{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that long non‐coding RNA AOC4P plays a significant tumor‐suppressive role in several cancers. In hepatocellular carcinoma, AOC4P is notably downregulated and correlates with advanced clinical stage and invasive features. Functional assays demonstrated that its restoration suppresses cell proliferation, migration, and invasion by binding to vimentin, thereby promoting its degradation and inhibiting the epithelial–mesenchymal transition (EMT)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in non‐small cell lung cancer, overexpression of AOC4P inhibited cell viability and invasion while inducing apoptosis via suppression of the Wnt/β‐catenin pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In breast cancer, decreased AOC4P levels were significantly associated with worse clinical outcomes, suggesting that its dysregulation may contribute to tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n \n \nIn addition to its role in these malignancies, investigations have extended to other tumor types. Studies in epithelial ovarian cancer have begun to elucidate the potential involvement of AOC4P in the EMT process"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while research focusing on gastric cancer is assessing its expression and functional relevance in disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n\n \nBeyond tumor biology, aberrant regulation of AOC4P has also been implicated in pregnancy complications. In cases of recurrent spontaneous abortion, AOC4P is upregulated in villous tissues where it impairs trophoblast glycolysis and hinders the polarization of M2 macrophages. Mechanistically, AOC4P interacts with TRAF6 to elevate its expression, which in turn promotes the ubiquitination and degradation of EZH2, thereby disturbing the anti‐inflammatory milieu essential for successful embryo implantation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tong-Hong Wang, Yong-Shiang Lin, Ying Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA AOC4P suppresses hepatocellular carcinoma metastasis by enhancing vimentin degradation and inhibiting epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4344"}], "href": "https://doi.org/10.18632/oncotarget.4344"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26160837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26160837"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fengbo Li, Tao Rong, Gang Cao, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LncRNA AOC4P affects biological behavior of gastric cancer cells through MAPK signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201910_19280"}], "href": "https://doi.org/10.26355/eurrev_201910_19280"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31696472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31696472"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shujuan Wu, Lu Han, Mengqi Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA AOC4P recruits TRAF6 to regulate EZH2 ubiquitination and participates in trophoblast glycolysis and M2 macrophage polarization which is associated with recurrent spontaneous abortion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2023.111201"}], "href": "https://doi.org/10.1016/j.intimp.2023.111201"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37951195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37951195"}]}]}]}