ADAM23 Gene

HGNC Family	Metzincin metallopeptidases
Name	ADAM metallopeptidase domain 23
Description	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ADAM23 is a multifunctional, non‐proteolytic transmembrane protein that plays critical roles in both the central nervous system and in cancer. In neurons, ADAM23 acts as a key receptor for secreted LGI proteins, thereby mediating trans‐synaptic interactions that regulate synaptic transmission, dendritic pruning, and maturation of excitatory circuits; disruption of the LGI1–ADAM23 interaction is implicated in autoimmune encephalopathies and familial epilepsy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In addition, ADAM23 is essential for neuronal differentiation and survival, as evidenced by studies showing that its upregulation enhances neurite outgrowth and protects against apoptosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and its extracellular domains serve as specific ligands for integrin receptors (e.g. integrin α4), thereby contributing to cell‐adhesive processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In the context of cancer, aberrant epigenetic silencing of ADAM23 via promoter hypermethylation has been documented in colorectal and breast tumors, where its loss correlates with enhanced cellular invasion, altered integrin activation, and poor clinical outcome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meizan Lai, Maartje G M Huijbers, Eric Lancaster, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lancet Neurol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S1474-4422(10)70137-X"}], "href": "https://doi.org/10.1016/S1474-4422(10"}, {"type": "t", "text": "70137-X) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20580615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20580615"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Toshika Ohkawa, Yuko Fukata, Miwako Yamasaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.3506-13.2013"}], "href": "https://doi.org/10.1523/JNEUROSCI.3506-13.2013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24227725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24227725"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Emanuela Dazzo, Emanuela Leonardi, Elisa Belluzzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 Receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1006376"}], "href": "https://doi.org/10.1371/journal.pgen.1006376"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27760137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27760137"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Annett Markus-Koch, Oliver Schmitt, Susanne Seemann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAM23 promotes neuronal differentiation of human neural progenitor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-017-0045-1"}], "href": "https://doi.org/10.1186/s11658-017-0045-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28828010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28828010"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lei Wang, Jason A Hoggard, Erica D Korleski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple non-catalytic ADAMs are novel integrin α4 ligands."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-017-3190-y"}], "href": "https://doi.org/10.1007/s11010-017-3190-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28913673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28913673"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jin-Sung Choi, Kyung-Hee Kim, You-Kyung Jeon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promoter hypermethylation of the ADAM23 gene in colorectal cancer cell lines and cancer tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.24023"}], "href": "https://doi.org/10.1002/ijc.24023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19089928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19089928"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ivana Fridrichova, Bozena Smolkova, Viera Kajabova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCL12 and ADAM23 hypermethylation are associated with advanced breast cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.trsl.2014.12.006"}], "href": "https://doi.org/10.1016/j.trsl.2014.12.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25620615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25620615"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "E T Costa, G F Barnabé, M Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2014.70"}], "href": "https://doi.org/10.1038/onc.2014.70"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24662834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24662834"}]}]}]}
Synonyms	MDC-3, MDC3
Proteins	ADA23_HUMAN
NCBI Gene ID	8745
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ADAM23 has 5,597 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 116 datasets.

Click the + buttons to view associations for ADAM23 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ADAM23 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ADAM23 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAM23 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAM23 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ADAM23 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ADAM23 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ADAM23 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAM23 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAM23 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAM23 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAM23 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ADAM23 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADAM23 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAM23 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ADAM23 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAM23 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ADAM23 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ADAM23 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ADAM23 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ADAM23 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ADAM23 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ADAM23 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ADAM23 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ADAM23 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ADAM23 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing ADAM23 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ADAM23 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ADAM23 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ADAM23 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ADAM23 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ADAM23 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ADAM23 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ADAM23 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ADAM23 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ADAM23 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ADAM23 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAM23 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ADAM23 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ADAM23 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ADAM23 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with ADAM23 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.