VEMURAFENIB report

Categorized using metadata field disease

All reports

Gene signatures

Signatures (16) and Custom Report Builder
Title Organism Platform
1 Oncogenic BRAF harboring melanoma cell line response to BRAF inhibition Homo sapiens Homo sapiens
2 Oncogenic BRAF harboring melanoma cell line response to BRAF inhibition Homo sapiens Homo sapiens
3 Spectrum, clinical correlates and clinical implications of BRAF-inhibitor resistance mechanisms in melanoma Homo sapiens Homo sapiens
4 Braf inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia, and exert anti-leukemic activity Homo sapiens Homo sapiens
5 Gene expression in Vemurafenib-treated A375 and A2058 melanoma cell lines Homo sapiens Homo sapiens
6 Gene expression in Vemurafenib-treated A375 and A2058 melanoma cell lines Homo sapiens Homo sapiens
7 Oncogenic BRAF harboring melanoma cell line response to BRAF inhibition Homo sapiens Homo sapiens
8 Braf inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia, and exert anti-leukemic activity Homo sapiens Homo sapiens
9 Braf inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia, and exert anti-leukemic activity Homo sapiens Homo sapiens
10 Parent vs. Induced drug tolerant cells Microarray Analysis Homo sapiens Homo sapiens
11 Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas. Homo sapiens Homo sapiens
12 Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas. Homo sapiens Homo sapiens
13 Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas. Homo sapiens Homo sapiens
14 Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas. Homo sapiens Homo sapiens
15 Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas. Homo sapiens Homo sapiens
16 Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas. Homo sapiens Homo sapiens

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.