ADAM8 Gene

HGNC Family	CD molecules (CD), Metzincin metallopeptidases
Name	ADAM metallopeptidase domain 8
Description	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ADAM8 is a membrane‐anchored disintegrin and metalloprotease that contributes to the regulation of cell–cell interactions and signaling via ectodomain shedding. In several studies its proteolytic activity was shown to mediate cleavage of key substrates such as the low‐affinity IgE receptor CD23, thereby implicating ADAM8 in the modulation of immune responses and allergic inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In experimental models of asthma, ADAM8 expression is strongly induced by allergens and TH2 cytokines, and its upregulation in both hematopoietic and nonhematopoietic compartments correlates with airway remodeling and enhanced inflammatory cell recruitment; loss or selective deficiency of ADAM8 significantly attenuates airway inflammation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of cancer, elevated ADAM8 expression has been associated with enhanced tumor cell migration, invasiveness, and metastasis. For example, high ADAM8 levels in lung and pancreatic cancers correlate with advanced disease stage and reduced patient survival, and experimental inhibition of ADAM8 decreases extracellular signal activation and invasiveness."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n ADAM8 also plays important roles in the nervous system. Its capacity to cleave the neural cell adhesion molecule CHL1 leads to the release of soluble fragments that stimulate neurite outgrowth and promote cell survival, while in models of motor neuron degeneration, ADAM8‐mediated cleavage of TNF receptor 1 appears to confer neuroprotection by modulating inflammatory signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although ADAM8 is expressed during embryonic development—with localization in trophoblast derivatives and other tissues—genetic deletion of Adam8 in mice does not result in overt developmental defects, suggesting its functions become especially critical under pathological conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, ADAM8 expression in activated neutrophils and other myeloid cells under inflammatory conditions may enhance shedding of adhesion molecules and thereby facilitate leukocyte migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Collectively, these findings emphasize that ADAM8 is a multifunctional protease that modulates inflammatory processes, tumor progression, and neural cell functions, making it a promising target for therapeutic intervention in a range of diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anne M Fourie, Fawn Coles, Veronica Moreno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M213157200"}], "href": "https://doi.org/10.1074/jbc.M213157200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12777399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12777399"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Uwe Schlomann, Dirk Wildeboer, Ailsa Webster, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M203355200"}], "href": "https://doi.org/10.1074/jbc.M203355200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12372841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12372841"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marina Miller, Peter Rosenthal, Andrew Beppu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1303047"}], "href": "https://doi.org/10.4049/jimmunol.1303047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24623133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24623133"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Susan C Foley, Andrea K Mogas, Ron Olivenstein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased expression of ADAM33 and ADAM8 with disease progression in asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2006.12.665"}], "href": "https://doi.org/10.1016/j.jaci.2006.12.665"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17339047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17339047"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nina E King, Nives Zimmermann, Samuel M Pope, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2004-0026OC"}], "href": "https://doi.org/10.1165/rcmb.2004-0026OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15087305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15087305"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Silvia Naus, Marie-Renée Blanchet, Klaus Gossens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Crit Care Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1164/rccm.200909-1396OC"}], "href": "https://doi.org/10.1164/rccm.200909-1396OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20194813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20194813"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nobuhisa Ishikawa, Yataro Daigo, Wataru Yasui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAM8 as a novel serological and histochemical marker for lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-04-1436"}], "href": "https://doi.org/10.1158/1078-0432.CCR-04-1436"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15623614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15623614"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "N Valkovskaya, H Kayed, K Felix, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1582-4934.2007.00082.x"}], "href": "https://doi.org/10.1111/j.1582-4934.2007.00082.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17979891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17979891"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Fangyong Dong, Michael Eibach, Jörg W Bartsch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuro Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/neuonc/nov042"}], "href": "https://doi.org/10.1093/neuonc/nov042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25825051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25825051"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Silvia Naus, Melanie Richter, Dirk Wildeboer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M400560200"}], "href": "https://doi.org/10.1074/jbc.M400560200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14761956"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14761956"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jörg W Bartsch, Dirk Wildeboer, Garrit Koller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor necrosis factor-alpha (TNF-alpha) regulates shedding of TNF-alpha receptor 1 by the metalloprotease-disintegrin ADAM8: evidence for a protease-regulated feedback loop in neuroprotection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1520-10.2010"}], "href": "https://doi.org/10.1523/JNEUROSCI.1520-10.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20826683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20826683"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kristine Kelly, Gillian Hutchinson, Daniela Nebenius-Oosthuizen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.20221"}], "href": "https://doi.org/10.1002/dvdy.20221"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15580619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15580619"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Maria Gómez-Gaviro, Maria Domínguez-Luis, Javier Canchado, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.178.12.8053"}], "href": "https://doi.org/10.4049/jimmunol.178.12.8053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17548643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17548643"}]}]}]}
Synonyms	MS2, CD156, CD156A
Proteins	ADAM8_HUMAN
NCBI Gene ID	101
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ADAM8 has 5,937 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 109 datasets.

Click the + buttons to view associations for ADAM8 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ADAM8 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAM8 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ADAM8 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ADAM8 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ADAM8 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAM8 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAM8 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAM8 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAM8 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADAM8 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAM8 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ADAM8 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAM8 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ADAM8 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ADAM8 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ADAM8 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ADAM8 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ADAM8 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ADAM8 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ADAM8 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing ADAM8 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADAM8 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with ADAM8 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ADAM8 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ADAM8 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ADAM8 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ADAM8 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ADAM8 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ADAM8 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAM8 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ADAM8 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ADAM8 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ADAM8 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with ADAM8 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAM8 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ADAM8 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ADAM8 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of ADAM8 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of ADAM8 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of ADAM8 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ADAM8 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.