Name | ADAM-like, decysin 1 |
Description | This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ADAM‐like Decysin‐1 (ADAMDEC1) is an atypical, secreted metalloprotease with unique biochemical features—including an unusual zinc‐binding active site that employs an aspartic acid residue instead of a histidine—which enable it to evade inhibition by conventional metalloprotease inhibitors (e.g. TIMP‐3)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Originally identified as a novel member of the ADAM family with a truncated domain structure compared with classical ADAM proteins, ADAMDEC1 is expressed predominantly by cells of the innate immune system (such as dendritic cells and macrophages) and can be regulated by inflammatory signaling pathways including MAP kinases and NFκB."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In inflammatory and immune-mediated diseases, ADAMDEC1 expression is dynamically modulated. For example, its marked upregulation in lung tissues correlates with disease severity and may contribute to lung damage and remodeling in sarcoidosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while in the gastrointestinal tract, ADAMDEC1 has been implicated in maintaining colon epithelial integrity during colitis and protecting against bacterial insults in Crohn’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Furthermore, in conditions such as rosacea, elevated ADAMDEC1 levels in M1‐polarized macrophages potentiate local inflammation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and its upregulation is also observed in monocytes from patients with systemic lupus erythematosus, underscoring a role in modulating immune cell activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its functions in immune regulation and tissue remodeling, ADAMDEC1 plays context‐dependent roles in cancer. In certain malignancies such as glioblastoma and non‐small cell lung cancer, ADAMDEC1 is upregulated and contributes to oncogenic signaling—either by establishing a positive feedback loop that releases and activates FGF2 to maintain cancer stem cell properties"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "or by engaging the PI3K/AKT pathway to promote proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In contrast, in epithelial contexts ADAMDEC1 secreted by normal cells can facilitate the apical extrusion of neighboring transformed cells by modulating cytoskeletal regulators such as filamin, thereby contributing to an intrinsic anticancer mechanism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, ADAMDEC1 expression is altered during tumorigenesis in colorectal cancer and adenoma, where decreased expression is observed during tumor progression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", and its differential regulation has been noted in unstable atherosclerotic plaques, suggesting a possible contribution to extracellular matrix reorganization and plaque destabilization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Furthermore, emerging roles in placental development have been indicated by findings that ADAMDEC1 promotes trophoblast differentiation, with potential implications for preeclampsia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, ADAMDEC1 functions as a multifaceted mediator at the interface of innate immunity, tissue remodeling, and cancer biology. Its proteolytic activity, regulated expression in immune cells and responsiveness to inflammatory stimuli enable it to act both as a modulator of immune responses and as a facilitator of cellular processes such as growth factor activation and extracellular remodeling. Thus, ADAMDEC1 represents a promising candidate as a biomarker and therapeutic target in diverse pathological conditions ranging from inflammatory diseases and autoimmunity to cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}, {"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jacob Lund, Linda Troeberg, Henrik Kjeldal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.601724"}], "href": "https://doi.org/10.1074/jbc.M114.601724"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25564618"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25564618"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Elizabeth E M Bates, Wolf H Fridman, Chris G F Mueller "}, {"type": "b", "children": [{"type": "t", "text": "The ADAMDEC1 (decysin) gene structure: evolution by duplication in a metalloprotease gene cluster on chromosome 8p12."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunogenetics (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00251-002-0430-3"}], "href": "https://doi.org/10.1007/s00251-002-0430-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12037602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12037602"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lihua Shi, Song Li, Kelly Maurer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhancer RNA and NFκB-dependent P300 regulation of ADAMDEC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2018.09.019"}], "href": "https://doi.org/10.1016/j.molimm.2018.09.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30352365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30352365"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Elliott D Crouser, Daniel A Culver, Kenneth S Knox, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Crit Care Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1164/rccm.200803-490OC"}], "href": "https://doi.org/10.1164/rccm.200803-490OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19218196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19218196"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Guadalupe J Jasso, Alok Jaiswal, Mukund Varma, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Discov (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/2159-8290.CD-18-1308"}], "href": "https://doi.org/10.1158/2159-8290.CD-18-1308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31434712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31434712"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Weiliang Zhu, Lin Shi, Yuxin Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of ADAMDEC1 correlates with tumor progression and predicts poor prognosis in non-small cell lung cancer (NSCLC) via the PI3K/AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.14354"}], "href": "https://doi.org/10.1111/1759-7714.14354"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35178875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35178875"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xueliang Liu, Hao Huang, Xuehan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of ADAMDEC1 inhibits the progression of glioma in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-18-227"}], "href": "https://doi.org/10.14670/HH-18-227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32378728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32378728"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yuta Yako, Takashi Hayashi, Yasuto Takeuchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAM-like Decysin-1 (ADAMDEC1) is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-27469-z"}], "href": "https://doi.org/10.1038/s41598-018-27469-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29941981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29941981"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Donia P Macartney-Coxson, Kylie A Hood, Hong-jun Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-8-187"}], "href": "https://doi.org/10.1186/1471-2407-8-187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18590575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18590575"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Orsolya Galamb, Balázs Györffy, Ferenc Sipos, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Monocyte subsets exhibit transcriptional plasticity and a shared response to interferon in SIV-infected rhesus macaques."