ACTN1 Gene

HGNC Family	EF-hand domain containing
Name	actinin, alpha 1
Description	Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Alpha‐actinin‑1 (ACTN1) is a non‐muscle actin‐crosslinking protein that plays a central role in organizing the cytoskeleton and tethering filamentous actin to diverse membrane complexes. ACTN1 has been shown to rapidly localize to caveolin‐enriched membrane domains in response to sphingosine‑1‑phosphate stimulation in endothelial cells, where its recruitment—along with that of its paralog ACTN4—contributes to cortical actin reorganization and barrier enhancement."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In various cancers, alternative splicing events in ACTN1 produce tumor‐specific isoforms that may alter its functional properties and thus serve as potential diagnostic or prognostic markers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, increased ACTN1 expression correlates with poorer overall survival in osteosarcoma, underscoring its importance as a prognostic indicator."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Genetic variants in ACTN1 have also been implicated in congenital macrothrombocytopenia, where mutations disrupt normal actin‐based cytoskeletal organization in megakaryocytes to yield fewer, abnormally large platelets with compromised function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n ACTN1 is further required for proper cellular motility. In studies of migrating cells, defective localization of ACTN1 in lamellipodia was associated with impaired adhesion site formation and reduced traction forces, indicating its role in coordinating actin dynamics and the formation of cell–substrate contacts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Interactions between ACTN1 and membrane receptors have been demonstrated in multiple contexts. For instance, ACTN1 directly binds the C‑terminus of the adenosine A<sub>2A</sub> receptor and is required for receptor clustering and agonist‐induced internalization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In T lymphocytes, engagement of LFA‑1 with its ligand on endothelial cells is linked to the underlying actin cytoskeleton via ACTN1, supporting sustained adhesion and promoting directed migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in adhesion, ACTN1 contributes to the stabilization of membrane channels. For example, ACTN1 associates with the C‑terminal region of the L‑type Ca<sup>2+</sup> channel Ca<sub>V</sub>1.2, thereby promoting its surface expression and ensuring proper excitation–contraction coupling in cardiac and neuronal cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Interactions with other actin‑associated proteins further broaden the functional repertoire of ACTN1. Its binding to CLP36, for example, suggests a role in segregating ACTN1 to specific actin structures during cellular shape change and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In addition, participation in a zyxin/ACTN1/p130Cas signaling module has been implicated in generating periodic oscillatory movements in three‐dimensional migratory cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In astrocytoma cells, comparative analyses of alpha‑actinin isoforms reveal that while ACTN4 predominantly modulates cell motility and adhesion, ACTN1 exhibits distinct, non‐redundant behavior, underscoring isoform‑specific functions in tumor biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Structural studies further suggest that ACTN1, like other alpha‑actinins, interacts with titin and other cytoskeletal elements through conserved binding domains, thereby linking contractile and structural networks in the cell."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In glioblastoma cells, suppression of either ACTN1 or ACTN4 leads to impaired cell motility, reduced non‑muscle myosin II expression, and diminished traction forces, emphasizing the crucial role of ACTN1 in maintaining cytoskeletal integrity and mechanosensation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, ACTN1 can be involved in oncogenic fusion events, as evidenced by the identification of a MYBL1‑ACTN1 fusion in breast adenoid cystic carcinoma, suggesting that aberrant ACTN1 function may contribute to tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Moreover, ALMS1—a protein implicated in centrosome and endosomal functions—has been found to interact with alpha‑actinin isoforms, including ACTN1, linking cytoskeletal regulation to intracellular trafficking and contributing to the pathogenesis of Alström syndrome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight the multifaceted roles of ACTN1 in cytoskeletal organization, cell adhesion, migration, and signal transduction across diverse cell types and disease contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Patrick A Singleton, Steven M Dudek, Eddie T Chiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.05-3928com"}], "href": "https://doi.org/10.1096/fj.05-3928com"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16195373"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16195373"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kasper Thorsen, Karina D Sørensen, Anne Sofie Brems-Eskildsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.M700590-MCP200"}], "href": "https://doi.org/10.1074/mcp.M700590-MCP200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18353764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18353764"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Joerg Fellenberg, Ludger Bernd, Guenter Delling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic significance of drug-regulated genes in high-grade osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/modpathol.3800937"}], "href": "https://doi.org/10.1038/modpathol.3800937"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17660802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17660802"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shinji Kunishima, Yusuke Okuno, Kenichi Yoshida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ACTN1 mutations cause congenital macrothrombocytopenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2013.01.015"}], "href": "https://doi.org/10.1016/j.ajhg.2013.01.