ANXA6 Gene

HGNC Family	Annexins (ANXA)
Name	annexin A6
Description	Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Annexin A6 (ANXA6) is a multifunctional, Ca2⁺‐dependent membrane-binding protein that regulates diverse cellular processes through its roles in membrane repair, vesicular trafficking, and signal transduction. At the plasma membrane, ANXA6 functions as a scaffold that organizes the assembly of signaling complexes and modulates receptor endocytosis and cholesterol distribution, thereby influencing caveolin trafficking and downstream pathways such as those mediated by Ras and protein kinase C (3,4,5). In addition, ANXA6 contributes to cell–cell and cell–extracellular matrix adhesion, with its expression levels affecting breast cancer cell adhesion, migration, and invasiveness (5,6). In the context of tumor–stroma interactions, ANXA6 is incorporated into extracellular vesicles released by cancer‐associated fibroblasts, and these vesicles promote tumor cell survival and aggressiveness, underscoring its role in intercellular communication in pancreatic ductal adenocarcinoma (1). Moreover, ANXA6 is essential for efficient plasma membrane repair; genetic studies in muscle have identified ANXA6 as a critical modifier that orchestrates the formation of membrane repair “caps” at injury sites, while aberrant, truncated ANXA6 impairs repair and exacerbates muscle pathology (2). Recently, ANXA6 has also been implicated in the regulation of mitochondrial morphology and function; by interacting with the fission mediator Drp1, ANXA6 restrains mitochondrial fragmentation, thereby ensuring proper respiratory function and Ca2⁺ homeostasis (7). Collectively, these findings establish ANXA6 as a key regulator of membrane integrity, vesicle-mediated communication, and intracellular signaling, with implications for cancer progression, muscle repair, and mitochondrial dynamics.\n "}]}, {"type": "t", "text": "\n <ul>\n <li>."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Abstract 27701147</li>\n <li>."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Abstract 24717843</li>\n <li>."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "Abstract 17822395</li>\n <li>."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "Abstract 20888375</li>\n <li>."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "Abstract 22797061</li>\n <li>."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "Abstract 21185831</li>\n <li>."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "Abstract 23341998</li>\n </ul>"}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Julie Leca, Sébastien Martinez, Sophie Lac, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI87734"}], "href": "https://doi.org/10.1172/JCI87734"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27701147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27701147"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kayleigh A Swaggart, Alexis R Demonbreun, Andy H Vo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Annexin A6 modifies muscular dystrophy by mediating sarcolemmal repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1324242111"}], "href": "https://doi.org/10.1073/pnas.1324242111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24717843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24717843"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Laia Cubells, Sandra Vilà de Muga, Francesc Tebar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Annexin A6-induced alterations in cholesterol transport and caveolin export from the Golgi complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2007.00640.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2007.00640.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17822395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17822395"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Carlos Enrich, Carles Rentero, Sandra Vilà de Muga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Annexin A6-Linking Ca(2+) signaling with cholesterol transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2010.09.015"}], "href": "https://doi.org/10.1016/j.bbamcr.2010.09.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20888375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20888375"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "M Koese, C Rentero, B P Kota, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Annexin A6 is a scaffold for PKCα to promote EGFR inactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.303"}], "href": "https://doi.org/10.1038/onc.2012.303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22797061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22797061"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Amos M Sakwe, Rainelli Koumangoye, Bobby Guillory, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Annexin A6 contributes to the invasiveness of breast carcinoma cells by influencing the organization and localization of functional focal adhesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2010.12.008"}], "href": "https://doi.org/10.1016/j.yexcr.2010.12.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21185831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21185831"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Marcin Chlystun, Michelangelo Campanella, Ah-Lai Law, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of mitochondrial morphogenesis by annexin A6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0053774"}], "href": "https://doi.org/10.1371/journal.pone.0053774"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23341998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23341998"}]}]}]}
Synonyms	CBP68, ANX6, p68, CPB-II
Proteins	ANXA6_HUMAN
NCBI Gene ID	309
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ANXA6 has 10,501 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 121 datasets.

Click the + buttons to view associations for ANXA6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ANXA6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ANXA6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ANXA6 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ANXA6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ANXA6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ANXA6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ANXA6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ANXA6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ANXA6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ANXA6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ANXA6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ANXA6 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ANXA6 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ANXA6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ANXA6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ANXA6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ANXA6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ANXA6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ANXA6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ANXA6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ANXA6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing ANXA6 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ANXA6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ANXA6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ANXA6 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ANXA6 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ANXA6 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ANXA6 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ANXA6 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ANXA6 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ANXA6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ANXA6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ANXA6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ANXA6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ANXA6 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ANXA6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ANXA6 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ANXA6 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ANXA6 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ANXA6 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ANXA6 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.