{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into Lambert‑Eaton myasthenic syndrome (LEMS) have focused on the regulatory roles of long noncoding RNAs (lncRNAs) in modulating mRNA expression within autoimmune neuromuscular disorders. In this context, alterations in the lncRNA expression profile, including transcripts such as ACTG1P17, have emerged as potential contributors to disease pathology. Preliminary data suggest that these lncRNAs could influence cellular processes at the neuromuscular junction by regulating genes implicated in signal transduction and muscle function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nACTG1P17, categorized as a pseudogene of the actin gamma 1 (ACTG1) gene, may play a role in this regulatory network. Although its function is not yet fully elucidated, it is postulated that ACTG1P17 could act as a competing endogenous RNA (ceRNA) or molecular decoy, thereby modulating the stability and translation of mRNAs essential for proper neuromuscular transmission. This fine‑tuning mechanism might be critical in maintaining the delicate balance of immune and neuromuscular activities, disruptions of which are common in LEMS."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe identification of ACTG1P17 within the LEMS transcriptomic profile provides a novel insight into the complex interplay between noncoding regulatory elements and mRNA expression in autoimmune conditions. Future research into its specific mechanisms may not only clarify how its altered expression contributes to LEMS but also potentially uncover new targets for therapeutic intervention in autoimmune neuromuscular disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fei Yang, Feng Jing, Yang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma lncRNA LOC338963 and mRNA AP3B2 are upregulated in paraneoplastic Lambert-Eaton myasthenic syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Muscle Nerve (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mus.27571"}], "href": "https://doi.org/10.1002/mus.27571"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35508598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35508598"}]}]}]}