ACAD10 Gene

Name	acyl-CoA dehydrogenase family, member 10
Description	This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ACAD10 is a mitochondrial acyl‐CoA dehydrogenase that plays an important role in the β‐oxidation of fatty acids—particularly branched‐chain substrates—and is widely expressed in human tissues, with notable expression during fetal development in the brain."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In human genetic studies and corresponding mouse models, variation or deficiency in ACAD10 has been linked to abnormal lipid oxidation, lower rates of fatty acid utilization, impaired insulin sensitivity, and increased risk for type 2 diabetes as well as altered adipocyte morphology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, genetic polymorphisms within the ACAD10 locus have been associated with sex‐specific differences in blood pressure regulation and even with features related to neovascular age‐related macular degeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its established role in fatty acid catabolism, recent findings indicate that ACAD10 expression is upregulated through pathways modulated by metformin. In experimental models, metformin treatment leads to inhibition of mTORC1 signaling, which in turn induces ACAD10 expression. This induction is implicated in mediating metformin’s anti‐proliferative, pro‐apoptotic, and potentially anti‐aging effects, as demonstrated in both invertebrate systems and human cell contexts (e.g., in psoriasis keratinocytes)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": " Moreover, ACAD10 has been identified as a target of long non-coding RNAs involved in adipogenesis, further linking its activity to the regulation of lipid metabolism and energy homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore that ACAD10 is a multifunctional enzyme central not only to mitochondrial fatty acid β-oxidation but also to broader metabolic and cellular signaling pathways. Its modulation appears to influence critical aspects of energy metabolism, insulin sensitivity, cardiovascular regulation, and even cellular responses to metabolic stress, thereby positioning ACAD10 as a promising link between metabolic dysfunction and a range of complex diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "12"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Miao He, Zhengtong Pei, Al-Walid Mohsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of new long chain acyl-CoA dehydrogenases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2010.12.005"}], "href": "https://doi.org/10.1016/j.ymgme.2010.12.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21237683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21237683"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xin Ye, Chaoneng Ji, Chun Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cloning and characterization of a human cDNA ACAD10 mapped to chromosome 12q24.1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1023/b:mole.0000043622.57408.6b"}], "href": "https://doi.org/10.1023/b:mole.0000043622.57408.6b"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15560374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15560374"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "L Bian, R L Hanson, Y L Muller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-010-1695-y"}], "href": "https://doi.org/10.1007/s00125-010-1695-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20390405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20390405"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kaitlyn Bloom, Al-Walid Mohsen, Anuradha Karunanidhi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Investigating the link of ACAD10 deficiency to type 2 diabetes mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Inherit Metab Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10545-017-0013-y"}], "href": "https://doi.org/10.1007/s10545-017-0013-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28120165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28120165"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Joelle A Hallak, Luis de Sisternes, Aaron Osborne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Imaging, Genetic, and Demographic Factors Associated With Conversion to Neovascular Age-Related Macular Degeneration: Secondary Analysis of a Randomized Clinical Trial."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JAMA Ophthalmol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/jamaophthalmol.2019.0868"}], "href": "https://doi.org/10.1001/jamaophthalmol.2019.0868"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31021381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31021381"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Seong-Beom Cho, Jinhwa Jang "}, {"type": "b", "children": [{"type": "t", "text": "A Genome-Wide Association Study of a Korean Population Identifies Genetic Susceptibility to Hypertension Based on Sex-Specific Differences."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes12111804"}], "href": "https://doi.org/10.3390/genes12111804"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34828409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34828409"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Federico Pietrocola, Guido Kroemer "}, {"type": "b", "children": [{"type": "t", "text": "Metformin: a metabolic modulator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.14794"}], "href": "https://doi.org/10.18632/oncotarget.14794"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28122334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28122334"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jorge Iván Castillo-Quan, T Keith Blackwell "}, {"type": "b", "children": [{"type": "t", "text": "Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2016.11.058"}], "href": "https://doi.org/10.1016/j.cell.2016.11.058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27984715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27984715"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jiawen Wu, Shengxiang Xiao, Jianwen Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A unified mitochondria mechanistic target of rapamycin acyl-coenzyme A dehydrogenase 10 signal relay modulation for metformin growth inhibition in human immortalized keratinocytes cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27481"}], "href": "https://doi.org/10.1002/jcb.27481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30206977"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30206977"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jiantao Chen, Xianwei Cui, Chunmei Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential lncRNA expression profiles in brown and white adipose tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Genomics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00438-014-0954-x"}], "href": "https://doi.org/10.1007/s00438-014-0954-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25472036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25472036"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Mun-Gwan Hong, Robert Karlsson, Patrik K E Magnusson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide assessment of variability in human serum metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.22267"}], "href": "https://doi.org/10.1002/humu.22267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23281178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23281178"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kaitlyn Bloom, Anuradha Karunanidhi, Kimimasa Tobita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ACAD10 protein expression and Neurobehavioral assessment of Acad10-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0242445"}], "href": "https://doi.org/10.1371/journal.pone.0242445"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33301490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33301490"}]}]}]}
Proteins	ACD10_HUMAN
NCBI Gene ID	80724
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ACAD10 has 6,038 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 107 datasets.

Click the + buttons to view associations for ACAD10 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ACAD10 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ACAD10 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ACAD10 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ACAD10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ACAD10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ACAD10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ACAD10 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ACAD10 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ACAD10 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ACAD10 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ACAD10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ACAD10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ACAD10 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ACAD10 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ACAD10 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ACAD10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ACAD10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of ACAD10 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ACAD10 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ACAD10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ACAD10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ACAD10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ACAD10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with ACAD10 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ACAD10 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ACAD10 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ACAD10 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ACAD10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ACAD10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ACAD10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ACAD10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ACAD10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ACAD10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ACAD10 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ACAD10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ACAD10 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ACAD10 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ACAD10 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ACAD10 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ACAD10 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ACAD10 from the GeneSigDB Published Gene Signatures dataset.