AADAC Gene

HGNC Family	Lipases, Arylacetamide deacetylase family (AADAC)
Name	arylacetamide deacetylase
Description	Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Arylacetamide deacetylase (AADAC) is a microsomal serine hydrolase that plays a multifaceted role in both xenobiotic and lipid metabolism. Its classical function in drug metabolism involves the deacetylation of clinically important compounds. For example, recombinant human AADAC efficiently hydrolyzes rifamycins—thereby reducing their cytotoxic potential and modulating CYP3A4‐dependent induction pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, AADAC is responsible for the hydrolysis of ketoconazole and abiraterone acetate, reactions that not only affect drug clearance but also influence adverse hepatocellular outcomes; indeed, genetic deletion or pharmacological inhibition of AADAC in animal models exacerbates ketoconazole‐induced liver injury"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and contributes to altered exposure in the case of abiraterone acetate."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Genetic polymorphisms and copy number variations within the AADAC gene further dictate interindividual differences in the metabolism of drugs such as flutamide, phenacetin, and rifamycins, and have been implicated as susceptibility factors in neuropsychiatric conditions including Tourette syndrome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond drug metabolism, emerging evidence indicates that AADAC also contributes to lipid homeostasis. In hepatic models, overexpression of AADAC reduces intracellular triglyceride content, decreases apolipoprotein B secretion, and enhances fatty acid oxidation—thereby impacting very low‐density lipoprotein production."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Moreover, in vascular smooth muscle cells, higher AADAC expression correlates with reduced lipid droplet accumulation and appears to protect against cardiovascular disease in type 2 diabetes patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Regulation of AADAC activity is further influenced by post‐translational modifications; for instance, proper N‐glycosylation is critical for correct protein folding and optimal enzymatic function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In preclinical research, species‐ and tissue‐specific differences in AADAC expression and activity have been documented; such variations are important when extrapolating metabolic data from animal studies to humans."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Furthermore, selective inhibition of AADAC by certain natural compounds (e.g., epicatechin gallate and epigallocatechin gallate) has been demonstrated, suggesting that dietary components may modulate its activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Finally, intestinal regulation of AADAC—modulated by cytokines such as IL-10—can alter the metabolic activation of prodrugs (for instance, vicagrel), thereby affecting pharmacological efficacy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the multifunctional nature of AADAC as a critical enzyme at the intersection of drug detoxification and lipid metabolism, with significant implications for pharmacotherapy, interindividual variability in drug response, and disease susceptibility.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Akinori Nakajima, Tatsuki Fukami, Yuki Kobayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human arylacetamide deacetylase is responsible for deacetylation of rifamycins: rifampicin, rifabutin, and rifapentine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcp.2011.08.003"}], "href": "https://doi.org/10.1016/j.bcp.2011.08.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21856291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21856291"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tatsuki Fukami, Azumi Iida, Keigo Konishi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcp.2016.07.007"}], "href": "https://doi.org/10.1016/j.bcp.2016.07.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27422753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27422753"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mai Nagaoka, Tatsuki Fukami, Fumiya Kisui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arylacetamide deacetylase knockout mice are sensitive to ketoconazole-induced hepatotoxicity and adrenal insufficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcp.2021.114842"}], "href": "https://doi.org/10.1016/j.bcp.2021.114842"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34798123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34798123"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yoshiyuki Sakai, Tatsuki Fukami, Mai Nagaoka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arylacetamide deacetylase as a determinant of the hydrolysis and activation of abiraterone acetate in mice and humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2021.119896"}], "href": "https://doi.org/10.1016/j.lfs.2021.119896"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34450168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34450168"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Birgitte Bertelsen, Hreinn Stefánsson, Lars Riff Jensen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2015.08.027"}], "href": "https://doi.org/10.1016/j.biopsych.2015.08.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26444075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26444075"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mai Shimizu, Tatsuki Fukami, Yuki Kobayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Metab Dispos (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/dmd.112.044883"}], "href": "https://doi.org/10.1124/dmd.112.044883"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22415931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22415931"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lamei Yuan, Wen Zheng, Zuocheng Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of the AADAC gene and Tourette syndrome in a Han Chinese cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2017.12.034"}], "href": "https://doi.org/10.1016/j.neulet.2017.12.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29253601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29253601"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Vivien Lo, Bruce Erickson, Michaela Thomason-Hughes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arylacetamide deacetylase attenuates fatty-acid-induced triacylglycerol accumulation in rat hepatoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M000596"}], "href": "https://doi.org/10.1194/jlr.M000596"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19654421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19654421"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mahra Nourbakhsh, Donna N Douglas, Christopher Hao Pu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hepatol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jhep.2013.03.022"}], "href": "https://doi.org/10.1016/j.jhep.2013.03.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23542347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23542347"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Takafumi Toyohara, Filip Roudnicky, Mary H C Florido, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stem Cell (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stem.2020.04.018"}], "href": "https://doi.org/10.1016/j.stem.2020.04.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32413331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32413331"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kyotaka Muta, Tatsuki Fukami, Miki Nakajima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcp.2013.10.001"}], "href": "https://doi.org/10.1016/j.bcp.2013.10.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24125761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24125761"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Fumiya Kisui, Tatsuki Fukami, Masataka Nakano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Strain and sex differences in drug hydrolase activities in rodent livers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pharm Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejps.2019.105143"}], "href": "https://doi.org/10.1016/j.ejps.2019.105143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31726091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31726091"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Shiori Honda, Tatsuki Fukami, Takuya Tsujiguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hydrolase activities of cynomolgus monkey liver microsomes and recombinant CES1, CES2, and AADAC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pharm Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejps.2021.105807"}], "href": "https://doi.org/10.1016/j.ejps.2021.105807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33722734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33722734"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Kaori Yasuda, Kazuki Watanabe, Tatsuki Fukami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epicatechin gallate and epigallocatechin gallate are potent inhibitors of human arylacetamide deacetylase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Metab Pharmacokinet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dmpk.2021.100397"}], "href": "https://doi.org/10.1016/j.dmpk.2021.100397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34171773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34171773"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yu-Meng Jia, Huan Zhou, Ting Tai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced responsiveness of platelets to vicagrel in IL-10-deficient mice through STAT3-dependent up-regulation of the hydrolase arylacetamide deacetylase in the intestine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Pharmacol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bph.14646"}], "href": "https://doi.org/10.1111/bph.14646"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30825385"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30825385"}]}]}]}
Synonyms	CES5A1, DAC
Proteins	AAAD_HUMAN
NCBI Gene ID	13
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

AADAC has 4,010 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for AADAC from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

AADAC Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by AADAC gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of AADAC gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of AADAC gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of AADAC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AADAC gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of AADAC gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AADAC gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AADAC gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of AADAC gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of AADAC gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of AADAC gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with AADAC gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AADAC gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of AADAC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of AADAC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of AADAC gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of AADAC gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing AADAC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing AADAC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with AADAC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with AADAC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of AADAC gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with AADAC gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with AADAC gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with AADAC gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by AADAC gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for AADAC protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving AADAC gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with AADAC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with AADAC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with AADAC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with AADAC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at AADAC gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AADAC gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of AADAC gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing AADAC from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with AADAC gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with AADAC gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of AADAC gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with AADAC gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.