ADNP Gene

HGNC Family	Homeoboxes
Name	activity-dependent neuroprotector homeobox
Description	Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Activity‐dependent neuroprotective protein (ADNP) is a multifunctional protein essential for proper embryonic brain formation, neurogenesis, and synaptic plasticity. ADNP acts as a transcriptional regulator through its association with chromatin remodeling complexes such as SWI/SNF, thereby modulating the expression of genes critical for neural differentiation and organogenesis; loss‐of‐function or haploinsufficiency leads to neural tube defects, intellectual disability, and a syndromic form of autism (the Helsmoortel–Van der Aa syndrome)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": " Moreover, ADNP regulates microtubule dynamics by interacting with end‐binding proteins (EB1/EB3) and by virtue of its NAP (NAPVSIPQ) motif, which promotes dendritic spine formation and safeguards against tauopathy and neurodegeneration; these properties have spurred development of NAP as a potential therapeutic agent in disorders ranging from Alzheimer’s disease to schizophrenia."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "11"}]}, {"type": "t", "text": " In addition, ADNP contributes to autophagy regulation and cell survival pathways that are vital for maintaining neuronal homeostasis, and its dysregulation is observed across a spectrum of neurodevelopmental and neurodegenerative disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " ADNP expression is dynamically regulated during development and by neurotrophic factors such as VIP and PACAP, which may direct its cell type–specific functions in neurons and astrocytes, while sexual dimorphism in its expression has been noted in brain regions involved in cognitive and homeostatic regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "17"}]}, {"type": "t", "text": " Finally, emerging evidence indicates that ADNP and its peptide derivatives can ameliorate synaptic and cognitive impairments in murine models, underscoring its promise as a target for translational interventions in autism spectrum disorders, Alzheimer’s disease, and other conditions marked by impaired neuroprotection."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "21"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Céline Helsmoortel, Anneke T Vulto-van Silfhout, Bradley P Coe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2899"}], "href": "https://doi.org/10.1038/ng.2899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24531329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24531329"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Albert Pinhasov, Shmuel Mandel, Arkady Torchinsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activity-dependent neuroprotective protein: a novel gene essential for brain formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res Dev Brain Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0165-3806(03)00162-7"}], "href": "https://doi.org/10.1016/s0165-3806(03"}, {"type": "t", "text": "00162-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12888219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12888219"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shmuel Mandel, Gideon Rechavi, Illana Gozes "}, {"type": "b", "children": [{"type": "t", "text": "Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2006.11.039"}], "href": "https://doi.org/10.1016/j.ydbio.2006.11.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17222401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17222401"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Eric G Bend, Erfan Aref-Eshghi, David B Everman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene domain-specific DNA methylation episignatures highlight distinct molecular entities of ADNP syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Epigenetics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13148-019-0658-5"}], "href": "https://doi.org/10.1186/s13148-019-0658-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31029150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31029150"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Anne B Arnett, Candace L Rhoads, Kendra Hoekzema, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Activity-dependent neuroprotector homeobox protein: A candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteomics (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jprot.2012.04.017"}], "href": "https://doi.org/10.1016/j.jprot.2012.04.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22554909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22554909"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Gal Hacohen-Kleiman, Shlomo Sragovich, Gidon Karmon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI98199"}], "href": "https://doi.org/10.1172/JCI98199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30106381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30106381"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Gidon Karmon, Shlomo Sragovich, Gal Hacohen-Kleiman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel ADNP Syndrome Mice Reveal Dramatic Sex-Specific Peripheral Gene Expression With Brain Synaptic and Tau Pathologies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2021.09.018"}], "href": "https://doi.org/10.1016/j.biopsych.2021.09.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34865853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34865853"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yanina Ivashko-Pachima, Maram Ganaiem, Inbar Ben-Horin-Hazak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SH3- and actin-binding domains connect ADNP and SHANK3, revealing a fundamental shared mechanism underlying autism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41380-022-01603-w"}], "href": "https://doi.org/10.1038/s41380-022-01603-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35538192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35538192"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "A Merenlender-Wagner, A Malishkevich, Z Shemer, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-16799-0"}], "href": "https://doi.org/10.1038/s41467-020-16799-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32533114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32533114"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Sharon Furman, Joanna M Hill, Inna Vulih, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sexual dimorphism of activity-dependent neuroprotective protein in the mouse arcuate nucleus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2004.09.077"}], "href": "https://doi.org/10.1016/j.neulet.2004.09.077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15555780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15555780"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Shlomo Sragovich, Yarden Ziv, Sharon Vaisvaser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The autism-mutated ADNP plays a key role in stress response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-019-0569-4"}], "href": "https://doi.org/10.1038/s41398-019-0569-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31534115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31534115"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "A Malishkevich, N Amram, G Hacohen-Kleiman, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-018-0357-6"}], "href": "https://doi.org/10.1038/s41398-018-0357-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30664622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30664622"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Michael S Breen, Paras Garg, Lara Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Episignatures Stratifying Helsmoortel-Van Der Aa Syndrome Show Modest Correlation with Phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2020.07.003"}], "href": "https://doi.org/10.1016/j.ajhg.2020.07.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32758449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32758449"}]}]}]}
Synonyms	HVDAS, MRD28, ADNP1
Proteins	ADNP_HUMAN
NCBI Gene ID	23394
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ADNP has 8,973 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 121 datasets.

Click the + buttons to view associations for ADNP from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ADNP Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ADNP gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADNP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADNP gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ADNP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ADNP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADNP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ADNP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADNP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADNP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADNP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ADNP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ADNP protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ADNP gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADNP gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ADNP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ADNP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with ADNP gene from the curated ClinVar Gene-Phenotype Associations dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ADNP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ADNP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ADNP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ADNP protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ADNP protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ADNP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ADNP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADNP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ADNP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ADNP gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ADNP gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ADNP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving ADNP gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ADNP gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ADNP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ADNP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ADNP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ADNP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ADNP gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADNP gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ADNP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ADNP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with ADNP gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.