| HGNC Family | Metzincin metallopeptidases |
| Name | ADAM metallopeptidase domain 3A (pseudogene) |
| Description | Predicted to be involved in fertilization and flagellated sperm motility. Predicted to act upstream of or within binding activity of sperm to zona pellucida; gene expression; and regulation of macromolecule metabolic process. Predicted to be located in membrane raft; plasma membrane; and sperm head. Predicted to be part of protein-containing complex. Predicted to be active in cell surface. Implicated in brain glioma and conjunctival squamous cell carcinoma. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSeveral studies have identified genomic alterations involving the ADAM3A locus in different disease contexts. In pediatric high‐grade gliomas, for example, high‐resolution copy number analysis revealed a novel homozygous deletion at 8p12 that encompasses ADAM3A, suggesting that loss of this gene may be part of distinct tumor‐specific genetic profiles in children compared with adults. In parallel, investigations of other ADAM family members (such as ADAM33 in keloid scars) and surveys of chromosomal deletions in congenital anomalies have underscored the importance of regional ADAM gene alterations, although they did not directly address ADAM3A function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancers of the head and neck, ADAM3A also appears to contribute to disease risk through copy number variation. In oropharyngeal squamous cell carcinoma, individuals harboring an increased number of copies of ADAM3A (in conjunction with the related ADAM5 pseudogene) were found to have a significantly elevated risk of disease. Mechanistically, the extra copies seem to participate in a pseudogene–microRNA–mRNA interaction network—whereby the ADAM5 pseudogene’s transcript may bind miR-122b-5p and, in turn, relieve the inhibition on ADAM9 expression—thereby potentially modulating tumor progression and overall prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther emphasizing the potential clinical relevance of ADAM3A, studies in ocular surface neoplasms have demonstrated that copy number gains and consequent overexpression of ADAM3A occur predominantly in high-grade lesions of conjunctival squamous cell carcinoma. This alteration was absent in non-neoplastic tissues and lower-grade precursor lesions, suggesting that ADAM3A gene dosage may serve as a specific biomarker for invasive disease in the ocular region."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jennifer Barrow, Martyna Adamowicz-Brice, Maria Cartmill, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuro Oncol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/neuonc/noq158"}], "href": "https://doi.org/10.1093/neuonc/noq158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21138945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21138945"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jianyu Han, Jianfeng Han, Dongmei Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of ADAM33 gene polymorphisms with keloid scars in a northeastern Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000366314"}], "href": "https://doi.org/10.1159/000366314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25201121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25201121"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Laura Asnaghi, Hind Alkatan, Alka Mahale, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of multiple DNA copy number alterations including frequent 8p11.22 amplification in conjunctival squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.14-14920"}], "href": "https://doi.org/10.1167/iovs.14-14920"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25491297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25491297"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Samuel G Younkin, Robert B Scharpf, Holger Schwender, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide study of inherited deletions identified two regions associated with nonsyndromic isolated oral clefts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Birth Defects Res A Clin Mol Teratol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/bdra.23362"}], "href": "https://doi.org/10.1002/bdra.23362"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25776870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25776870"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Juliana Carron, Caroline Torricelli, Janet Keller Silva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of Inherited Copy Number Variation in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "ADAM3A"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "ADAM5"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Pseudogenes with Oropharynx Cancer Risk and Outcome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes13122408"}], "href": "https://doi.org/10.3390/genes13122408"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36553675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36553675"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "M Adelita Vizcaino, Abeer Z Tabbarah, Laura Asnaghi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAM3A copy number gains occur in a subset of conjunctival squamous cell carcinoma and its high grade precursors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2019.08.020"}], "href": "https://doi.org/10.1016/j.humpath.2019.08.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31493427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31493427"}]}]}]}
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| Synonyms | CYRN1, TMDCI, ADAM3 |
| NCBI Gene ID | 1587 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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ADAM3A has 963 functional associations with biological entities spanning 7 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 36 datasets.
Click the + buttons to view associations for ADAM3A from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of ADAM3A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of ADAM3A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ADAM3A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ADAM3A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of ADAM3A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of ADAM3A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAM3A gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of ADAM3A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ADAM3A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| CTD Gene-Disease Associations | diseases associated with ADAM3A gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with ADAM3A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ADAM3A gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAM3A gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of ADAM3A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of ADAM3A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with ADAM3A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing ADAM3A from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of ADAM3A gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ADAM3A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of ADAM3A gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ADAM3A gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of ADAM3A gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of ADAM3A gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of ADAM3A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of ADAM3A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of ADAM3A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of ADAM3A gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of ADAM3A gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by ADAM3A gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of ADAM3A gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of ADAM3A gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of ADAM3A gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ADAM3A gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of ADAM3A gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of ADAM3A protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with ADAM3A protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
