AMFR Gene

HGNC Family	Zinc fingers
Name	autocrine motility factor receptor, E3 ubiquitin protein ligase
Description	This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n AMFR (also known as gp78) is an endoplasmic reticulum–anchored E3 ubiquitin ligase that functions as a central regulator of protein quality control, lipid metabolism, innate immune signaling, apoptosis, and metastasis. In the context of ER‐associated degradation (ERAD), AMFR/gp78 cooperates with other E3s (e.g., RMA1) and the AAA ATPase p97/VCP to ubiquitinate misfolded proteins such as the ΔF508 variant of CFTR, thereby promoting their extraction from the ER and subsequent proteasomal degradation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, AMFR/gp78 plays a key role in regulating lipid homeostasis by binding to Insig-1 and mediating sterol-dependent ubiquitination events that control the degradation of critical enzymes and regulators such as HMG CoA reductase, Insig-1 itself, ACAT2, and apolipoprotein B."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, AMFR/gp78 is involved in modulating innate immune responses by catalyzing K27-linked polyubiquitination of STING, thereby facilitating the recruitment of downstream kinases and antiviral gene induction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n AMFR/gp78 further regulates cell fate decisions; for instance, it ubiquitinates the pro-apoptotic factor BOK, targeting it for proteasomal degradation and thus modulating mitochondrial outer membrane permeabilization and apoptosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", and it also promotes mitophagy by triggering ubiquitination of mitochondrial fusion regulators."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n The efficiency of AMFR-mediated ubiquitination is augmented by its selective binding to the E2 enzyme Ube2g2 via its G2BR domain, which not only enhances the affinity for the RING-finger region but also facilitates processive ubiquitin chain assembly."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In cancer, the prometastatic function of AMFR/gp78 is exemplified by its ability to associate with and target metastasis suppressor proteins such as KAI1 for degradation, thereby contributing to increased tumor invasiveness"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ", and it has been implicated in the degradation of proteins linked to neurodegenerative diseases, including SOD1 and ataxin-3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, AMFR/gp78 emerges as a multifaceted E3 ubiquitin ligase that integrates cellular quality control with metabolic and signaling pathways across diverse physiological and pathological contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "11"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "12"}, {"type": "fg_f", "ref": "14"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "16"}, {"type": "fg_f", "ref": "13"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "15"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "17"}, {"type": "fg_fs", "start_ref": "8", "end_ref": "10"}, {"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bao-Liang Song, Navdar Sever, Russell A DeBose-Boyd "}, {"type": "b", "children": [{"type": "t", "text": "Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2005.08.009"}], "href": "https://doi.org/10.1016/j.molcel.2005.08.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16168377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16168377"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daisuke Morito, Kazuyoshi Hirao, Yukako Oda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e07-06-0601"}], "href": "https://doi.org/10.1091/mbc.e07-06-0601"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18216283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18216283"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoyan Zhong, Yuxian Shen, Petek Ballar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M409034200"}], "href": "https://doi.org/10.1074/jbc.M409034200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15331598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15331598"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bo Chen, Jennifer Mariano, Yien Che Tsai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0506618103"}], "href": "https://doi.org/10.1073/pnas.0506618103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16407162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16407162"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Neeraj Vij, Shengyun Fang, Pamela L Zeitlin "}, {"type": "b", "children": [{"type": "t", "text": "Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M600509200"}], "href": "https://doi.org/10.1074/jbc.M600509200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16621797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16621797"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Guangtao Li, Gang Zhao, Xiaoke Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0602747103"}], "href": "https://doi.org/10.1073/pnas.0602747103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16709668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16709668"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Joon No Lee, Baoliang Song, Russell A DeBose-Boyd, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M608999200"}], "href": "https://doi.org/10.1074/jbc.M608999200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17043353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17043353"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tong-Fei Liu, Jing-Jie Tang, Pei-Shan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2012.06.014"}], "href": "https://doi.org/10.1016/j.cmet.2012.06.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22863805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22863805"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jun-Shan Liang, Tonia Kim, Shengyun Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M302683200"}], "href": "https://doi.org/10.1074/jbc.M302683200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12670940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12670940"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yong-Jian Wang, Yan Bian, Jie Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3551"}], "href": "https://doi.org/10.1038/ncb3551"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28604676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28604676"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Qiang Wang, Xing Liu, Ye Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2014.11.011"}], "href": "https://doi.org/10.1016/j.immuni.2014.11.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25526307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25526307"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Fabien Llambi, Yue-Ming Wang, Bernadette Victor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2016.02.026"}], "href": "https://doi.org/10.1016/j.cell.2016.02.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26949185"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26949185"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Min Fu, Pascal St-Pierre, Jay Shankar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of mitophagy by the Gp78 E3 ubiquitin ligase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E12-08-0607"}], "href": "https://doi.org/10.1091/mbc.E12-08-0607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23427266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23427266"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Wei Li, Daqi Tu, Axel T Brunger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature05542"}], "href": "https://doi.org/10.1038/nature05542"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17310145"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17310145"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ranabir Das, Jennifer Mariano, Yien Che Tsai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2009.05.010"}], "href": "https://doi.org/10.1016/j.molcel.2009.05.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19560420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19560420"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yien Che Tsai, Arnulfo Mendoza, Jennifer M Mariano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm1686"}], "href": "https://doi.org/10.1038/nm1686"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18037895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18037895"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Zheng Ying, Hongfeng Wang, Huadong Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddp380"}], "href": "https://doi.org/10.1093/hmg/ddp380"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19661182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19661182"}]}]}]}
Synonyms	RNF45, GP78
Proteins	AMFR_HUMAN
NCBI Gene ID	267
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

AMFR has 7,822 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 121 datasets.

Click the + buttons to view associations for AMFR from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

AMFR Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AMFR gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of AMFR gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of AMFR gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of AMFR gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of AMFR gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AMFR gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of AMFR gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AMFR gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AMFR gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of AMFR gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of AMFR gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of AMFR gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with AMFR protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AMFR gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of AMFR gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of AMFR gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with AMFR gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing AMFR protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of AMFR gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing AMFR protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing AMFR protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with AMFR protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with AMFR protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing AMFR protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of AMFR gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with AMFR gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with AMFR gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with AMFR gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of AMFR protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by AMFR gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving AMFR gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with AMFR gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with AMFR gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with AMFR gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with AMFR gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with AMFR gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at AMFR gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AMFR gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of AMFR gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing AMFR from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.