ADD1 Gene

Name	adducin 1 (alpha)
Description	Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Adducin, particularly its alpha‐adducin isoform (ADD1), is emerging as a multifunctional protein with distinct tissue‐dependent roles. In adipose tissue, ADD1 also functions as adipocyte determination and differentiation factor 1 (ADD1/SREBP1c) that is robustly induced during the early stages of adipogenesis. Its upregulation not only accelerates preadipocyte proliferation and differentiation—coinciding with enhanced expression of key adipogenic regulators and increased lipid droplet accumulation—but also improves insulin responsiveness through augmented GLUT4 expression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In parallel, considerable evidence links genetic variants of alpha‐adducin—most notably the Gly460Trp polymorphism—to altered renal sodium handling and blood pressure regulation. Mutated forms of ADD1 are associated with impaired Na+/K+‐ATPase endocytosis, leading to increased pump surface expression, enhanced sodium reabsorption, and salt‐sensitive hypertension. Such alterations in renal tubular transport contribute to cardiovascular risk and have been shown to influence the response to diuretic therapies as well as the incidence of myocardial infarction and stroke."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in transcriptional regulation and renal sodium handling, ADD1 serves as a critical cytoskeletal component. It promotes the assembly and stability of spectrin–actin complexes that maintain membrane integrity in diverse cell types including red blood cells, neurons, and epithelial cells. In neurons, for example, adducin helps regulate the diameter of periodic actin rings, thereby preserving axonal architecture, while in epithelial cells it contributes to the dynamic remodeling of cell–cell junctions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, post‐translational modifications of adducin are implicated in neural function. Loss of regulation by microRNAs and subsequent aberrant phosphorylation of adducin—as mediated by ROCK2—have been linked to synaptic dysfunction and memory deficits in models of Alzheimer’s disease, highlighting a role for ADD1 in maintaining proper synaptic connectivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies underscore the multifaceted functions of ADD1, which range from acting as a transcriptional activator in adipocyte differentiation to modulating cytoskeletal organization crucial for maintaining cellular integrity and proper sodium transport. The diverse roles of ADD1 in metabolic regulation, blood pressure homeostasis, and neural activity highlight its potential as a key mediator in the pathophysiology of metabolic, cardiovascular, and neurological disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuchang Fu, Nanlan Luo, Richard L Klein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M400373-JLR200"}], "href": "https://doi.org/10.1194/jlr.M400373-JLR200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15834118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15834118"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sucharita Sen Banerjee, Mark W Feinberg, Masafumi Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Krüppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M210859200"}], "href": "https://doi.org/10.1074/jbc.M210859200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12426306"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12426306"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yun Sok Lee, Hyoung Ho Lee, Jiyoung Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkg934"}], "href": "https://doi.org/10.1093/nar/gkg934"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14654692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14654692"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "J A Staessen, J G Wang, E Brand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hypertens (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/00004872-200108000-00002"}], "href": "https://doi.org/10.1097/00004872-200108000-00002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11518842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11518842"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Bruce M Psaty, Nicholas L Smith, Susan R Heckbert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diuretic therapy, the alpha-adducin gene variant, and the risk of myocardial infarction or stroke in persons with treated hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JAMA (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/jama.287.13.1680"}], "href": "https://doi.org/10.1001/jama.287.13.1680"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11926892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11926892"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Martin D Tobin, Peter S Braund, Paul R Burton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genotypes and haplotypes predisposing to myocardial infarction: a multilocus case-control study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Heart J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ehj.2003.11.014"}], "href": "https://doi.org/10.1016/j.ehj.2003.11.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15039125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15039125"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Riad Efendiev, Rafael T Krmar, Goichi Ogimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase trafficking in response to GPCR signals and intracellular sodium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000149570.20845.89"}], "href": "https://doi.org/10.1161/01.RES.0000149570.20845.89"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15528469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15528469"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nicola Glorioso, Fabiana Filigheddu, Daniele Cusi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "alpha-Adducin 460Trp allele is associated with erythrocyte Na transport rate in North Sardinian primary hypertensives."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/hy0202.103065"}], "href": "https://doi.org/10.1161/hy0202.103065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11882573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11882573"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ken Sugimoto, Atsushi Hozawa, Tomohiro Katsuya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "alpha-Adducin Gly460Trp polymorphism is associated with low renin hypertension in younger subjects in the Ohasama study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hypertens (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/00004872-200209000-00022"}], "href": "https://doi.org/10.1097/00004872-200209000-00022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12195119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12195119"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Paolo Manunta, Marc Maillard, Cristina Tantardini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hypertens (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/HJH.0b013e3282f5315f"}], "href": "https://doi.org/10.1097/HJH.0b013e3282f5315f"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18398333"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18398333"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lucia Torielli, Simona Tivodar, Rosa Chiara Montella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "alpha-Adducin mutations increase Na/K pump activity in renal cells by affecting constitutive endocytosis: implications for tubular Na reabsorption."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.90226.2008"}], "href": "https://doi.org/10.1152/ajprenal.90226.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18524856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18524856"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sérgio Carvalho Leite, Paula Sampaio, Vera Filipe Sousa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.03.047"}], "href": "https://doi.org/10.1016/j.celrep.2016.03.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27068466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27068466"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Raymond F Robledo, Steven L Ciciotte, Babette Gwynn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-05-156000"}], "href": "https://doi.org/10.1182/blood-2008-05-156000"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18723693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18723693"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Nayden G Naydenov, Andrei I Ivanov "}, {"type": "b", "children": [{"type": "t", "text": "Adducins regulate remodeling of apical junctions in human epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E10-03-0259"}], "href": "https://doi.org/10.1091/mbc.E10-03-0259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20810786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20810786"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kai Zheng, Fan Hu, Yang Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-22196-y"}], "href": "https://doi.org/10.1038/s41467-021-22196-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33771994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33771994"}]}]}]}
Synonyms	ADDA
Proteins	ADDA_HUMAN
NCBI Gene ID	118
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ADD1 has 9,090 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 137 datasets.

Click the + buttons to view associations for ADD1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ADD1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ADD1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADD1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADD1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ADD1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ADD1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ADD1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADD1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ADD1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADD1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADD1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ADD1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADD1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ADD1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ADD1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ADD1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADD1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ADD1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ADD1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with ADD1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ADD1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ADD1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ADD1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ADD1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ADD1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ADD1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ADD1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ADD1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADD1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ADD1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ADD1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ADD1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ADD1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ADD1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ADD1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ADD1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ADD1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ADD1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ADD1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ADD1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ADD1 gene from the ENCODE Histone Modification Site Profiles dataset.