ADAMTS14 Gene

HGNC Family	Metzincin metallopeptidases
Name	ADAM metallopeptidase with thrombospondin type 1 motif, 14
Description	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ADAMTS14 is a secreted metalloproteinase belonging to the ADAMTS family that plays multifaceted roles in extracellular matrix (ECM) organization and remodeling. Several studies have implicated ADAMTS14 in the maturation of collagen fibers and procollagen processing, with genetic variants and altered expression associated with osteoarthritis and fibrotic conditions such as Dupuytren’s disease, suggesting that subtle changes in its activity may affect collagen biosynthesis and ECM integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In connective tissues, ADAMTS14 has been shown to function as a procollagen N‐propeptidase and its genetic variants correlate with musculoskeletal phenotypes, for instance in Achilles tendon pathology and hypertrophic scarring, hinting at its involvement in tissue remodeling and repair."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In preclinical models, knockout studies indicate that although ADAMTS14 alone may not markedly perturb aminoprocollagen processing, its combined loss with related proteases can lead to aberrant immune activation and cutaneous lesions, suggesting an unexpected role in modulating immune–mesenchymal cross-talk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Dysregulation of ADAMTS14 has also been linked to cancer progression. In hepatocellular and colorectal carcinomas, altered ADAMTS14 expression—as well as its regulation by microRNAs such as miR‑30a—correlates with tumor stage, size, and poor prognosis, highlighting its potential as a biomarker in the oncogenic process."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, ADAMTS14 can proteolytically process substrates such as LOXL1, thereby potentially influencing ECM cross‐linking, while its capacity to activate pro–VEGFC suggests a contributory role in adult lymphangiogenesis and vascular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, variations in ADAMTS14 expression have been observed in developmental pathologies, including altered expression in amniotic fluid mesenchymal cells from neural tube defect fetuses, further emphasizing its importance in ECM deposition during tissue development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Collectively, these findings indicate that ADAMTS14 serves as an important modulator of ECM composition by influencing collagen maturation, matrix remodeling, and growth factor activation, and that its dysregulation is associated with a spectrum of pathologies—from degenerative joint disease and fibrotic disorders to cancer progression and lymphatic dysfunction—making it a promising target for future therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_fs", "start_ref": "4", "end_ref": "6"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "J Rodriguez-Lopez, M Pombo-Suarez, J Loughlin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Osteoarthritis Cartilage (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.joca.2008.07.012"}], "href": "https://doi.org/10.1016/j.joca.2008.07.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18790654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18790654"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Carine Le Goff, Robert P T Somerville, Frederic Kesteloot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.02308"}], "href": "https://doi.org/10.1242/dev.02308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16556917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16556917"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Phillip Johnston, Adrian J Chojnowski, Rose K Davidson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A complete expression profile of matrix-degrading metalloproteinases in Dupuytren's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hand Surg Am (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jhsa.2006.12.010"}], "href": "https://doi.org/10.1016/j.jhsa.2006.12.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17336841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17336841"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Louis El Khoury, Michael Posthumus, Malcolm Collins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: a genetic association study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Sci Med Sport (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsams.2013.02.006"}], "href": "https://doi.org/10.1016/j.jsams.2013.02.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23491141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23491141"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "L Dupont, G Ehx, M Chantry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Matrix Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.matbio.2018.04.002"}], "href": "https://doi.org/10.1016/j.matbio.2018.04.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29649548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29649548"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ming-Jen Sheu, Ming-Ju Hsieh, Ying-Erh Chou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of ADAMTS14 genetic polymorphism and cigarette smoking on the clinicopathologic development of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0172506"}], "href": "https://doi.org/10.1371/journal.pone.0172506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28231306"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28231306"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "He-Ming Wang, Lai-Lin Fu, Yan-Xin Cui "}, {"type": "b", "children": [{"type": "t", "text": "miR-30a Serves as a Tumor Suppressor for Hepatocellular Carcinoma by Downregulating ADAMTS14."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Lab (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7754/Clin.Lab.2021.210819"}], "href": "https://doi.org/10.7754/Clin.Lab.2021.210819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35536085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35536085"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tamara Rosell-García, Sergio Rivas-Muñoz, Alain Colige, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cleavage of LOXL1 by BMP1 and ADAMTS14 Proteases Suggests a Role for Proteolytic Processing in the Regulation of LOXL1 Function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms23063285"}], "href": "https://doi.org/10.3390/ijms23063285"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35328709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35328709"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Laura Dupont, Loïc Joannes, Florent Morfoisse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAMTS2 and ADAMTS14 can substitute for ADAMTS3 in adults for pro-VEGFC activation and lymphatic homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.151509"}], "href": "https://doi.org/10.1172/jci.insight.151509"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35316211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35316211"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Nynke A Hosper, Ruud A Bank, Paul P van den Berg "}, {"type": "b", "children": [{"type": "t", "text": "Human amniotic fluid-derived mesenchymal cells from fetuses with a neural tube defect do not deposit collagen type i protein after TGF-β1 stimulation in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Dev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/scd.2013.0334"}], "href": "https://doi.org/10.1089/scd.2013.0334"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24171700"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24171700"}]}]}]}
Proteins	ATS14_HUMAN
NCBI Gene ID	140766
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ADAMTS14 has 4,213 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 105 datasets.

Click the + buttons to view associations for ADAMTS14 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ADAMTS14 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAMTS14 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAMTS14 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ADAMTS14 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ADAMTS14 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ADAMTS14 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAMTS14 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAMTS14 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAMTS14 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADAMTS14 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAMTS14 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ADAMTS14 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAMTS14 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ADAMTS14 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ADAMTS14 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ADAMTS14 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ADAMTS14 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ADAMTS14 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ADAMTS14 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ADAMTS14 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADAMTS14 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ADAMTS14 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ADAMTS14 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ADAMTS14 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ADAMTS14 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ADAMTS14 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ADAMTS14 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ADAMTS14 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ADAMTS14 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ADAMTS14 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ADAMTS14 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ADAMTS14 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ADAMTS14 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAMTS14 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ADAMTS14 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ADAMTS14 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ADAMTS14 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with ADAMTS14 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ADAMTS14 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ADAMTS14 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of ADAMTS14 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.