ADNP2 Gene

HGNC Family	Homeoboxes, Zinc fingers
Name	ADNP homeobox 2
Description	Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in nervous system development and regulation of gene expression. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ADNP2 is a homolog of the activity‐dependent neuroprotective protein (ADNP) that is widely expressed—with particularly high levels in the brain during both development and adulthood—and appears to play a key role in cellular survival and stress responses. Functional studies have demonstrated that loss or deficiency of ADNP2 increases vulnerability to oxidative stress in neural and neuroglial cells, suggesting that it participates in protective pathways that maintain neuronal integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, altered ADNP2 expression has been documented in neuropsychiatric disorders. For instance, in schizophrenia patients an imbalance between ADNP and ADNP2 transcript levels in the hippocampus and prefrontal cortex may contribute to disease progression, possibly via disruption of autophagy and anti‐apoptotic mechanisms."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": " Regulation of ADNP2 expression is, in part, modulated by vasoactive intestinal peptide (VIP), as evidenced by regionally specific reductions in ADNP2 mRNA in VIP‐deficient mice."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Beyond the nervous system, ADNP2 is also upregulated in FGFR2‐overexpressing osteoblasts, implying additional roles in growth factor–mediated pathways"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while genomic deletions and de novo mutations involving the ADNP2 gene have been associated with autistic phenotypes and may contribute to syndromic presentations in disorders such as 22q11.2 deletion syndrome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, modulation of ADNP2 is evident in models of neurodevelopment and even in songbirds where its expression correlates with genes involved in speech and auditory processing"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and emerging evidence suggests that in peripheral blood ADNP2 transcripts may serve as biomarkers for Alzheimer’s disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Finally, proteomic screens also indicate that ADNP2 may be among gene candidates that influence cellular responses to ionizing radiation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and its regulation can be affected by microRNAs linked to neural development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore ADNP2’s importance as a neuroprotective factor that influences cell survival, neural development, and stress responsiveness, with potential implications for the pathophysiology and treatment of neurodevelopmental, neuropsychiatric, and neurodegenerative disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michal Kushnir, Efrat Dresner, Shmuel Mandel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of the ADNP-family member, ADNP2, results in changes in cellular viability under oxidative stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2007.05173.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2007.05173.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18179478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18179478"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "A Merenlender-Wagner, A Malishkevich, Z Shemer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autophagy has a key role in the pathophysiology of schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2013.174"}], "href": "https://doi.org/10.1038/mp.2013.174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24365867"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24365867"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Efrat Dresner, Galila Agam, Illana Gozes "}, {"type": "b", "children": [{"type": "t", "text": "Activity-dependent neuroprotective protein (ADNP) expression level is correlated with the expression of the sister protein ADNP2: deregulation in schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Neuropsychopharmacol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.euroneuro.2010.06.004"}], "href": "https://doi.org/10.1016/j.euroneuro.2010.06.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20598862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20598862"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Illana Gozes "}, {"type": "b", "children": [{"type": "t", "text": "Microtubules, schizophrenia and cognitive behavior: preclinical development of davunetide (NAP) as a peptide-drug candidate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Peptides (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.peptides.2010.10.030"}], "href": "https://doi.org/10.1016/j.peptides.2010.10.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21050875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21050875"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Eliezer Giladi, Joanna M Hill, Efrat Dresner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasoactive intestinal peptide (VIP) regulates activity-dependent neuroprotective protein (ADNP) expression in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-007-9003-0"}], "href": "https://doi.org/10.1007/s12031-007-9003-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17952637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17952637"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Tianyi Cai, Baojin Wu, Xinjie Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "iTRAQ-Based Proteomic Analysis reveals possible target-related proteins and signal networks in human osteoblasts overexpressing FGFR2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proteome Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12953-018-0140-x"}], "href": "https://doi.org/10.1186/s12953-018-0140-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29950929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29950929"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xuelian He, Peiwei Zhao, Yufeng Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Genome-wide copy number microarray analysis for a boy with autism]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.issn.1003-9406.2019.02.016"}], "href": "https://doi.org/10.3760/cma.j.issn.1003-9406.2019.02.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30703237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30703237"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jonathan H Chung, Jinlu Cai, Barrie G Suskin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole-Genome Sequencing and Integrative Genomic Analysis Approach on Two 22q11.2 Deletion Syndrome Family Trios for Genotype to Phenotype Correlations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.22814"}], "href": "https://doi.org/10.1002/humu.22814"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25981510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25981510"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Gal Hacohen-Kleiman, Stan Moaraf, Oxana Kapitansky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sex-and Region-Dependent Expression of the Autism-Linked ADNP Correlates with Social- and Speech-Related Genes in the Canary Brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-020-01700-x"}], "href": "https://doi.org/10.1007/s12031-020-01700-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32926339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32926339"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Anna Malishkevich, Gad A Marshall, Aaron P Schultz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-150799"}], "href": "https://doi.org/10.3233/JAD-150799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26639975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26639975"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kimberly Loesch, Stacy Galaviz, Zaher Hamoui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0120534"}], "href": "https://doi.org/10.1371/journal.pone.0120534"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25853515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25853515"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jing Lu, Yan Zhu, Sarah Williams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autism-associated miR-873 regulates ARID1B, SHANK3 and NRXN2 involved in neurodevelopment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-020-01106-8"}], "href": "https://doi.org/10.1038/s41398-020-01106-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33262327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33262327"}]}]}]}
Synonyms	ZNF508
Proteins	ADNP2_HUMAN
NCBI Gene ID	22850
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ADNP2 has 5,408 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 108 datasets.

Click the + buttons to view associations for ADNP2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ADNP2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADNP2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADNP2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ADNP2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ADNP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ADNP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ADNP2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ADNP2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADNP2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ADNP2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ADNP2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADNP2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ADNP2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ADNP2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ADNP2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADNP2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ADNP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ADNP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of ADNP2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ADNP2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ADNP2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ADNP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ADNP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ADNP2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ADNP2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ADNP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ADNP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ADNP2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ADNP2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ADNP2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ADNP2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ADNP2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ADNP2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ADNP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ADNP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ADNP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ADNP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ADNP2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ADNP2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ADNP2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ADNP2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.