ANKRD63 Gene

HGNC Family Ankyrin repeat domain containing (ANKRD)
Name ankyrin repeat domain 63
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Two recent studies have provided insights into the potential roles of the ankyrin repeat domain 63 (ANKRD63) gene in distinct biological contexts. In one study examining epigenetic responses to psychosocial stress among Sub-Saharan African migrants in Europe, ANKRD63 was identified as one of two genes exhibiting significant hypomethylation associated with increased perceived discrimination. This epigenetic alteration suggests that ANKRD63 may be involved in the molecular response to psychosocial stress, although its precise functional contribution remains to be elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a complementary investigation employing high-resolution, mass spectrometry–based proteomics across 19 human brain regions, ANKRD63 emerged as a region-specific marker in the basal ganglia. This finding links the gene to neuroanatomical specificity and may have implications for understanding the molecular underpinnings of brain function and associated neurological disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies highlight the potential dual role of ANKRD63 in mediating stress-related epigenetic modifications in peripheral blood cells and in contributing to the regional protein landscape of the human brain. Further research is needed to clarify the mechanistic pathways through which ANKRD63 may influence both psychosocial stress responses and basal ganglia function.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Loes C van der Laan, Karlijn A C Meeks, Felix P Chilunga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenome-wide association study for perceived discrimination among sub-Saharan African migrants in Europe - the RODAM study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-61649-0"}], "href": "https://doi.org/10.1038/s41598-020-61649-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32188935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32188935"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Deeptarup Biswas, Sanjyot Vinayak Shenoy, Chetanya Chetanya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deciphering the Interregional and Interhemisphere Proteome of the Human Brain in the Context of the Human Proteome Project."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jproteome.1c00511"}], "href": "https://doi.org/10.1021/acs.jproteome.1c00511"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34714085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34714085"}]}]}]}
Proteins ANR63_HUMAN
NCBI Gene ID 100131244
API
Download Associations
Predicted Functions View ANKRD63's ARCHS4 Predicted Functions.
Co-expressed Genes View ANKRD63's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View ANKRD63's ARCHS4 Predicted Functions.

Functional Associations

ANKRD63 has 2,274 functional associations with biological entities spanning 8 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 36 datasets.

Click the + buttons to view associations for ANKRD63 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of ANKRD63 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of ANKRD63 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of ANKRD63 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of ANKRD63 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of ANKRD63 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of ANKRD63 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of ANKRD63 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with ANKRD63 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with ANKRD63 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with ANKRD63 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at ANKRD63 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of ANKRD63 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of ANKRD63 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing ANKRD63 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of ANKRD63 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of ANKRD63 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of ANKRD63 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GTEx eQTL 2025 SNPs regulating expression of ANKRD63 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of ANKRD63 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of ANKRD63 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with ANKRD63 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with ANKRD63 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for ANKRD63 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of ANKRD63 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of ANKRD63 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of ANKRD63 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of ANKRD63 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of ANKRD63 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of ANKRD63 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2024 pathways involving ANKRD63 protein from the Wikipathways PFOCR 2024 dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of ANKRD63 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at ANKRD63 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of ANKRD63 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of ANKRD63 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of ANKRD63 gene from the RummaGEO Gene Perturbation Signatures dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with ANKRD63 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.