{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Aquaporin‐7 (AQP7) is an aquaglyceroporin that plays a central role in whole‐body energy homeostasis by facilitating the bidirectional movement of glycerol across cell membranes. In adipocytes, AQP7 functions as a “glycerol gateway,” allowing efficient efflux of glycerol derived from triglyceride hydrolysis into the circulation, where it can serve as a substrate for hepatic gluconeogenesis and triglyceride synthesis. Studies in AQP7‐deficient mice have demonstrated that disruption of AQP7 leads to reduced plasma glycerol levels, intracellular glycerol accumulation, enhanced glycerol kinase activity, adipocyte hypertrophy, increased fat mass, and ultimately adult‐onset obesity and insulin resistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In human adipose tissue, lower AQP7 expression has been associated with obesity and related metabolic disturbances, underscoring its importance in maintaining normal glycerol homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, AQP7 is not restricted solely to adipocytes; it is also localized to the capillary endothelium of adipose tissue and expressed in other tissues, including the heart, where it contributes to glycerol uptake and energy substrate provision in cardiomyocytes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In addition, research in yeast and mammalian cell models has suggested a role for AQP7 in mediating the uptake of metalloids such as arsenite, indicating that its substrate specificity may extend beyond glycerol and water in certain contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, these findings emphasize that AQP7 is a key regulator of glycerol flux, with its activity influencing lipid storage, glucose metabolism, and overall energy balance—highlighting its potential as a target for intervention in obesity and metabolic disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Toshiyuki Hibuse, Norikazu Maeda, Tohru Funahashi, et al. 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