ADCYAP1R1 Gene

HGNC Family G protein-coupled receptors
Name adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
Description This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ADCYAP1R1 encodes the pituitary adenylate cyclase‐activating polypeptide type I receptor (PAC1R), a multifunctional class B G protein–coupled receptor that mediates a broad range of PACAP effects in both the central nervous system and peripheral tissues. A series of studies have demonstrated that PAC1R is essential for regulating stress responses, fear processing, and neuroendocrine adaptation—with common genetic variants (e.g., rs2267735) showing sex‐specific associations with posttraumatic stress disorder that are thought to be driven by estrogen‐dependent transcriptional mechanisms."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": " Structural and biochemical analyses have elucidated the molecular interactions between PACAP and the extracellular domain of PAC1R, revealing how hormone binding initiates intracellular signaling pathways—including activation of adenylyl cyclase, phospholipase C, and the ERK cascade."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": " In addition, PAC1R signaling contributes to neural stem cell proliferation, synaptic plasticity, and memory formation, and it plays a neuroprotective role in models of ischemia, spinal cord injury, and pulmonary hypertension."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "14"}]}, {"type": "t", "text": " Epigenetic modifications of ADCYAP1R1, as well as genetic variation, have been linked not only to neuropsychiatric conditions but also to respiratory and metabolic dysregulation such as asthma and childhood obesity"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "18"}]}, {"type": "t", "text": ", while additional work has implicated ADCYAP1R1 variation in susceptibility to cluster headache."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": " Collectively, these findings underscore the pivotal role of ADCYAP1R1/PAC1R in orchestrating stress, inflammatory, and neuroprotective signaling—with important implications for treating neuropsychiatric, cardiovascular, and metabolic disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}, {"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kerry J Ressler, Kristina B Mercer, Bekh Bradley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09856"}], "href": "https://doi.org/10.1038/nature09856"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21350482"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21350482"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jennifer Strafford Stevens, Lynn M Almli, Negar Fani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1318954111"}], "href": "https://doi.org/10.1073/pnas.1318954111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24516127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24516127"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lynn M Almli, Kristina B Mercer, Kimberly Kerley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADCYAP1R1 genotype associates with post-traumatic stress symptoms in highly traumatized African-American females."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.32145"}], "href": "https://doi.org/10.1002/ajmg.b.32145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23505260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23505260"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Li Wang, Chengqi Cao, Richu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Affect Disord (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jad.2013.01.010"}], "href": "https://doi.org/10.1016/j.jad.2013.01.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23394710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23394710"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "K B Mercer, B Dias, D Shafer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional evaluation of a PTSD-associated genetic variant: estradiol regulation and ADCYAP1R1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tp.2016.241"}], "href": "https://doi.org/10.1038/tp.2016.241"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27959335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27959335"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mackenzie J Lind, Marisa E Marraccini, Christina M Sheerin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of Posttraumatic Stress Disorder With rs2267735 in the ADCYAP1R1 Gene: A Meta-Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Trauma Stress (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jts.22211"}], "href": "https://doi.org/10.1002/jts.22211"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28746747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28746747"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chaohong Sun, Danying Song, Rachel A Davis-Taber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0611397104"}], "href": "https://doi.org/10.1073/pnas.0611397104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17470806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17470806"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Shogo Matsuyama, Akira Matsumoto, Hitoshi Hashimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impaired long-term potentiation in vivo in the dentate gyrus of pituitary adenylate cyclase-activating polypeptide (PACAP) or PACAP type 1 receptor-mutant mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroreport (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/00001756-200311140-00017"}], "href": "https://doi.org/10.1097/00001756-200311140-00017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14600504"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14600504"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Nicolas Delcourt, Eric Thouvenot, Benjamin Chanrion, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PACAP type I receptor transactivation is essential for IGF-1 receptor signalling and antiapoptotic activity in neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601608"}], "href": "https://doi.org/10.1038/sj.emboj.7601608"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17332755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17332755"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Victor May, Thomas R Buttolph, Beatrice M Girard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PACAP-induced ERK activation in HEK cells expressing PAC1 receptors involves both receptor internalization and PKC signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00001.2014"}], "href": "https://doi.org/10.1152/ajpcell.00001.2014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24696141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24696141"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kazuhiro Kobayashi, Wataru Shihoya, Tomohiro Nishizawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-020-0386-8"}], "href": "https://doi.org/10.1038/s41594-020-0386-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32157248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32157248"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Alex Mercer, Harriet Rönnholm, Johan Holmberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PACAP promotes neural stem cell proliferation in adult mouse brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jnr.20038"}], "href": "https://doi.org/10.1002/jnr.20038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15048918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15048918"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Christiane Otto, Lutz Hein, Marc Brede, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pulmonary hypertension and right heart failure in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.CIR.0000147235.53360.59"}], "href": "https://doi.org/10.1161/01.CIR.0000147235.53360.59"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15520307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15520307"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Arnaud Nicot, Timothy Otto, Philippe Brabet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered social behavior in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1910-04.2004"}], "href": "https://doi.org/10.1523/JNEUROSCI.1910-04.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15470144"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15470144"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Wei Chen, Nadia Boutaoui, John M Brehm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADCYAP1R1 and asthma in Puerto Rican children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Crit Care Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1164/rccm.201210-1789OC"}], "href": "https://doi.org/10.1164/rccm.201210-1789OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23328528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23328528"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Monica Uddin, Shun-Chiao Chang, Chao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adcyap1r1 genotype, posttraumatic stress disorder, and depression among women exposed to childhood maltreatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Depress Anxiety (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/da.22037"}], "href": "https://doi.org/10.1002/da.22037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23280952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23280952"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Alison G Paquette, Barry M Lester, Corina Lesseur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placental epigenetic patterning of glucocorticoid response genes is associated with infant neurodevelopment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenomics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/epi.15.28"}], "href": "https://doi.org/10.2217/epi.15.28"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26343289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26343289"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "M Samblas, F I Milagro, M L Mansego, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTPRS and PER3 methylation levels are associated with childhood obesity: results from a genome-wide methylation analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Obes (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/ijpo.12224"}], "href": "https://doi.org/10.1111/ijpo.12224"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28614626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28614626"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Elena Bacchelli, Maria Michela Cainazzo, Cinzia Cameli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Headache Pain (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s10194-016-0705-y"}], "href": "https://doi.org/10.1186/s10194-016-0705-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27957625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27957625"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "S Bradley King, Donna J Toufexis, Sayamwong E Hammack "}, {"type": "b", "children": [{"type": "t", "text": "Pituitary adenylate cyclase activating polypeptide (PACAP), stress, and sex hormones."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stress (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/10253890.2017.1336535"}], "href": "https://doi.org/10.1080/10253890.2017.1336535"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28610473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28610473"}]}]}]}
Synonyms PACAPR, PACAPRI, PAC1, PAC1R
Proteins PACR_HUMAN
NCBI Gene ID 117
API
Download Associations
Predicted Functions View ADCYAP1R1's ARCHS4 Predicted Functions.
Co-expressed Genes View ADCYAP1R1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View ADCYAP1R1's ARCHS4 Predicted Functions.

Functional Associations

ADCYAP1R1 has 4,731 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 107 datasets.

Click the + buttons to view associations for ADCYAP1R1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Achilles Cell Line Gene Essentiality Profiles cell lines with fitness changed by ADCYAP1R1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of ADCYAP1R1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles tissues with high or low expression of ADCYAP1R1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of ADCYAP1R1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of ADCYAP1R1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of ADCYAP1R1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of ADCYAP1R1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of ADCYAP1R1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of ADCYAP1R1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of ADCYAP1R1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of ADCYAP1R1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with ADCYAP1R1 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADCYAP1R1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of ADCYAP1R1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of ADCYAP1R1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of ADCYAP1R1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing ADCYAP1R1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with ADCYAP1R1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with ADCYAP1R1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of ADCYAP1R1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with ADCYAP1R1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with ADCYAP1R1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations diseases associated with ADCYAP1R1 gene/protein from the curated CTD Gene-Disease Associations dataset.
