lncHUB: Functional predictions of human long non-coding RNAs based on gene co-expression data



Long non-coding RNAs (lncRNAs) are RNA transcripts of length exceeding 200 nucleotides that are not translated into protein. It is estimated that there are thousands of lncRNAs encoded in the human genome and most of them serve important functions. So far, knowledge about their role within the cell, and their association with normal physiology and human disease is mostly unknown. lncHUB provides predictions for such associations for 3,729 lncRNAs based on data from mRNA co-expression. Specifically, we utilize gene expression data from 11,284 TCGA RNA-seq samples processed by Recount2 to make gene function predictions using the same method implemented to provide gene function predictions by Geneshot.

Instructions

Select a long non-coding RNA from the search box and submit it to receive ranked lists of predictions of putative KEGG pathway membership, GO biological processes, and knockout mice phenotypes. lncHUB also lists the top correlated genes based gene expression for each submitted lncRNA. The max Pathway, max Phenotype, max Process, and max Gene in the table are the maximal scores for the lncRNA for each domain.

lncRNAs currently supported



EnrichrBot

EnrichrBot is a Twitter bot that will post information about understudied genes in regular intervals. It is using the lncHUB as a reference for information regarding lncRNAs.
https://twitter.com/BotEnrichr

You can explore other understudied genes at:
https://amp.pharm.mssm.edu/geneshot.

lncHUB: Functional predictions of human long non-coding RNAs based on gene co-expression data



Long non-coding RNAs (lncRNAs) are defined as RNA transcripts of length exceeding 200 nucleotides that are not translated into protein. While it is estimated that there are over 15,000 lncRNAs encoded in the human genome, whereby many of them serve important function, knowledge about their role in the cell and their association with normal physiology and human disease is mostly unknown. lncHUB provides predictions for such associations based on data from mRNA co-expression.

Instructions

Select a long non-coding RNA from the search box and submit it to see ranked predictions of its putative functions. lncHUB also lists the top correlated genes based gene expression for each submitted lncRNA.