AHNAK2 Gene

Name	AHNAK nucleoprotein 2
Description	This gene encodes a large nucleoprotein. The encoded protein has a tripartite domain structure with a relatively short N-terminus and a long C-terminus, separated by a large body of repeats. The N-terminal PSD-95/Discs-large/ZO-1 (PDZ)-like domain is thought to function in the formation of stable homodimers. The encoded protein may play a role in calcium signaling by associating with calcium channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n AHNAK2 has emerged as a multifunctional protein with roles in both normal cellular scaffolding and various pathological states, particularly in cancer. Structural studies have revealed that its PDZ‐like domain forms unique, intertwined, domain‐swapped dimers that may support its function in linking the extracellular matrix to the cytoskeletal network."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, AHNAK2 is a substrate of the protein lysine mono-methyltransferase SMYD2, suggesting that post‐translational modifications regulate its activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In several malignancies, including clear cell renal cell carcinoma, pancreatic ductal adenocarcinoma, papillary thyroid carcinoma, lung adenocarcinoma, uveal melanoma, and thymic carcinoma, AHNAK2 is frequently overexpressed and its upregulation correlates with advanced tumor stage, poor overall survival, and enhanced metastatic potential."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "12"}]}, {"type": "t", "text": " Functional experiments indicate that AHNAK2 promotes cell proliferation, migration, and invasion through the activation of key signaling pathways including phosphatidylinositol 3‐kinase (PI3K), nuclear factor kappa B (NF‐κB), and Wnt/β‐catenin, thereby contributing to tumor progression and metastasis.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its oncogenic roles, AHNAK2 is also implicated in non‐classical secretory pathways. Under stress conditions, its interaction with FGF1 appears critical for the targeted transport and export of this growth factor, thereby influencing stress responses at the plasma membrane."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Furthermore, mutations in AHNAK2 have been identified in patients with autosomal recessive forms of Charcot–Marie–Tooth disease, where disruption of its interaction with periaxin may impair myelination in the peripheral nervous system."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additional studies have underscored the biomarker potential of AHNAK2. Gene expression profiling across multiple cohorts has enabled its inclusion in predictive gene panels for pancreatic ductal adenocarcinoma and gastric cancer, and its altered copy number or overexpression has been associated with tumor aggressiveness in bladder cancer and thymic carcinoma."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "17"}]}, {"type": "t", "text": " Collectively, these findings indicate that AHNAK2 functions as a scaffold and signaling regulator whose dysregulation contributes to malignant transformation and progression, making it a promising diagnostic and prognostic biomarker as well as a potential therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huijong Han, Petri Kursula "}, {"type": "b", "children": [{"type": "t", "text": "Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through domain swapping."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.554816"}], "href": "https://doi.org/10.1074/jbc.M114.554816"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24675079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24675079"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jonathan B Olsen, Xing-Jun Cao, Bomie Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.M115.053280"}], "href": "https://doi.org/10.1074/mcp.M115.053280"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26750096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26750096"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Minglei Wang, Xuefeng Li, Jin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AHNAK2 is a Novel Prognostic Marker and Oncogenic Protein for Clear Cell Renal Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.18198"}], "href": "https://doi.org/10.7150/thno.18198"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28435451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28435451"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Manoj K Bhasin, Kenneth Ndebele, Octavian Bucur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Meta-analysis of transcriptome data identifies a novel 5-gene pancreatic adenocarcinoma classifier."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.8139"}], "href": "https://doi.org/10.18632/oncotarget.8139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26993610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26993610"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Di Lu, Junxiong Wang, Xiaoyan Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AHNAK2 is a potential prognostic biomarker in patients with PDAC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15990"}], "href": "https://doi.org/10.18632/oncotarget.15990"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28423668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28423668"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Long Zheng, Shanshan Li, Xianghong Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AHNAK2 is a novel prognostic marker and correlates with immune infiltration in papillary thyroid cancer: Evidence from integrated analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2020.107185"}], "href": "https://doi.org/10.1016/j.intimp.2020.107185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33218938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33218938"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Dong-Wei Wang, Hai-Zheng Zheng, Na Cha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-Regulation of AHNAK2 Inhibits Cell Proliferation, Migration and Invasion Through Inactivating the MAPK Pathway in Lung Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033820957006"}], "href": "https://doi.org/10.1177/1533033820957006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33000678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33000678"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Miaosen Zheng, Jian Liu, Tingting Bian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correlation between prognostic indicator AHNAK2 and immune infiltrates in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2020.107134"}], "href": "https://doi.org/10.1016/j.intimp.2020.107134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33168407"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33168407"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Shusen Zhang, Yuanyuan Lu, Lei Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AHNAK2 Is Associated with Poor Prognosis and Cell Migration in Lung Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/8571932"}], "href": "https://doi.org/10.1155/2020/8571932"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32904605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32904605"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Mengyun Li, Yanchen Liu, Yanling Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AHNAK Nucleoprotein 2 Performs a Promoting Role in the Proliferation and Migration of Uveal Melanoma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biother Radiopharm (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/cbr.2019.2778"}], "href": "https://doi.org/10.1089/cbr.2019.2778"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31621397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31621397"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Runyi Ye, Dongwei Liu, Hongyu Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AHNAK2 promotes thyroid carcinoma progression by activating the NF-κB pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2021.120032"}], "href": "https://doi.org/10.1016/j.lfs.2021.120032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34627772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34627772"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Qiu-Yu Lin, Qian-Le Qi, Sen Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of AHNAK2 restricts thyroid carcinoma progression by inhibiting the Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2021_210304N276"}], "href": "https://doi.org/10.4149/neo_2021_210304N276"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34374294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34374294"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Aleksandr Kirov, Doreen Kacer, Barbara A Conley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AHNAK2 Participates in the Stress-Induced Nonclassical FGF1 Secretion Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.25047"}], "href": "https://doi.org/10.1002/jcb.25047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25560297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25560297"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shelisa Tey, Nortina Shahrizaila, Alexander P Drew, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linkage analysis and whole exome sequencing reveals AHNAK2 as a novel genetic cause for autosomal recessive CMT in a Malaysian family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurogenetics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10048-019-00576-3"}], "href": "https://doi.org/10.1007/s10048-019-00576-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31011849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31011849"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yang-Yang Zhou, Yan-Ting Kang, Chao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combination of TNM staging and pathway based risk score models in patients with gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.26563"}], "href": "https://doi.org/10.1002/jcb.26563"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29231991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29231991"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Hengwei Zhang, Lei Yang, Zhangyi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "iTRAQ-coupled 2D LC/MS-MS analysis of CXCR7-transfected papillary thyroid carcinoma cells: A new insight into CXCR7 regulation of papillary thyroid carcinoma progression and identification of potential biomarkers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2017.6574"}], "href": "https://doi.org/10.3892/ol.2017.6574"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28927140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28927140"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Motonobu Saito, Yutaka Fujiwara, Tetsuhiko Asao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The genomic and epigenomic landscape in thymic carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgx094"}], "href": "https://doi.org/10.1093/carcin/bgx094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28968686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28968686"}]}]}]}
Synonyms	C14ORF78
Proteins	AHNK2_HUMAN
NCBI Gene ID	113146
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

AHNAK2 has 12,040 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 116 datasets.

Click the + buttons to view associations for AHNAK2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

AHNAK2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AHNAK2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of AHNAK2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of AHNAK2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of AHNAK2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of AHNAK2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AHNAK2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of AHNAK2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AHNAK2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AHNAK2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of AHNAK2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of AHNAK2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of AHNAK2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with AHNAK2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with AHNAK2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AHNAK2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of AHNAK2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of AHNAK2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of AHNAK2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing AHNAK2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of AHNAK2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing AHNAK2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing AHNAK2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing AHNAK2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing AHNAK2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with AHNAK2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with AHNAK2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of AHNAK2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with AHNAK2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with AHNAK2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with AHNAK2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of AHNAK2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by AHNAK2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with AHNAK2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with AHNAK2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with AHNAK2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with AHNAK2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with AHNAK2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at AHNAK2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AHNAK2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of AHNAK2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.