AMOT Gene

Name	angiomotin
Description	This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>Summary of AMOT Function</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Angiomotin (AMOT) proteins and their family members (AMOTL1 and AMOTL2) function as critical scaffold and adaptor molecules that integrate signals from cell–cell junctions, the actin cytoskeleton, and mechanical or metabolic cues to regulate Hippo pathway activity. Through direct interactions with the transcriptional co‐activators YAP and TAZ via conserved PPxY motifs, AMOT proteins sequester these effectors at tight or adherens junctions, thereby limiting their nuclear translocation and transcriptional activity. This regulation is central to maintaining contact inhibition, cell polarity, and proper control of proliferation, as the cytoplasmic retention imposed by AMOT prevents aberrant gene expression associated with oncogenic transformation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In some contexts, particularly through the p130 isoform that harbors an F‐actin–binding extension, AMOT can also modulate cell shape and actin organization. Such isoform-specific properties allow AMOT to differentially influence cellular migration and junction stability, and even support nuclear YAP activity by blocking phosphorylation by LATS kinases, thus acting as a cofactor in the transcriptional regulation of genes associated with tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, AMOT proteins participate in the spatial control of Hippo signaling in developing embryos and endothelial cells. In preimplantation embryos, for example, the junctional localization of AMOT in inner cells promotes Hippo pathway activation, thereby contributing to cell fate determination; in endothelial cells, AMOT and the related AMOTL1 regulate both directional migration and the integrity of cell–cell junctions, essential for proper vascular patterning."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, post-translational modifications—such as AMPK-mediated phosphorylation—modulate AMOT stability and its ability to restrain YAP/TAZ activity in response to energy stress. Collectively, these findings underscore the dual nature of AMOT proteins as both inhibitors and facilitators of YAP/TAZ signaling depending on the cellular context, thereby linking junctional integrity, actin dynamics, and mechanical or metabolic status to the control of cell proliferation, polarity, migration, and oncogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bin Zhao, Li Li, Qing Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.2000111"}], "href": "https://doi.org/10.1101/gad.2000111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21205866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21205866"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Siew Wee Chan, Chun Jye Lim, Yaan Fun Chong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hippo pathway-independent restriction of TAZ and YAP by angiomotin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C110.212621"}], "href": "https://doi.org/10.1074/jbc.C110.212621"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21224387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21224387"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yoshikazu Hirate, Shino Hirahara, Ken-Ichi Inoue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2013.05.014"}], "href": "https://doi.org/10.1016/j.cub.2013.05.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23791731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23791731"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Michael DeRan, Jiayi Yang, Che-Hung Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2014.09.036"}], "href": "https://doi.org/10.1016/j.celrep.2014.09.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25373897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25373897"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chunling Yi, Zhewei Shen, Anat Stemmer-Rachamimov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2004060"}], "href": "https://doi.org/10.1126/scisignal.2004060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24003254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24003254"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mira Ernkvist, Karin Aase, Chinwe Ukomadu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p130-angiomotin associates to actin and controls endothelial cell shape."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2006.05216.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2006.05216.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16640563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16640563"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yujuan Zheng, Simona Vertuani, Staffan Nyström, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.109.195156"}], "href": "https://doi.org/10.1161/CIRCRESAHA.109.195156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19590046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19590046"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "T Oka, A P Schmitt, M Sudol "}, {"type": "b", "children": [{"type": "t", "text": "Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.216"}], "href": "https://doi.org/10.1038/onc.2011.216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21685940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21685940"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Susana Moleirinho, William Guerrant, Joseph L Kissil "}, {"type": "b", "children": [{"type": "t", "text": "The Angiomotins--from discovery to function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2014.02.006"}], "href": "https://doi.org/10.1016/j.febslet.2014.02.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24548561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24548561"}]}]}]}
Proteins	AMOT_HUMAN
NCBI Gene ID	154796
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

AMOT has 6,255 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 116 datasets.

Click the + buttons to view associations for AMOT from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

AMOT Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AMOT gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of AMOT gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of AMOT gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of AMOT gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AMOT gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of AMOT gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AMOT gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AMOT gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of AMOT gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of AMOT gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of AMOT gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with AMOT protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with AMOT gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AMOT gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of AMOT gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of AMOT gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing AMOT protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of AMOT gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing AMOT protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing AMOT protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with AMOT protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with AMOT protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing AMOT protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of AMOT gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with AMOT gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with AMOT gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with AMOT gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of AMOT protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by AMOT gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with AMOT gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with AMOT gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with AMOT gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with AMOT gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at AMOT gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AMOT gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of AMOT gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing AMOT from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with AMOT gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of AMOT gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with AMOT gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.