DTOXS report

Categorized using metadata field drug

All reports

Gene signatures

Signatures (77) and Custom Report Builder
Title Organism Platform
1 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Alendronate (ALE)_48 hours
2 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Paroxetine (PAR)_48 hours
3 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Sorafenib (SOR) and Ursodeoxycholic acid (URS)_48 hours
4 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Sunitinib (SUN) and Alendronate (ALE)_48 hours
5 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Sunitinib (SUN) and Domperidone (DOM)_48 hours
6 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Sunitinib (SUN) and Paroxetine (PAR)_48 hours
7 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Sunitinib (SUN) and Ursodeoxycholic acid (URS)_48 hours
8 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Sunitinib (SUN)_48 hours
9 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Trastuzumab (TRS) and Domperidone (DOM)_48 hours
10 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Trastuzumab (TRS) and Loperamide (LOP)_48 hours
11 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Trastuzumab (TRS) and Ursodeoxycholic acid (URS)_48 hours
12 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Amiodarone (AMI)_48 hours
13 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Trastuzumab (TRS)_48 hours
14 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Afatinib (AFA)_48 hours
15 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Bosutinib (BOS)_48 hours
16 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Cefuroxime (CEF)_48 hours
17 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Cytarabine (CYT)_48 hours
18 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Dasatinib (DAS) and Cytarabine (CYT)_48 hours
19 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Dasatinib (DAS) and Methotrexate (MTX)_48 hours
20 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Dasatinib (DAS)_48 hours
21 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Erlotinib (ERL) and Cefuroxime (CEF)_48 hours
22 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Erlotinib (ERL)_48 hours
23 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Diclofenac (DIC)_48 hours
24 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Methotrexate (MTX)_48 hours
25 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Pazopanib (PAZ)_48 hours
26 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Ruxolitinib (RUX)_48 hours
27 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Sorafenib (SOR) and Entecavir (ENT)_48 hours
28 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Sorafenib (SOR) and Ursodeoxycholic acid (URS)_48 hours
29 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Sorafenib (SOR)_48 hours
30 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Sunitinib (SUN) and Prednisiolone (PRE)_48 hours
31 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Trastuzumab (TRS)_48 hours
32 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Vandetanib (VAN)_48 hours
33 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Amiodarone (AMI)_48 hours
34 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Domperidone (DOM)_48 hours
35 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Flecainide (FLE)_48 hours
36 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Milrinone (MIL)_48 hours
37 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Bosutinib (BOS)_48 hours
38 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Domperidone (DOM)_48 hours
39 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Diethylpropion (DTP)_48 hours
40 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Entecavir (ENT)_48 hours
41 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Lapatinib (LAP) and Ursodeoxycholic acid (URS)_48 hours
42 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Lapatinib (LAP)_48 hours
43 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Sorafenib (SOR) and Diethylpropion (DTP)_48 hours
44 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Sorafenib (SOR) and Entecavir (ENT)_48 hours
45 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Diethylpropion (DTP)_48 hours
46 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Sorafenib (SOR) and Ursodeoxycholic acid (URS)_48 hours
47 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Sorafenib (SOR)_48 hours
48 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Sunitinib (SUN) and Loperamide (LOP)_48 hours
49 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Sunitinib (SUN) and Ursodeoxycholic acid (URS)_48 hours
50 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Tofacitinib (TOF)_48 hours
51 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Trastuzumab (TRS) and Domperidone (DOM)_48 hours
52 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Trastuzumab (TRS) and Ursodeoxycholic acid (URS)_48 hours
53 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Trastuzumab (TRS)_48 hours
54 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Ursodeoxycholic acid (URS)_48 hours
55 PromoCell Cardiomyocyte, Line B (LPC-1001)_drug_Vandetanib (VAN)_48 hours
56 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Entecavir (ENT)_48 hours
57 PromoCell Cardiomyocyte, Line D (LPC-1001)_drug_Flecainide (FLE)_48 hours
58 PromoCell Cardiomyocyte, Line D (LPC-1001)_drug_Trastuzumab (TRS) and Ursodeoxycholic acid (URS)_48 hours
59 PromoCell Cardiomyocyte, Line D (LPC-1001)_drug_Trastuzumab (TRS)_48 hours
60 PromoCell Cardiomyocyte, Line D (LPC-1001)_drug_Cyclosporine (CYC)_48 hours
61 PromoCell Cardiomyocyte, Line D (LPC-1001)_drug_Domperidone (DOM)_48 hours
62 PromoCell Cardiomyocyte, Line D (LPC-1001)_drug_Diethylpropion (DTP)_48 hours
63 PromoCell Cardiomyocyte, Line D (LPC-1001)_drug_Imatinib (IMA) and Cyclosporine (CYC)_48 hours
64 PromoCell Cardiomyocyte, Line D (LPC-1001)_drug_Lapatinib (LAP)_48 hours
65 PromoCell Cardiomyocyte, Line D (LPC-1001)_drug_Loperamide (LOP)_48 hours
66 PromoCell Cardiomyocyte, Line D (LPC-1001)_drug_Sorafenib (SOR) and Ursodeoxycholic acid (URS)_48 hours
67 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Flecainide (FLE)_48 hours
68 PromoCell Cardiomyocyte, Line D (LPC-1001)_drug_Sunitinib (SUN) and Loperamide (LOP)_48 hours
69 PromoCell Cardiomyocyte, Line D (LPC-1001)_drug_Trastuzumab (TRS) and Domperidone (DOM)_48 hours
70 PromoCell Cardiomyocyte, Line D (LPC-1001)_drug_Trastuzumab (TRS) and Loperamide (LOP)_48 hours
71 PromoCell Cardiomyocyte, Line D (LPC-1001)_drug_Ursodeoxycholic acid (URS)_48 hours
72 PromoCell Cardiomyocyte, Line E (LPC-1001)_drug_Amiodarone (AMI)_48 hours
73 PromoCell Cardiomyocyte, Line E (LPC-1001)_drug_Flecainide (FLE)_48 hours
74 PromoCell Cardiomyocyte, Line E (LPC-1001)_drug_Milrinone (MIL)_48 hours
75 PromoCell Cardiomyocyte, Line E (LPC-1001)_drug_Sunitinib (SUN) and Ursodeoxycholic acid (URS)_48 hours
76 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Imatinib (IMA)_48 hours
77 PromoCell Cardiomyocyte, Line A (LPC-1001)_drug_Loperamide (LOP)_48 hours

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.