ADAMTS18 Gene

HGNC Family	Metzincin metallopeptidases
Name	ADAM metallopeptidase with thrombospondin type 1 motif, 18
Description	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients. [provided by RefSeq, May 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ADAMTS18 is a secreted metalloproteinase that plays diverse roles in extracellular matrix remodeling and tissue development. Genetic studies have implicated ADAMTS18 in the regulation of bone mineral density and osteogenesis, suggesting that this protease contributes to skeletal integrity and osteoporosis risk."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n In addition, multiple independent studies have demonstrated that ADAMTS18 functions as a tumor suppressor. Its expression is frequently downregulated or silenced by promoter hypermethylation in various carcinomas—including breast, lung, colorectal, gastric, and renal cancers—where loss of ADAMTS18 correlates with enhanced cell proliferation, migration, epithelial–mesenchymal transition, metastasis, and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "10"}]}, {"type": "t", "text": " \n Moreover, ADAMTS18 is critical in ocular development; mutations in this gene underlie a spectrum of eye disorders, including Knobloch syndrome, microcornea, ectopia lentis, cone–rod dystrophy, and retinal dystrophies, highlighting its importance in normal eye morphogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n ADAMTS18 also modulates endothelial cell function and angiogenesis, as evidenced by its regulation of cell proliferation and tube formation; post‐translational processing—such as thrombin cleavage generating a shorter isoform—further influences its functional activity in hemostasis and possibly platelet fragmentation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "16"}]}, {"type": "t", "text": " \n Additionally, studies in developmental models have revealed that ADAMTS18 contributes to the morphogenesis of branched organs, being expressed in ureteric epithelial progenitors and regulating branching in the kidney and lacrimal gland, processes that are critical for proper organ formation and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings illustrate that ADAMTS18 is a multifunctional enzyme with pivotal roles in tissue homeostasis, tumor suppression, ocular and organ development, and vascular regulation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dong-Hai Xiong, Xiao-Gang Liu, Yan-Fang Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2009.01.025"}], "href": "https://doi.org/10.1016/j.ajhg.2009.01.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19249006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19249006"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daniel L Koller, Shoji Ichikawa, Dongbing Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2009-1903"}], "href": "https://doi.org/10.1210/jc.2009-1903"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20164292"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20164292"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianlu Wei, Chuan-ju Liu, Zongdong Li "}, {"type": "b", "children": [{"type": "t", "text": "ADAMTS-18: a metalloproteinase with multiple functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Biosci (Landmark Ed) (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2741/4296"}], "href": "https://doi.org/10.2741/4296"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24896365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24896365"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "H Jin, X Wang, J Ying, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1210559"}], "href": "https://doi.org/10.1038/sj.onc.1210559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17546048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17546048"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Cristina G Viloria, Alvaro J Obaya, Angela Moncada-Pazos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-4155"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-4155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19458070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19458070"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhi Li, Wei Zhang, Yong Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High-resolution melting analysis of ADAMTS18 methylation levels in gastric, colorectal and pancreatic cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-009-9323-8"}], "href": "https://doi.org/10.1007/s12032-009-9323-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19806480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19806480"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hongying Xu, Qian Xiao, Yu Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic silencing of ADAMTS18 promotes cell migration and invasion of breast cancer through AKT and NF-κB signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.1076"}], "href": "https://doi.org/10.1002/cam4.1076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28503860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28503860"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yan Zhang, Hongying Xu, Junhao Mu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inactivation of ADAMTS18 by aberrant promoter hypermethylation contribute to lung cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27439"}], "href": "https://doi.org/10.1002/jcp.27439"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30417422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30417422"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ben Xu, Yi-Ji Peng, Bing-Lei Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant methylation of the 16q23.1 tumor suppressor gene ADAMTS18 promotes tumorigenesis and progression of clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Genomics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13258-021-01036-9"}], "href": "https://doi.org/10.1007/s13258-021-01036-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33469885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33469885"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Lin Zhang, Yibin Liu, Pengtao Zheng "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of ADAMTS18 May Serve as a Poor Prognostic Biomarker for Cervical Cancer Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Appl Immunohistochem Mol Morphol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAI.0000000000000496"}], "href": "https://doi.org/10.1097/PAI.0000000000000496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28362704"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28362704"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Mohammed A Aldahmesh, Arif O Khan, Jawahir Y Mohamed, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of ADAMTS18 as a gene mutated in Knobloch syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2011-100306"}], "href": "https://doi.org/10.1136/jmedgenet-2011-100306"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21862674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21862674"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ivana Peluso, Ivan Conte, Francesco Testa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ADAMTS18 gene is responsible for autosomal recessive early onset severe retinal dystrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Orphanet J Rare Dis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1750-1172-8-16"}], "href": "https://doi.org/10.1186/1750-1172-8-16"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23356391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23356391"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Aman Chandra, Gavin Arno, Kathleen Williamson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expansion of ocular phenotypic features associated with mutations in ADAMTS18."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JAMA Ophthalmol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/jamaophthalmol.2014.940"}], "href": "https://doi.org/10.1001/jamaophthalmol.2014.940"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24874986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24874986"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Isidore Mushimiyimana, Henri Niskanen, Mustafa Beter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkab633"}], "href": "https://doi.org/10.1093/nar/gkab633"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34320216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34320216"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jianhui Wang, Wei Zhang, Zanhua Yi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a thrombin cleavage site and a short form of ADAMTS-18."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2012.02.081"}], "href": "https://doi.org/10.1016/j.bbrc.2012.02.081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22386991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22386991"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Suying Dang, Dawei Bu, Tiantian Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adamts18 deficiency increases arterial thrombus formation associated with vascular defects in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.02.032"}], "href": "https://doi.org/10.1016/j.bbrc.2018.02.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29421655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29421655"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Elisabeth A Rutledge, Nils O Lindström, Odysse Michos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2019.11.007"}], "href": "https://doi.org/10.1016/j.ydbio.2019.11.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31734175"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31734175"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Liya Wang, Min Sun, Qi Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAMTS18 regulates early branching morphogenesis of lacrimal gland and has a significant association with the risk of dry eye in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Eye Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.exer.2022.109020"}], "href": "https://doi.org/10.1016/j.exer.2022.109020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35240198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35240198"}]}]}]}
Synonyms	MMCAT, ADAMTS21, KNO2
Proteins	ATS18_HUMAN
NCBI Gene ID	170692
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ADAMTS18 has 4,191 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 107 datasets.

Click the + buttons to view associations for ADAMTS18 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ADAMTS18 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ADAMTS18 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAMTS18 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAMTS18 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ADAMTS18 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ADAMTS18 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ADAMTS18 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADAMTS18 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAMTS18 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADAMTS18 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADAMTS18 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ADAMTS18 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with ADAMTS18 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ADAMTS18 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAMTS18 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ADAMTS18 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ADAMTS18 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with ADAMTS18 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with ADAMTS18 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of ADAMTS18 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ADAMTS18 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ADAMTS18 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ADAMTS18 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ADAMTS18 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADAMTS18 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ADAMTS18 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with ADAMTS18 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ADAMTS18 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ADAMTS18 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for ADAMTS18 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ADAMTS18 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ADAMTS18 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ADAMTS18 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ADAMTS18 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ADAMTS18 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ADAMTS18 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ADAMTS18 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADAMTS18 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ADAMTS18 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ADAMTS18 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ADAMTS18 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.