{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a recent multi‐omic study investigating genetic factors underlying radiotoxicity in prostate cancer survivors, the gene ALG1L2 was identified as a genomic region of interest. Specifically, copy number variation analysis and transcriptomic profiling of whole‐blood samples showed that alterations in ALG1L2 were significantly associated with the development of proctitis following radiotherapy (4). This association suggests that ALG1L2 may play a role in modulating the cellular response to radiation‐induced damage. Based on pathway analyses that highlighted enriched functions such as DNA repair, mitochondrial apoptosis regulation, and cell‐to‐cell signaling processes, ALG1L2 might be involved—directly or indirectly—in processes that manage or mediate tissue responses to stress and inflammation after radiotherapy. Although the precise biological function of ALG1L2 remains to be fully elucidated, its identification in the context of radiotoxicity underscores its potential utility as a biomarker for predicting adverse effects from cancer treatment. Studies that integrate genomic and transcriptomic data offer promising avenues to further clarify the role of such candidate genes, complementing other investigations that have used whole exome or methylation analyses to uncover disease‐related genomic signatures (1,2,3)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ene Reimann, Sulev Kõks, Xuan Dung Ho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole exome sequencing of a single osteosarcoma case--integrative analysis with whole transcriptome RNA-seq data."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genomics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40246-014-0020-0"}], "href": "https://doi.org/10.1186/s40246-014-0020-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25496518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25496518"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wanding Zhou, Timothy J Triche, Peter W Laird, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gky691"}], "href": "https://doi.org/10.1093/nar/gky691"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30085201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30085201"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Masao Nagasaki, Yoko Kuroki, Tomoko F Shibata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of JRG (Japanese reference genome) with single-molecule real-time sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genome Var (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41439-019-0057-7"}], "href": "https://doi.org/10.1038/s41439-019-0057-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31231536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31231536"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Gita A Pathak, Renato Polimanti, Talisa K Silzer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetically-regulated transcriptomics & copy number variation of proctitis points to altered mitochondrial and DNA repair mechanisms in individuals of European ancestry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-020-07457-1"}], "href": "https://doi.org/10.1186/s12885-020-07457-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33008348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33008348"}]}]}]}