ACBD3 Gene

HGNC Family	A-kinase anchor proteins (AKAP)
Name	acyl-CoA binding domain containing 3
Description	The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Acyl‐CoA binding domain containing 3 (ACBD3) is emerging as a multifunctional scaffolding protein that predominantly resides at the Golgi apparatus and plays diverse roles in both cellular physiology and viral pathogenesis. In multiple studies, ACBD3 has been shown to orchestrate the recruitment and activation of phosphatidylinositol 4‐kinase IIIβ (PI4KB) by directly binding viral proteins—most notably the picornaviral 3A proteins—to assemble complexes at designated replication organelles, which in turn enhance phosphatidylinositol 4‐phosphate (PI4P) synthesis and promote efficient viral genome replication."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": " Moreover, ACBD3 functions as a critical mediator in cellular lipid homeostasis and Golgi organization; by recruiting PI4KB to the Golgi membranes, it not only increases the enzymatic activity of PI4KB but also serves to stabilize the Golgi structure and regulate lipid signaling. Beyond these roles, ACBD3 also exerts significant influence in non-viral cellular processes—for example, by binding to the fate determinant Numb in neural progenitor cells, its cytosolic localization following Golgi fragmentation during mitosis is pivotal for proper cell-fate specification."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In the context of hepatitis C virus replication, competitive interactions involving ACBD3 modulate the engagement of PI4KB with viral factors, thereby influencing viral RNA replication."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these findings position ACBD3 as a central organizer of membrane-associated processes that not only sustains critical cellular functions—ranging from lipid metabolism and Golgi integrity to cell differentiation—but is also subverted by viruses to commandeer host lipid signaling and replication machinery."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun Sasaki, Kumiko Ishikawa, Minetaro Arita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2011.429"}], "href": "https://doi.org/10.1038/emboj.2011.429"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22124328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22124328"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Alexander L Greninger, Giselle M Knudsen, Miguel Betegon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The 3A protein from multiple picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIβ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.06778-11"}], "href": "https://doi.org/10.1128/JVI.06778-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22258260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22258260"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Martin Klima, Dániel J Tóth, Rozalie Hexnerova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep23641"}], "href": "https://doi.org/10.1038/srep23641"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27009356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27009356"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Alexander L Greninger, Giselle M Knudsen, Miguel Betegon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "mBio (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/mBio.00098-13"}], "href": "https://doi.org/10.1128/mBio.00098-13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23572552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23572552"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaobo Lei, Xia Xiao, Zhenzhen Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Golgi protein ACBD3 facilitates Enterovirus 71 replication by interacting with 3A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep44592"}], "href": "https://doi.org/10.1038/srep44592"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28303920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28303920"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yan Zhou, Joshua B Atkins, Santiago B Rompani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2007.02.037"}], "href": "https://doi.org/10.1016/j.cell.2007.02.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17418793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17418793"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zhi Hong, Xiaojie Yang, Guangbo Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatitis C virus NS5A competes with PI4KB for binding to ACBD3 in a genotype-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Antiviral Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.antiviral.2014.04.012"}], "href": "https://doi.org/10.1016/j.antiviral.2014.04.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24792752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24792752"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xihua Yue, Yi Qian, Bopil Gim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acyl-CoA-Binding Domain-Containing 3 (ACBD3; PAP7; GCP60): A Multi-Functional Membrane Domain Organizer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms20082028"}], "href": "https://doi.org/10.3390/ijms20082028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31022988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31022988"}]}]}]}
Synonyms	GCP60, GOCAP1, GOLPH1, PAP7
Proteins	GCP60_HUMAN
NCBI Gene ID	64746
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ACBD3 has 8,130 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for ACBD3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ACBD3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ACBD3 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ACBD3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ACBD3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ACBD3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ACBD3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ACBD3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ACBD3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ACBD3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ACBD3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ACBD3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ACBD3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ACBD3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ACBD3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ACBD3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ACBD3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ACBD3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ACBD3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ACBD3 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ACBD3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ACBD3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ACBD3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ACBD3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ACBD3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ACBD3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ACBD3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ACBD3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ACBD3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ACBD3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ACBD3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ACBD3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ACBD3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ACBD3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ACBD3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ACBD3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ACBD3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ACBD3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ACBD3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ACBD3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ACBD3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ACBD3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.