{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the provided abstracts shows that the collective research focuses extensively on the roles of microRNA‐124 (miR-124) in regulating neural development, neuronal differentiation, synaptic plasticity, neuroinflammation, and related processes. For example, several studies detail how miR-124 governs the progression of neural precursor cells into mature neurons."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nHowever, none of these abstracts mention or provide any information regarding the gene AGAP6 or its function. Whether in the context of cytoskeletal regulation, vesicular trafficking, or intracellular signaling—the common biological roles attributed to AGAP family proteins—no data is presented that pertains to AGAP6."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe remaining abstracts continue to explore the diverse roles of miR-124 (and associated miRNAs) in additional contexts—including muscular differentiation, metabolic regulation, neurotoxic insults, aging, and stress responses—but none address any function of AGAP6."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "36"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while the abstracts deliver a wealth of information on miR-124–mediated regulation in various cellular and disease contexts, they do not address AGAP6. 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"}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-124 protects neurons against apoptosis in cerebral ischemic stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "CNS Neurosci Ther (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cns.12142"}], "href": "https://doi.org/10.1111/cns.12142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23826665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23826665"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Garrett A Soukup, Bernd Fritzsch, Marsha L Pierce, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2009.01.037"}], "href": "https://doi.org/10.1016/j.ydbio.2009.01.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19389351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19389351"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Zongwei Li, Yaying Song, Tingting He, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroinflammation (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12974-018-1053-4"}], "href": "https://doi.org/10.1186/s12974-018-1053-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29329581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29329581"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Du Yue, Gao Guanqun, Li Jingxin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of long noncoding RNA XIST attenuated Alzheimer's disease-related BACE1 alteration through miR-124."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.11263"}], "href": "https://doi.org/10.1002/cbin.11263"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31743528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31743528"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xi Gu, Congcong Fu, Lifang Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-124 and miR-9 mediated downregulation of HDAC5 promotes neurite development through activating MEF2C-GPM6A pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.25927"}], "href": "https://doi.org/10.1002/jcp.25927"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28332716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28332716"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jerome Dickstein, Vitalyi Senyuk, Kavitha Premanand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1004297107"}], "href": "https://doi.org/10.1073/pnas.1004297107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20448201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20448201"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Francisca M Real, Ryohei Sekido, Darío G Lupiáñez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A microRNA (mmu-miR-124) prevents Sox9 expression in developing mouse ovarian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.113.110957"}], "href": "https://doi.org/10.1095/biolreprod.113.110957"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23946534"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23946534"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Palanikumar Manoharan, Joshua E Basford, Robyn Pilcher-Roberts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced levels of microRNAs miR-124a and miR-150 are associated with increased proinflammatory mediator expression in Krüppel-like factor 2 (KLF2)-deficient macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.579763"}], "href": "https://doi.org/10.1074/jbc.M114.579763"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25248747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25248747"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Stefanie G Wohl, Marcus J Hooper, Thomas A Reh "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNAs miR-25, let-7 and miR-124 regulate the neurogenic potential of Müller glia in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.179556"}], "href": "https://doi.org/10.1242/dev.179556"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31383796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31383796"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Sarah K Lawson, Elena Y Dobrikova, Mayya Shveygert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p38α mitogen-activated protein kinase depletion and repression of signal transduction to translation machinery by miR-124 and -128 in neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00695-12"}], "href": "https://doi.org/10.1128/MCB.00695-12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23109423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23109423"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "K Nagata, I Hama, S Kiryu-Seo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-124 is down regulated in nerve-injured motor neurons and it potentially targets mRNAs for KLF6 and STAT3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2013.10.055"}], "href": "https://doi.org/10.1016/j.neuroscience.2013.10.055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24184980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24184980"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Abdul S Qadir, Kyung Mi Woo, Hyun-Mo Ryoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-124 inhibits myogenic differentiation of mesenchymal stem cells via targeting Dlx5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.24821"}], "href": "https://doi.org/10.1002/jcb.24821"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24733577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24733577"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Sabyasachi Dash, Muthukumar Balasubramaniam, Freddyson J Martínez-Rivera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cocaine-regulated microRNA miR-124 controls poly (ADP-ribose) polymerase-1 expression in neuronal cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-68144-6"}], "href": "https://doi.org/10.1038/s41598-020-68144-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32641757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32641757"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Haiyang Xu, Jingjing Zhang, Wei Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of miR-124 in modulating hippocampal neurotoxicity induced by ketamine anesthesia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Neurosci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/00207454.2014.919915"}], "href": "https://doi.org/10.3109/00207454.2014.919915"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24825585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24825585"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Alexandra Dallaire, Chantal Garand, Eric R Paquel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.100489"}], "href": "https://doi.org/10.18632/aging.100489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23075628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23075628"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Abdul S Qadir, Kyung Mi Woo, Hyun-Mo Ryoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin suppresses distal-less homeobox 5 expression through the up-regulation of microRNA-124 in 3T3-L1 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2013.04.020"}], "href": "https://doi.org/10.1016/j.yexcr.2013.04.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23648570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23648570"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Suman K Das, Elke Stadelmeyer, Silvia Schauer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Micro RNA-124a regulates lipolysis via adipose triglyceride lipase and comparative gene identification 58."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms16048555"}], "href": "https://doi.org/10.3390/ijms16048555"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25894224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25894224"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Yufeng Liang, Junjie Xie, Di Che, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-124-3p helps to protect against acute respiratory distress syndrome by targeting p65."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20192132"}], "href": "https://doi.org/10.1042/BSR20192132"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32391561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32391561"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Chong Wang, Nan Yao, Cai-Ling Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse microRNA-124 regulates the expression of Hes1 in P19 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Biosci (Elite Ed) (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2741/e74"}], "href": "https://doi.org/10.2741/e74"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20036862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20036862"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Fumiko Suzuki, Mariko Okuno, Tomoya Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of neural miRNAs miR-9/9* and miR-124 suppresses differentiation to Müller glia and promotes differentiation to neurons in mouse retina in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/gtc.12809"}], "href": "https://doi.org/10.1111/gtc.12809"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32979863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32979863"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Guan Wang, Haibo Zou, Chunyou Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Repression of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MicroRNA-124-3p"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Alleviates High-Fat Diet-Induced Hepatosteatosis by Targeting Pref-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Endocrinol (Lausanne) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fendo.2020.589994"}], "href": "https://doi.org/10.3389/fendo.2020.589994"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33324345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33324345"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Xiaohong Su, Xi Gu, Zhiduo Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Retinoic acid receptor gamma is targeted by microRNA-124 and inhibits neurite outgrowth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropharmacology (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuropharm.2019.05.034"}], "href": "https://doi.org/10.1016/j.neuropharm.2019.05.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31170403"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31170403"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Yaying Song, Rubing Shi, Yingjun Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "M2 Microglia Extracellular Vesicle miR-124 Regulates Neural Stem Cell Differentiation in Ischemic Stroke via AAK1/NOTCH."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stroke (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/STROKEAHA.122.041611"}], "href": "https://doi.org/10.1161/STROKEAHA.122.041611"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37586072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37586072"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Palsamy Periyasamy, Annadurai Thangaraj, Muthukumar Kannan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Epigenetic Role of miR-124 in HIV-1 Tat- and Cocaine-Mediated Microglial Activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms232315017"}], "href": "https://doi.org/10.3390/ijms232315017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36499350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36499350"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Taro Chaya, Yamato Maeda, Ryo Sugimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple knockout mouse and embryonic stem cell models reveal the role of miR-124a in neuronal maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2022.102293"}], "href": "https://doi.org/10.1016/j.jbc.2022.102293"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35868558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35868558"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Naveen Challagundla, Reena Agrawal-Rajput "}, {"type": "b", "children": [{"type": "t", "text": "microRNAs (miR 9, 124, 155 and 224) transdifferentiate mouse macrophages to neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2021.112563"}], "href": "https://doi.org/10.1016/j.yexcr.2021.112563"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33757809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33757809"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Sofia Elisa Alzuri, Nicolás Matías Rosas, Natasa Hlavacova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of miR-124-3p in regulatory mechanisms of Gpm6a expression in the hippocampus of chronically stressed rats."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jnc.15810"}], "href": "https://doi.org/10.1111/jnc.15810"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36943192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36943192"}]}]}]}