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/JLB.4A0217-047R"}], "href": "https://doi.org/10.1002/JLB.4A0217-047R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29345061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29345061"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Zhuo-Hang Li, Xia Li, Fang-Fang Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Molecular landscape of T cell-mediated rejection in human kidney transplants: prominence of CTLA4 and PD ligands."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Transplant (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/ajt.12946"}], "href": "https://doi.org/10.1111/ajt.12946"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25219326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25219326"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Mario Berger, Henriette Moscatelli, Bettina Kulle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thromb Haemost (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1160/TH08-01-0059"}], "href": "https://doi.org/10.1160/TH08-01-0059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18449420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18449420"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Britta Stoermann, Karsten Kretschmer, Sandra Düber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "B-1a cells are imprinted by the microenvironment in spleen and peritoneum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200636640"}], "href": "https://doi.org/10.1002/eji.200636640"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17492803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17492803"}]}]}]}
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Synonyms | M12.219 |
Proteins | ADEC1_HUMAN |
NCBI Gene ID | 27299 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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ADAMDEC1 has 4,291 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 87 datasets.
Click the + buttons to view associations for ADAMDEC1 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
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Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by ADAMDEC1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ADAMDEC1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of ADAMDEC1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of ADAMDEC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ADAMDEC1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of ADAMDEC1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ADAMDEC1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ADAMDEC1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of ADAMDEC1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of ADAMDEC1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with ADAMDEC1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAMDEC1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of ADAMDEC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of ADAMDEC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ADAMDEC1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing ADAMDEC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing ADAMDEC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with ADAMDEC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with ADAMDEC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of ADAMDEC1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with ADAMDEC1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Disease Associations | diseases associated with ADAMDEC1 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by ADAMDEC1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with ADAMDEC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with ADAMDEC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with ADAMDEC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with ADAMDEC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ADAMDEC1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAMDEC1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of ADAMDEC1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing ADAMDEC1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with ADAMDEC1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with ADAMDEC1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of ADAMDEC1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with ADAMDEC1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing ADAMDEC1 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of ADAMDEC1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ADAMDEC1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of ADAMDEC1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ADAMDEC1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of ADAMDEC1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GlyGen Glycosylated Proteins | ligands (chemical) binding ADAMDEC1 protein from the GlyGen Glycosylated Proteins dataset. | |
GO Biological Process Annotations 2015 | biological processes involving ADAMDEC1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving ADAMDEC1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving ADAMDEC1 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing ADAMDEC1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing ADAMDEC1 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing ADAMDEC1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by ADAMDEC1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by ADAMDEC1 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by ADAMDEC1 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of ADAMDEC1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of ADAMDEC1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ADAMDEC1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of ADAMDEC1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of ADAMDEC1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of ADAMDEC1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ADAMDEC1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with ADAMDEC1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for ADAMDEC1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of ADAMDEC1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of ADAMDEC1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of ADAMDEC1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of ADAMDEC1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of ADAMDEC1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ADAMDEC1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing ADAMDEC1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain ADAMDEC1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by ADAMDEC1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of ADAMDEC1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of ADAMDEC1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ADAMDEC1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of ADAMDEC1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving ADAMDEC1 protein from the Wikipathways PFOCR 2024 dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ADAMDEC1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of ADAMDEC1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of ADAMDEC1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of ADAMDEC1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of ADAMDEC1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of ADAMDEC1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of ADAMDEC1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of ADAMDEC1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ADAMDEC1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of ADAMDEC1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ADAMDEC1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with ADAMDEC1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with ADAMDEC1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |