{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n AKAIN1 (formerly known as C18orf42) encodes a short, neural tissue–enriched protein that interacts directly with the type II regulatory subunits of protein kinase A (PKA). Notably, rather than serving as a classical A-kinase anchoring protein (AKAP), AKAIN1 interferes with PKA’s typical subcellular localization mediated by AKAPs, thereby acting as an endogenous disruptor of PKA–AKAP interactions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, emerging genetic studies investigating rapid antidepressant responses to agents like ketamine and scopolamine have highlighted the potential utility of genome-wide markers to predict treatment outcomes in mood disorders. Although this study does not directly test AKAIN1, its role in modulating PKA signaling—a pathway implicated in neural plasticity and mood regulation—suggests that genetic variation in AKAIN1 might contribute to individual differences in rapid antidepressant response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Makiha Fukuda, Yasunori Aizawa "}, {"type": "b", "children": [{"type": "t", "text": "Hypothetical gene C18orf42 encodes a novel protein kinase A-binding protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/gtc.12217"}], "href": "https://doi.org/10.1111/gtc.12217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25653177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25653177"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Guo, Rodrigo Machado-Vieira, Sanjay Mathew, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-018-0311-7"}], "href": "https://doi.org/10.1038/s41398-018-0311-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30552317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30552317"}]}]}]}