dbGAP Gene-Trait Associations traits associated with ADCYAP1R1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by ADCYAP1R1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores diseases associated with ADCYAP1R1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with ADCYAP1R1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with ADCYAP1R1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with ADCYAP1R1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with ADCYAP1R1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with ADCYAP1R1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at ADCYAP1R1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADCYAP1R1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of ADCYAP1R1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing ADCYAP1R1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations diseases associated with ADCYAP1R1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations diseases associated with ADCYAP1R1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of ADCYAP1R1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with ADCYAP1R1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing ADCYAP1R1 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of ADCYAP1R1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of ADCYAP1R1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of ADCYAP1R1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of ADCYAP1R1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of ADCYAP1R1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of ADCYAP1R1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving ADCYAP1R1 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving ADCYAP1R1 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving ADCYAP1R1 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing ADCYAP1R1 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing ADCYAP1R1 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing ADCYAP1R1 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by ADCYAP1R1 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by ADCYAP1R1 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by ADCYAP1R1 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of ADCYAP1R1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of ADCYAP1R1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of ADCYAP1R1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
Guide to Pharmacology Chemical Ligands of Receptors ligands (chemical) binding ADCYAP1R1 receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.
Guide to Pharmacology Protein Ligands of Receptors ligands (protein) binding ADCYAP1R1 receptor from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.
GWASdb SNP-Disease Associations diseases associated with ADCYAP1R1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with ADCYAP1R1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of ADCYAP1R1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of ADCYAP1R1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of ADCYAP1R1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of ADCYAP1R1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
HPM Cell Type and Tissue Protein Expression Profiles cell types and tissues with high or low expression of ADCYAP1R1 protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset.
Hub Proteins Protein-Protein Interactions interacting hub proteins for ADCYAP1R1 from the curated Hub Proteins Protein-Protein Interactions dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with ADCYAP1R1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by ADCYAP1R1 gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for ADCYAP1R1 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of ADCYAP1R1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEGG Pathways pathways involving ADCYAP1R1 protein from the KEGG Pathways dataset.
Kinase Library Serine Threonine Kinome Atlas kinases that phosphorylate ADCYAP1R1 protein from the Kinase Library Serine Threonine Atlas dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of ADCYAP1R1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of ADCYAP1R1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of ADCYAP1R1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LOCATE Curated Protein Localization Annotations cellular components containing ADCYAP1R1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain ADCYAP1R1 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by ADCYAP1R1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of ADCYAP1R1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of ADCYAP1R1 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by ADCYAP1R1 gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of ADCYAP1R1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of ADCYAP1R1 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for ADCYAP1R1 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of ADCYAP1R1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of ADCYAP1R1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving ADCYAP1R1 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving ADCYAP1R1 protein from the Wikipathways PFOCR 2024 dataset.
Reactome Pathways 2014 pathways involving ADCYAP1R1 protein from the Reactome Pathways dataset.
Reactome Pathways 2024 pathways involving ADCYAP1R1 protein from the Reactome Pathways 2024 dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of ADCYAP1R1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at ADCYAP1R1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of ADCYAP1R1 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of ADCYAP1R1 gene from the RummaGEO Gene Perturbation Signatures dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of ADCYAP1R1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of ADCYAP1R1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of ADCYAP1R1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of ADCYAP1R1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of ADCYAP1R1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of ADCYAP1R1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of ADCYAP1R1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with ADCYAP1R1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with ADCYAP1R1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2014 pathways involving ADCYAP1R1 protein from the Wikipathways Pathways 2014 dataset.
WikiPathways Pathways 2024 pathways involving ADCYAP1R1 protein from the WikiPathways Pathways 2024 dataset.