{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong non‐coding RNA APOC1P1 has emerged as a critical regulatory molecule in cancer. In breast cancer, the APOC1P1-3 transcript is markedly overexpressed, a phenomenon that is associated with larger tumor size and hypomethylation of its promoter region. Mechanistically, APOC1P1-3 directly binds to tubulin, leading to decreased α-tubulin acetylation, subsequent inactivation of caspase-3, and ultimately inhibition of apoptosis. This anti‐apoptotic function suggests that APOC1P1-3 contributes to tumor cell survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Renal cell carcinoma studies further implicate APOC1P1 as an oncogenic factor. In clear cell renal cell carcinoma (ccRCC), APOC1P1 expression is significantly elevated compared to normal kidney tissues, with even higher levels observed in advanced tumor grades and stages. Functional experiments demonstrate that knockdown of APOC1P1 suppresses cell proliferation, impedes migration and invasion, promotes apoptosis, and induces G1/S cell cycle arrest, collectively underscoring its role in driving tumor progression and its potential as a prognostic biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "In addition to its functional roles in tumorigenesis, APOC1P1 also exhibits strong diagnostic promise. Analysis of breast tumor samples reveals that APOC1P1, together with other long non-coding RNAs such as AK058003, is significantly overexpressed in tumor tissues relative to adjacent non-tumor tissues, further supporting its potential utility as a biomarker for early cancer detection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "X-H Liao, J-G Wang, L-Y Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-coding RNA APOC1P1-3 inhibits apoptosis by decreasing α-tubulin acetylation in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2016.142"}], "href": "https://doi.org/10.1038/cddis.2016.142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27228351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27228351"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chong Sun, Zhonghan Zhou, Haoqing Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Long Noncoding RNA APOC1P1 as an Oncogene in Clear Cell Renal Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2019/2814058"}], "href": "https://doi.org/10.1155/2019/2814058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31871500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31871500"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ali Rajabi, Ali Saber, Sepehr Abdolahi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of lncRNAs AK058003 and APOC1P1 in breast cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleosides Nucleotides Nucleic Acids (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15257770.2022.2075556"}], "href": "https://doi.org/10.1080/15257770.2022.2075556"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35580209"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35580209"}]}]}]}