ADGRG6 Gene

HGNC Family	G protein-coupled receptors
Name	adhesion G protein-coupled receptor G6
Description	This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ADGRG6 (also known as GPR126) is an adhesion‐G protein–coupled receptor with multifaceted roles in human physiology and development. Studies have implicated ADGRG6 in respiratory function, with genetic association analyses linking variants in this gene to lung function measures such as FEV<sub>1</sub>/FVC ratios."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the realm of skeletal biology, genome‐wide analyses have shown that ADGRG6 variants contribute to variability in human height and distinct skeletal subcomponents, while dysfunction in its regulation has been associated with adolescent idiopathic scoliosis and altered cartilage expression and spinal ossification."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": " Additionally, ADGRG6 has emerged as a critical regulator of peripheral nervous system development. It is required in Schwann cells for proper axonal sorting and myelin sheath formation through mechanisms that involve direct coupling to heterotrimeric G proteins to elevate intracellular cAMP levels."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, studies demonstrate that activation of ADGRG6 by the flexible tail of PrP(C) can promote myelin homeostasis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and that loss of ADGRG6 function impairs remyelination and disrupts the coordinated recruitment of macrophages and axon regeneration following nerve injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In model systems, targeted mutation of ADGRG6 has revealed its necessity for embryonic viability and normal cardiovascular development, while in humans, homozygous mutations result in arthrogryposis multiplex congenita, underscoring its importance for neuromuscular integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Finally, somatic noncoding mutations affecting ADGRG6 enhancer elements have been linked to aberrant tumor angiogenesis in bladder cancer, highlighting an oncogenic facet of its biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings position ADGRG6 as a critical mediator that not only orchestrates peripheral nerve myelination and repair through cAMP‐dependent signaling, but also influences skeletal development, cardiogenesis, and even tumor angiogenesis. This diverse spectrum of functions underscores the receptor’s potential as a therapeutic target across a range of pathological conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dana B Hancock, Mark Eijgelsheim, Jemma B Wilk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.500"}], "href": "https://doi.org/10.1038/ng.500"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20010835"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20010835"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nicole Soranzo, Fernando Rivadeneira, Usha Chinappen-Horsley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1000445"}], "href": "https://doi.org/10.1371/journal.pgen.1000445"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19343178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19343178"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ikuyo Kou, Yohei Takahashi, Todd A Johnson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2639"}], "href": "https://doi.org/10.1038/ng.2639"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23666238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23666238"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jimmy Z Liu, Sarah E Medland, Margaret J Wright, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of height and body mass index in Australian twin families."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Twin Res Hum Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1375/twin.13.2.179"}], "href": "https://doi.org/10.1375/twin.13.2.179"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20397748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20397748"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kelly R Monk, Kazuo Oshima, Simone Jörs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gpr126 is essential for peripheral nerve development and myelination in mammals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.062224"}], "href": "https://doi.org/10.1242/dev.062224"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21613327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21613327"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Amit Mogha, Andrew E Benesh, Chinmoy Patra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1809-13.2013"}], "href": "https://doi.org/10.1523/JNEUROSCI.1809-13.2013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24227709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24227709"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Alexander Küffer, Asvin K K Lakkaraju, Amit Mogha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature19312"}], "href": "https://doi.org/10.1038/nature19312"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27501152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27501152"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Amit Mogha, Breanne L Harty, Dan Carlin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gpr126/Adgrg6 Has Schwann Cell Autonomous and Nonautonomous Functions in Peripheral Nerve Injury and Repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.3854-15.2016"}], "href": "https://doi.org/10.1523/JNEUROSCI.3854-15.2016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27927955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27927955"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Helen Waller-Evans, Simone Prömel, Tobias Langenhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0014047"}], "href": "https://doi.org/10.1371/journal.pone.0014047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21124978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21124978"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Courtney M Karner, Fanxin Long, Lilianna Solnica-Krezel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddv170"}], "href": "https://doi.org/10.1093/hmg/ddv170"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25954032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25954032"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Dao-Lai Zhang, Yu-Jing Sun, Ming-Liang Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.33432"}], "href": "https://doi.org/10.7554/eLife.33432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29393851"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29393851"}]}]}]}
Synonyms	GPR126, VIGR, LCCS9, APG1, PS1TP2, PR126, DREG
Proteins	GP126_HUMAN
NCBI Gene ID	57211
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ADGRG6 has 10,703 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 127 datasets.

Click the + buttons to view associations for ADGRG6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ADGRG6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ADGRG6 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADGRG6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADGRG6 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ADGRG6 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ADGRG6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ADGRG6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADGRG6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ADGRG6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADGRG6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADGRG6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ADGRG6 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADGRG6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ADGRG6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ADGRG6 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ADGRG6 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADGRG6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ADGRG6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ADGRG6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with ADGRG6 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of ADGRG6 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ADGRG6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ADGRG6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ADGRG6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ADGRG6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ADGRG6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADGRG6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ADGRG6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ADGRG6 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	dbGAP Gene-Trait Associations	traits associated with ADGRG6 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ADGRG6 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ADGRG6 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ADGRG6 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ADGRG6 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ADGRG6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ADGRG6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ADGRG6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ADGRG6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ADGRG6 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADGRG6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ADGRG6 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.