ABI1 Gene

Name	abl-interactor 1
Description	This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Abl interactor 1 (Abi1) is a critical adaptor protein that functions as a molecular scaffold in several multiprotein complexes regulating actin cytoskeletal dynamics. By directly interacting with WAVE family proteins, Abi1 links Rac‐GTPase activation to Arp2/3‐mediated actin nucleation, thereby promoting the formation of lamellipodia and filopodia and supporting cell migration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Abi1 also facilitates the assembly of larger signaling platforms by interacting with partners such as Nap1, PIR121, Eps8, and Sos1. In these complexes, Abi1 not only enhances WAVE complex–dependent actin polymerization but also couples phosphoinositide‐3 kinase signaling to Rac activation, thereby influencing dynamic actin remodeling during both normal cell migration and invasive processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, Abi1 bridges receptor‐linked and nonreceptor tyrosine kinase signaling pathways. It associates with adaptor proteins like Grb4 to link ephrin–Eph receptor signals to downstream cytoskeletal regulators, and it promotes c‐Abl–mediated tyrosine phosphorylation of targets such as Mena, thereby modulating actin filament organization."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, Abi1 can interact with formin proteins to regulate filopodia formation and contribute to cell–cell junction stability, linking actin assembly not only to cell motility but also to adhesion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Through these multifaceted roles, Abi1 serves as an integral node that translates diverse extracellular and intracellular signals into coordinated actin cytoskeletal reorganization. This function is pivotal in physiological processes—including cell migration, adhesion, and synaptic remodeling—and in pathological contexts such as cancer metastasis, microbial invasion, and neurodegeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Metello Innocenti, Adriana Zucconi, Andrea Disanza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abi1 is essential for the formation and activation of a WAVE2 signalling complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1105"}], "href": "https://doi.org/10.1038/ncb1105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15048123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15048123"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Anika Steffen, Klemens Rottner, Julia Ehinger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7600084"}], "href": "https://doi.org/10.1038/sj.emboj.7600084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14765121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14765121"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yan Leng, Jinyi Zhang, Karen Badour, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0409120102"}], "href": "https://doi.org/10.1073/pnas.0409120102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15657136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15657136"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Patrycja M Dubielecka, Kathrin I Ladwein, Xiaoling Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential role for Abi1 in embryonic survival and WAVE2 complex integrity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1016811108"}], "href": "https://doi.org/10.1073/pnas.1016811108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21482783"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21482783"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Metello Innocenti, Emanuela Frittoli, Isabella Ponzanelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200206079"}], "href": "https://doi.org/10.1083/jcb.200206079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12515821"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12515821"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Andrea Disanza, Marie-France Carlier, Theresia E B Stradal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Eps8 controls actin-based motility by capping the barbed ends of actin filaments."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1199"}], "href": "https://doi.org/10.1038/ncb1199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15558031"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15558031"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Huijun Chen, Xufeng Wu, Zhixing K Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-10-2394"}], "href": "https://doi.org/10.1158/0008-5472.CAN-10-2394"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21118970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21118970"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "C A Cowan, M Henkemeyer "}, {"type": "b", "children": [{"type": "t", "text": "The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/35093123"}], "href": "https://doi.org/10.1038/35093123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11557983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11557983"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Katsuko Tani, Seiichi Sato, Taiko Sukezane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M301447200"}], "href": "https://doi.org/10.1074/jbc.M301447200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12672821"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12672821"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Mingqun Lin, Amke den Dulk-Ras, Paul J J Hooykaas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Anaplasma phagocytophilum AnkA secreted by type IV secretion system is tyrosine phosphorylated by Abl-1 to facilitate infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Microbiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1462-5822.2007.00985.x"}], "href": "https://doi.org/10.1111/j.1462-5822.2007.00985.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17587335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17587335"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Changsong Yang, Lubov Czech, Silke Gerboth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.0050317"}], "href": "https://doi.org/10.1371/journal.pbio.0050317"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18044991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18044991"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jae Ryun Ryu, Asier Echarri, Ran Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of cell-cell adhesion by Abi/Diaphanous complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01483-08"}], "href": "https://doi.org/10.1128/MCB.01483-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19158278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19158278"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ah-Lai Law, Anne Vehlow, Maria Kotini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201304051"}], "href": "https://doi.org/10.1083/jcb.201304051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24247431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24247431"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Cristine Betzer, A James Movius, Min Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of synaptosomal proteins binding to monomeric and oligomeric α-synuclein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0116473"}], "href": "https://doi.org/10.1371/journal.pone.0116473"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25659148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25659148"}]}]}]}
Synonyms	NAP1BP, SSH3BP1, ABLBP4, E3B1, ABI-1, SSH3BP
Proteins	ABI1_HUMAN
NCBI Gene ID	10006
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ABI1 has 8,897 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 131 datasets.

Click the + buttons to view associations for ABI1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ABI1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ABI1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ABI1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ABI1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ABI1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ABI1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ABI1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ABI1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ABI1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ABI1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ABI1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ABI1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ABI1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with ABI1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ABI1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ABI1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ABI1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ABI1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of ABI1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ABI1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ABI1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ABI1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ABI1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ABI1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ABI1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ABI1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ABI1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing ABI1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ABI1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ABI1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ABI1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ABI1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ABI1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ABI1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ABI1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ABI1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ABI1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ABI1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ABI1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ABI1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ABI1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.