ACSL5 Gene

HGNC Family	Acyl-CoA synthetase family (ACS)
Name	acyl-CoA synthetase long-chain family member 5
Description	The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ACSL5, a member of the long‐chain acyl‐CoA synthetase family, has emerged as an important regulator at the crossroads of lipid metabolism and cell fate. Several studies have demonstrated that increased expression of ACSL5 can protect tumor cells from apoptosis by maintaining mitochondrial cardiolipin content and preventing cytochrome c release, thereby suppressing cell death induced by acyl‐CoA synthetase inhibition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In malignant glioma, ACSL5 activity is critical for cell survival under conditions of extracellular acidosis, acting in an enzyme‐dependent manner to modulate the expression of pro‐survival factors such as midkine."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In hepatic models, ACSL5 is transcriptionally upregulated by factors like oncostatin M, channeling long‐chain fatty acids toward β‐oxidation pathways and contributing to decreased triglyceride accumulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In the context of cancer therapeutics, a novel FGFR2–ACSL5 fusion has been identified in FGFR2‐amplified gastric cancer, implicating ACSL5 in the development of resistance to targeted FGFR inhibition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Beyond its role in tumor biology, genetic variation in ACSL5 has been associated with differential responses to caloric restriction and weight loss, indicating that this enzyme also contributes to adipocyte fatty acid metabolism and systemic energy balance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, in colorectal cancer, reduced ACSL5 expression in tumor tissue has been linked to poorer clinical outcomes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", while studies in human small intestine have revealed that alternative splicing of ACSL5 (full‐length versus a Δexon 20 variant) contributes to the regulation of apoptotic sensitivity during enterocyte turnover along the crypt–villus axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tetsuo Mashima, Tomoko Oh-hara, Shigeo Sato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Natl Cancer Inst (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jnci/dji133"}], "href": "https://doi.org/10.1093/jnci/dji133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15900046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15900046"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tetsuo Mashima, Shigeo Sato, Sachiko Okabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2009.01203.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2009.01203.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19459852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19459852"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "T Mashima, S Sato, Y Sugimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2008.355"}], "href": "https://doi.org/10.1038/onc.2008.355"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18806831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18806831"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yue Zhou, Parveen Abidi, Aekyong Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.107.148429"}], "href": "https://doi.org/10.1161/ATVBAHA.107.148429"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17761945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17761945"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sun Young Kim, Taejin Ahn, Heejin Bang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acquired resistance to LY2874455 in FGFR2-amplified gastric cancer through an emergence of novel FGFR2-ACSL5 fusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.14788"}], "href": "https://doi.org/10.18632/oncotarget.14788"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28122360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28122360"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kristi B Adamo, Robert Dent, Carl D Langefeld, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Obesity (Silver Spring) (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/oby.2007.630"}], "href": "https://doi.org/10.1038/oby.2007.630"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17495181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17495181"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Pavel Pitule, Ondrej Vycital, Jan Bruha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression and prognostic role of selected genes in colorectal cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2013)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24222123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24222123"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nikolaus Gassler, Wilfried Roth, Benjamin Funke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2007.06.005"}], "href": "https://doi.org/10.1053/j.gastro.2007.06.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17681178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17681178"}]}]}]}
Synonyms	ACS5, FACL5
Proteins	ACSL5_HUMAN
NCBI Gene ID	51703
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ACSL5 has 7,497 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 116 datasets.

Click the + buttons to view associations for ACSL5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ACSL5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ACSL5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ACSL5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ACSL5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ACSL5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ACSL5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ACSL5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ACSL5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ACSL5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ACSL5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ACSL5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ACSL5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ACSL5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ACSL5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ACSL5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ACSL5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ACSL5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ACSL5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ACSL5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ACSL5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ACSL5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ACSL5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ACSL5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ACSL5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ACSL5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ACSL5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ACSL5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ACSL5 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ACSL5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ACSL5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ACSL5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ACSL5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ACSL5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ACSL5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ACSL5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ACSL5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ACSL5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ACSL5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ACSL5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ACSL5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ACSL5 from the GeneSigDB Published Gene Signatures dataset.