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23434115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23434115"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kossay Zaoui, Stéphane Honoré, Daniel Isnardon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200805107"}], "href": "https://doi.org/10.1083/jcb.200805107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18955552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18955552"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Javier Burgueño, Derek J Blake, Matthew A Benson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M302809200"}], "href": "https://doi.org/10.1074/jbc.M302809200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12837758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12837758"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Paula Stanley, Andrew Smith, Alison McDowall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601959"}], "href": "https://doi.org/10.1038/sj.emboj.7601959"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18079697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18079697"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Duane D Hall, Shuiping Dai, Pang-Yen Tseng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Competition between α-actinin and Ca²⁺-calmodulin controls surface retention of the L-type Ca²⁺ channel Ca(V)1.2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2013.02.032"}], "href": "https://doi.org/10.1016/j.neuron.2013.02.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23664615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23664615"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "K Bauer, M Kratzer, M Otte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human CLP36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2000)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11110697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11110697"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Stephanie I Fraley, Yunfeng Feng, Anjil Giri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms1711"}], "href": "https://doi.org/10.1038/ncomms1711"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22395610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22395610"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Quincy Quick, Omar Skalli "}, {"type": "b", "children": [{"type": "t", "text": "Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2010.02.011"}], "href": "https://doi.org/10.1016/j.yexcr.2010.02.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20156433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20156433"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Siegfried Labeit, Sunshine Lahmers, Christoph Burkart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of distinct classes of titin isoforms in striated and smooth muscles by alternative splicing, and their conserved interaction with filamins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2006.07.077"}], "href": "https://doi.org/10.1016/j.jmb.2006.07.077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16949617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16949617"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Shamik Sen, Meimei Dong, Sanjay Kumar "}, {"type": "b", "children": [{"type": "t", "text": "Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0008427"}], "href": "https://doi.org/10.1371/journal.pone.0008427"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20037648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20037648"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jisun Kim, Felipe C Geyer, Luciano G Martelotto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.5006"}], "href": "https://doi.org/10.1002/path.5006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29149504"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29149504"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Gayle B Collin, Jan D Marshall, Benjamin L King, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0037925"}], "href": "https://doi.org/10.1371/journal.pone.0037925"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22693585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22693585"}]}]}]}
Synonyms	BDPLT15
Proteins	ACTN1_HUMAN
NCBI Gene ID	87
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ACTN1 has 15,195 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 147 datasets.

Click the + buttons to view associations for ACTN1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ACTN1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ACTN1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ACTN1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ACTN1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ACTN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ACTN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ACTN1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving ACTN1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ACTN1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ACTN1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ACTN1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ACTN1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ACTN1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ACTN1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ACTN1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ACTN1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ACTN1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ACTN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ACTN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with ACTN1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with ACTN1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ACTN1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ACTN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ACTN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ACTN1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ACTN1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ACTN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ACTN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing ACTN1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ACTN1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ACTN1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ACTN1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ACTN1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ACTN1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ACTN1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ACTN1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DEPOD Substrates of Phosphatases	phosphatases that dephosphorylate ACTN1 protein from the curated DEPOD Substrates of Phosphatases dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ACTN1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ACTN1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ACTN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ACTN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.