ANAPC13 Gene

HGNC Family	Anaphase promoting complex subunits (ANAPC)
Name	anaphase promoting complex subunit 13
Description	This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ANAPC13 is emerging as an important multifunctional protein that plays roles in cell cycle regulation as a component of the anaphase‐promoting complex/cyclosome (APC/C). Structural studies of APC/C assembly have identified ANAPC13 as one of the small subunits that likely contributes to proper substrate recruitment and ubiquitination—a key process ensuring orderly mitotic progression and genomic stability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, oncologic studies have demonstrated that perturbations in ANAPC13 expression may promote malignant progression. For instance, its down‐regulation has been observed as an early event in breast ductal carcinoma progression, with further decreases being associated with higher genomic instability and poorer survival outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In liver cancer, a frequently occurring non‐coding somatic mutation that disrupts enhancer activity has been shown to affect the promoter region of ANAPC13, implicating aberrant regulation of this gene in tumorigenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while network‐based studies in oral cancer have identified ANAPC13 among several differentially expressed genes, suggesting its potential as a novel drug target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in cancer, ANAPC13 has been linked to developmental and tissue‐specific functions. In studies of goat oocyte maturation, for example, altered expression of ANAPC13 was detected among key regulatory genes, indicating a potential function in the maturation process of oocytes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Furthermore, integrative gene expression profiling in a diabetic macrovasculopathy model identified ANAPC13 as one of several candidate target genes through which a traditional herbal formula exerted protective effects on skeletal muscle tissue."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Polymorphism analyses have also associated genetic variants in non‐coding regions of ANAPC13 with differences in body measurement traits, suggesting its involvement in growth regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore the multifaceted role of ANAPC13 across diverse biological contexts—from its foundational function in cell cycle control and maintenance of genomic integrity to its emerging involvement in oncogenesis, developmental regulation, and tissue homeostasis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Masaya Yamaguchi, Shanshan Yu, Renping Qiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2014.11.020"}], "href": "https://doi.org/10.1016/j.jmb.2014.11.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25490258"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25490258"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Carolina Sens-Abuázar, Elisa Napolitano E Ferreira, Cynthia Aparecida Bueno Toledo Osório, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of ANAPC13 and CLTCL1: Early Events in the Progression of Preinvasive Ductal Carcinoma of the Breast."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/tlo.11280"}], "href": "https://doi.org/10.1593/tlo.11280"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22496928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22496928"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "M Cavalli, K Diamanti, G Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A non-coding cancer mutation disrupting an HNF4α binding motif affects an enhancer regulating genes associated to the progression of liver cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.32471/exp-oncology.2312-8852.vol-43-no-1.15925"}], "href": "https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-1.15925"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33785712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33785712"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Syeda Zahra Abbas, Muhammad Imran Qadir, Syed Aun Muhammad "}, {"type": "b", "children": [{"type": "t", "text": "Systems-level differential gene expression analysis reveals new genetic variants of oral cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-71346-7"}], "href": "https://doi.org/10.1038/s41598-020-71346-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32887903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32887903"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "X Y Yin, G H Cheng, H Y Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single cell transcriptome profiling revealed differences in gene expression during oocyte maturation in Haimen white goats."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/gmr16019564"}], "href": "https://doi.org/10.4238/gmr16019564"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28301674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28301674"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yuhong Duan, Hong Gao, Hongxia Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exploring the Protective Effect of ShenQi Compound on Skeletal Muscle in Diabetic Macrovasculopathy Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Metab Immune Disord Drug Targets (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1871530320666200225094756"}], "href": "https://doi.org/10.2174/1871530320666200225094756"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32096754"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32096754"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "B J Jiang, X L Zhan, C Z Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of ANAPC13 gene polymorphisms associated with body measurement traits in Bos taurus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/2012.June.15.6"}], "href": "https://doi.org/10.4238/2012.June.15.6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22782628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22782628"}]}]}]}
Synonyms	APC13, SWM1
Proteins	APC13_HUMAN
NCBI Gene ID	25847
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ANAPC13 has 5,077 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 104 datasets.

Click the + buttons to view associations for ANAPC13 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ANAPC13 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ANAPC13 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ANAPC13 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ANAPC13 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ANAPC13 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ANAPC13 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ANAPC13 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ANAPC13 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ANAPC13 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ANAPC13 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ANAPC13 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ANAPC13 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ANAPC13 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ANAPC13 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ANAPC13 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ANAPC13 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ANAPC13 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ANAPC13 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ANAPC13 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ANAPC13 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ANAPC13 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ANAPC13 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ANAPC13 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ANAPC13 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ANAPC13 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with ANAPC13 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ANAPC13 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ANAPC13 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ANAPC13 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ANAPC13 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ANAPC13 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ANAPC13 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ANAPC13 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ANAPC13 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ANAPC13 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ANAPC13 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ANAPC13 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ANAPC13 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of ANAPC13 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of ANAPC13 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of ANAPC13 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.