA46 of Subjects with Schizophrenia and Matched Controls Homo sapiens Homo sapiens

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.