ABCA2 Gene

HGNC Family	ATP binding cassette transporters (ABC)
Name	ATP-binding cassette, sub-family A (ABC1), member 2
Description	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ABCA2, a member of the ATP‐binding cassette A subfamily, is predominantly expressed in neural tissues and appears to play multifaceted roles in both normal physiology and disease. In the brain, ABCA2 is localized mainly to late endosomal/lysosomal compartments in oligodendrocytes and certain neurons, suggesting that it participates in the intracellular transport and homeostasis of lipids, notably sphingolipids and cholesterol, which are critical for proper myelin membrane formation and compaction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Consistent with this view, deletion of the gene in mice results in altered myelin lipid composition, abnormal myelin compaction, tremor, and other neurological phenotypes, supporting a physiological role in neural lipid export and myelin homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In cell culture systems, overexpression of ABCA2 has been associated with modulation of amyloid precursor protein (APP) processing and increased generation of N‐terminally truncated amyloid‐β peptides, findings that implicate ABCA2 in Alzheimer’s disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Genetic studies further support a link between ABCA2 and Alzheimer’s disease; specific polymorphisms in the gene have been associated with an increased risk of early‐onset Alzheimer’s in certain populations."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in neural physiology, elevated ABCA2 expression has been observed in various malignancies. In hematological cancers such as pediatric acute lymphoblastic leukemia—and more broadly in multidrug‐resistant tumor models—ABCA2 is upregulated, and its expression correlates with poor treatment response, suggesting that it may contribute to drug efflux and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": " In addition, studies in mesothelioma models indicate that inhibition of signaling pathways that regulate the expression of a panel of ABC transporters—including ABCA2—can modulate resistance to cytotoxic drugs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Regulation of ABCA2 expression is complex and involves multiple transcriptional mechanisms. Promoter analyses have identified overlapping GC‐rich elements that bind factors such as Sp1 and EGR-1, while emerging data also point to regulation by developmental and oncogenic pathways, including Hedgehog-GLI signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Moreover, studies demonstrating the presence of alternative first exons suggest tissue-specific regulation, as ABCA2 transcripts are most abundant in peripheral blood leukocytes and neural cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}, {"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, current findings indicate that ABCA2 functions as a lipid transporter critical for neuronal lipid homeostasis and myelin integrity, while also contributing to the modulation of APP processing and amyloid–β generation in Alzheimer’s disease. In parallel, its elevated expression in certain cancers associates it with chemoresistance, making ABCA2 a potential target for therapeutic intervention in both neurodegenerative and oncologic disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ramzi Shawahna, Yasuo Uchida, Xavier Declèves, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharm (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/mp200129p"}], "href": "https://doi.org/10.1021/mp200129p"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21707071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21707071"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "G Schmitz, W E Kaminski "}, {"type": "b", "children": [{"type": "t", "text": "ABCA2: a candidate regulator of neural transmembrane lipid transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-002-8508-5"}], "href": "https://doi.org/10.1007/s00018-002-8508-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12363033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12363033"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hiromichi Sakai, Yukiko Tanaka, Makoto Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ABCA2 deficiency results in abnormal sphingolipid metabolism in mouse brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M611056200"}], "href": "https://doi.org/10.1074/jbc.M611056200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17488728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17488728"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jody T Mack, Vladimir Beljanski, Athena M Soulika, et al. "}, {"type": "b", "children": [{"type": "t", "text": "\"Skittish\" Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01824-06"}], "href": "https://doi.org/10.1128/MCB.01824-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17060448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17060448"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Warren Davis "}, {"type": "b", "children": [{"type": "t", "text": "The ATP-binding cassette transporter-2 (ABCA2) regulates esterification of plasma membrane cholesterol by modulation of sphingolipid metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbalip.2013.10.019"}], "href": "https://doi.org/10.1016/j.bbalip.2013.10.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24201375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24201375"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Woojin Scott Kim, Aldwin Suryo Rahmanto, Alvin Kamili, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M607831200"}], "href": "https://doi.org/10.1074/jbc.M607831200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17121837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17121837"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Vasiliki Michaki, Francesc X Guix, Krist'l Vennekens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.288258"}], "href": "https://doi.org/10.1074/jbc.M111.288258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22086926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22086926"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sandrine Macé, Emmanuelle Cousin, Sylvain Ricard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Dis (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nbd.2004.09.011"}], "href": "https://doi.org/10.1016/j.nbd.2004.09.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15649702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15649702"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "M Axel Wollmer, Elisabeth Kapaki, Martin Hersberger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.30345"}], "href": "https://doi.org/10.1002/ajmg.b.30345"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16752360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16752360"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Soheila Rahgozar, Alireza Moafi, Marjan Abedi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "mRNA expression profile of multidrug-resistant genes in acute lymphoblastic leukemia of children, a prognostic value for ABCA3 and ABCA2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cbt.26603"}], "href": "https://doi.org/10.4161/cbt.26603"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24145140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24145140"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Elaheh S Ghodousi, Soheila Rahgozar "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-326 and microRNA-200c: Two novel biomarkers for diagnosis and prognosis of pediatric acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.26800"}], "href": "https://doi.org/10.1002/jcb.26800"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29630744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29630744"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kristina E Ile, Warren Davis, Jonathan T Boyd, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel first exon of the human ABCA2 transporter gene encoding a unique N-terminus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbaexp.2004.01.007"}], "href": "https://doi.org/10.1016/j.bbaexp.2004.01.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15093135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15093135"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Arti Shukla, Jedd M Hillegass, Maximilian B MacPherson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-9-314"}], "href": "https://doi.org/10.1186/1476-4598-9-314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21159167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21159167"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Warren Davis, Zhijian J Chen, Kristina E Ile, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkg192"}], "href": "https://doi.org/10.1093/nar/gkg192"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12560508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12560508"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Agnese Po, Anna Citarella, Giuseppina Catanzaro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-70871-9"}], "href": "https://doi.org/10.1038/s41598-020-70871-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32814794"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32814794"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yan Wang, Katsuya Yamada, Yukiko Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of ABCA2 protein in human vestibular schwannoma and peripheral nerve."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurol Sci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jns.2005.01.016"}], "href": "https://doi.org/10.1016/j.jns.2005.01.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15850583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15850583"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Vijay Alla, Bhavani S Kowtharapu, David Engelmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "E2F1 confers anticancer drug resistance by targeting ABC transporter family members and Bcl-2 via the p73/DNp73-miR-205 circuitry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.21476"}], "href": "https://doi.org/10.4161/cc.21476"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22871739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22871739"}]}]}]}
Synonyms	ABC2
Proteins	ABCA2_HUMAN
NCBI Gene ID	20
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ABCA2 has 6,445 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 123 datasets.

Click the + buttons to view associations for ABCA2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ABCA2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ABCA2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ABCA2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ABCA2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ABCA2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ABCA2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ABCA2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ABCA2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ABCA2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ABCA2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ABCA2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ABCA2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ABCA2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ABCA2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ABCA2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ABCA2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ABCA2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ABCA2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with ABCA2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ABCA2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ABCA2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ABCA2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ABCA2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ABCA2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ABCA2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ABCA2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ABCA2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ABCA2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ABCA2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ABCA2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ABCA2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving ABCA2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ABCA2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ABCA2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ABCA2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ABCA2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ABCA2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ABCA2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ABCA2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ABCA2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ABCA2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.