ANKS1A Gene

HGNC Family	Sterile alpha motif (SAM) domain containing (SAMD), Ankyrin repeat domain containing (ANKRD)
Name	ankyrin repeat and sterile alpha motif domain containing 1A
Description	Predicted to enable ephrin receptor binding activity. Predicted to be involved in ephrin receptor signaling pathway; neuron remodeling; and substrate-dependent cell migration. Predicted to act upstream of or within negative regulation of ubiquitin-dependent protein catabolic process and regulation of ephrin receptor signaling pathway. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The ANKS1A gene – whose product is also known as Odin – encodes a multifunctional adaptor protein that plays a critical role in several signaling and trafficking pathways. Studies have shown that Odin functions as an effector in receptor trafficking by regulating endocytic processing. For example, Odin becomes tyrosine‐phosphorylated early following epidermal growth factor (EGF) stimulation and promotes the recycling of EGFR from endosomes back to the cell surface while limiting its lysosomal degradation (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In accord with its modular structure, which includes sterile α‐motif (SAM) and phosphotyrosine binding (PTB) domains, Odin interacts with other SAM‐containing proteins – such as Arap3 – and participates in heterotypic complex formation that may contribute to the modulation of receptor signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its role in receptor trafficking, ANKS1A is important for cellular differentiation. Odin is prominently expressed in the ependymal cells lining the brain ventricles, where it is required for the normal maturation and differentiation of these cells. Loss of ANKS1A function, or expression of a dominant-negative variant lacking the PTB domain, disrupts ependymal cell development and results in aberrant cell characteristics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, genetic studies indicate that variants in ANKS1A can influence disease phenotypes. A specific polymorphism within the ANKS1A locus has been linked to a reduced risk of major adverse cardiovascular events in familial hypercholesterolemia, and other studies have implicated ANKS1A single nucleotide polymorphisms in the modulation of serologic profiles in systemic lupus erythematosus."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In the context of cancer, ANKS1A has been shown to interact with key tyrosine kinase receptors such as EphA2; through its ability to bind both EphA2 and components of the protein secretion machinery (Sec23/COPII vesicles), Odin facilitates the selective packaging and cell surface expression of these receptors. This mechanism has been linked to the stabilization of ErbB2 and enhanced breast tumorigenesis, as ANKS1A deficiency in animal models substantially reduces tumor development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, ANKS1A (Odin) serves as a versatile adaptor that integrates receptor tyrosine kinase signaling with intracellular trafficking and cell differentiation processes. Its ability to assemble multi‐protein complexes via its modular domains is central to regulating receptor recycling, modulating immune and inflammatory responses, and influencing pathological processes such as cancer and cardiovascular disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": " \n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jiefei Tong, Yaroslav Sydorskyy, Jonathan R St-Germain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Odin (ANKS1A) modulates EGF receptor recycling and stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0064817"}], "href": "https://doi.org/10.1371/journal.pone.0064817"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23825523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23825523"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Flavia A Mercurio, Daniela Marasco, Luciano Pirone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterotypic Sam-Sam association between Odin-Sam1 and Arap3-Sam: binding affinity and structural insights."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chembiochem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbic.201200592"}], "href": "https://doi.org/10.1002/cbic.201200592"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23239578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23239578"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sunjung Park, Haeryung Lee, Jiyeon Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ependymal Cells Require Anks1a for Their Proper Development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14348/molcells.2018.0432"}], "href": "https://doi.org/10.14348/molcells.2018.0432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30759972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30759972"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sunjung Park, Haeryung Lee, Soochul Park "}, {"type": "b", "children": [{"type": "t", "text": "In Vivo Expression of the PTB-deleted Odin Mutant Results in Hydrocephalus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14348/molcells.2015.2288"}], "href": "https://doi.org/10.14348/molcells.2015.2288"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26018557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26018557"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Silvia N Kariuki, Beverly S Franek, Akaash A Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Res Ther (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/ar3101"}], "href": "https://doi.org/10.1186/ar3101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20659327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20659327"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Martin L Tomov, Zachary T Olmsted, Haluk Dogan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct and Shared Determinants of Cardiomyocyte Contractility in Multi-Lineage Competent Ethnically Diverse Human iPSCs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep37637"}], "href": "https://doi.org/10.1038/srep37637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27917881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27917881"}]}]}]}
Synonyms	ANKS1
Proteins	ANS1A_HUMAN
NCBI Gene ID	23294
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ANKS1A has 6,371 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 127 datasets.

Click the + buttons to view associations for ANKS1A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ANKS1A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ANKS1A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ANKS1A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ANKS1A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ANKS1A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ANKS1A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ANKS1A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ANKS1A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ANKS1A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ANKS1A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ANKS1A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ANKS1A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ANKS1A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ANKS1A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ANKS1A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ANKS1A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ANKS1A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ANKS1A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ANKS1A protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ANKS1A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ANKS1A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ANKS1A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ANKS1A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ANKS1A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ANKS1A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ANKS1A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ANKS1A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with ANKS1A gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ANKS1A gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ANKS1A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ANKS1A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ANKS1A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ANKS1A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ANKS1A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ANKS1A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ANKS1A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ANKS1A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ANKS1A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ANKS1A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ANKS1A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ANKS1A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.